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serotype 1
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serotype 3
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SPN994038
serotype 3
SPN994039
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serotype 3
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TCH8431/19A
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Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 670-6B
  • locus tag: SP670_1860 [new locus tag: SP670_RS09245 ]
  • pan locus tag?: PNEUPAN003243000
  • symbol: prmA
  • pan gene symbol?: prmA
  • synonym:
  • product: ribosomal protein L11 methyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP670_1860 [new locus tag: SP670_RS09245 ]
  • symbol: prmA
  • product: ribosomal protein L11 methyltransferase
  • replicon: chromosome
  • strand: -
  • coordinates: 1734060..1735010
  • length: 951
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGGAAACATGGCAAGAGTTAAAAGTTACAGTGAAGCGTGAGGGAGAGGAGTTGGTTTCC
    AATCTCTTGATTGAGTTAGGTGCCCAAGGGGTAGCAATTGAAGACAGCATGGACTATGTG
    GGAAATGTGGACCGATTCGGTGAAATTTTCCCAGAGGTGGAGCAACAGGAAGAAATCGTA
    GTGACCGCCTACTACCCTGAAACGGTTGATGTAGCAGCAGTTGAAGCGGATTTGCAGGCT
    CGTCTGGCAGAATTGACCGACTTTATGGACCTAGGAGAAGTCAAGATGGGCACGACTGCC
    TTGACTGAGGAAGACTGGGCTGACAACTGGAAGAAGTATTATGAACCGGCACGCATCACC
    CATGACCTGACCATCGTACCGTCATGGACGGACTATGAGGCAACAGCAGGAGAAAAGATT
    ATCAAGCTGGATCCTGGTATGGCCTTTGGGACAGGGACCCACCCAACAACCAAGATGAGC
    CTCTTTGCCTTGGAACAGGTTCTTCGTGGTGGCGAAACAGTGCTAGATGTAGGGACTGGT
    TCAGGGGTTCTTTCTATTGCAAGCTCACTCCTAGGTGCCAAGGAGATTTTCGCCTATGAC
    TTGGATGATGTGGCGGTTCGTGTCGCTCAGGAAAATATTGAGCTCAACACTGGTATGGAA
    AATATCCATGTAGCAGCAGGAGATTTGCTTAAGGGTGTGGAAATTGAGGCAGATGTGATT
    GTGGCTAATATCTTGGCGGATATCCTCATTCATCTAATAGACGATGCCTATCGTTTGGTC
    AAGGATGAAGGCTACCTCATCATGAGTGGCATTATCAAGGACAAGTGGGACATGGTGCGC
    CAGTCGGCTGAGTCAGCTGGATTTTTCCTCGAAACTCACATGGTTCAAGGGGAATGGAAT
    ACCTGTGTCTTTAAGAAAACCAAGGATATCTCTGGTGTGATTGGAGGCTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    951

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP670_1860 [new locus tag: SP670_RS09245 ]
  • symbol: PrmA
  • description: ribosomal protein L11 methyltransferase
  • length: 316
  • theoretical pI: 4.02173
  • theoretical MW: 34774.1
  • GRAVY: -0.00822785

⊟Function[edit | edit source]

  • reaction:
    EC 2.1.1.-?  ExPASy
  • TIGRFAM:
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification ribosomal protein L11 methyltransferase (TIGR00406; EC 2.1.1.-; HMM-score: 239.7)
    and 20 more
    Genetic information processing Protein fate Protein modification and repair protein-(glutamine-N5) methyltransferase, release factor-specific (TIGR03534; EC 2.1.1.-; HMM-score: 42.7)
    Genetic information processing Protein fate Protein modification and repair methyltransferase, HemK family (TIGR00536; HMM-score: 38.2)
    Unknown function Enzymes of unknown specificity putative methylase (TIGR00537; HMM-score: 38.1)
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific (TIGR03533; EC 2.1.1.-; HMM-score: 33.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll magnesium protoporphyrin O-methyltransferase (TIGR02021; EC 2.1.1.11; HMM-score: 29.4)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 3-demethylubiquinone-9 3-O-methyltransferase (TIGR01983; EC 2.1.1.64; HMM-score: 27.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit (TIGR02469; EC 2.1.1.132; HMM-score: 27.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin malonyl-acyl carrier protein O-methyltransferase BioC (TIGR02072; EC 2.1.1.-; HMM-score: 26.5)
    methyltransferase, ATP-grasp peptide maturase system (TIGR04188; HMM-score: 25.6)
    Genetic information processing Protein synthesis Ribosomal proteins: synthesis and modification putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific (TIGR03704; EC 2.1.1.-; HMM-score: 22)
    Genetic information processing Protein synthesis tRNA and rRNA base modification 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG (TIGR00138; EC 2.1.1.170; HMM-score: 15.4)
    Genetic information processing Protein fate Protein modification and repair protein-L-isoaspartate O-methyltransferase (TIGR00080; EC 2.1.1.77; HMM-score: 15.1)
    Hypothetical proteins Conserved putative methyltransferase, TIGR01177 family (TIGR01177; HMM-score: 14.9)
    methyltransferase, FkbM family (TIGR01444; HMM-score: 13.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone ubiquinone/menaquinone biosynthesis methyltransferase (TIGR01934; EC 2.1.1.-; HMM-score: 13.4)
    Genetic information processing Protein synthesis tRNA and rRNA base modification ribosomal RNA small subunit methyltransferase A (TIGR00755; EC 2.1.1.182; HMM-score: 13.3)
    methyltransferase, Rta_06860 family (TIGR04290; EC 2.1.1.-; HMM-score: 13.2)
    Genetic information processing Protein synthesis tRNA and rRNA base modification 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD (TIGR00095; EC 2.1.1.171; HMM-score: 13.1)
    Metabolism Amino acid biosynthesis Aspartate family methionine biosynthesis protein MetW (TIGR02081; HMM-score: 11.6)
    Genetic information processing Protein synthesis tRNA and rRNA base modification N2,N2-dimethylguanosine tRNA methyltransferase (TIGR00308; EC 2.1.1.-; HMM-score: 11.4)
  • TheSEED  :
    • Ribosomal protein L11 methyltransferase (EC 2.1.1.-)
    Protein Metabolism Protein biosynthesis Ribosome biogenesis bacterial  Ribosomal protein L11 methyltransferase (EC 2.1.1.-)
    and 1 more
    Stress Response Heat shock Heat shock dnaK gene cluster extended  Ribosomal protein L11 methyltransferase (EC 2.1.1.-)
  • PFAM:
    NADP_Rossmann (CL0063) PrmA; Ribosomal protein L11 methyltransferase (PrmA) (PF06325; HMM-score: 366.4)
    and 15 more
    MTS; Methyltransferase small domain (PF05175; HMM-score: 42)
    Methyltransf_31; Methyltransferase domain (PF13847; HMM-score: 34)
    Met_10; Met-10+ like-protein (PF02475; HMM-score: 29.8)
    Methyltransf_25; Methyltransferase domain (PF13649; HMM-score: 27.4)
    Methyltransf_18; Methyltransferase domain (PF12847; HMM-score: 26.4)
    Methyltransf_23; Methyltransferase domain (PF13489; HMM-score: 22.5)
    Methyltransf_11; Methyltransferase domain (PF08241; HMM-score: 21.9)
    PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) (PF01135; HMM-score: 20.6)
    Methyltransf_16; Lysine methyltransferase (PF10294; HMM-score: 19.2)
    Cons_hypoth95; Conserved hypothetical protein 95 (PF03602; HMM-score: 17.9)
    GCD14; tRNA methyltransferase complex GCD14 subunit (PF08704; HMM-score: 15.5)
    Methyltransf_12; Methyltransferase domain (PF08242; HMM-score: 15.2)
    TRM; N2,N2-dimethylguanosine tRNA methyltransferase (PF02005; HMM-score: 14)
    NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family (PF01234; HMM-score: 12.9)
    CMAS; Mycolic acid cyclopropane synthetase (PF02353; HMM-score: 10.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004006
    • TAT(Tat/SPI): 0.000649
    • LIPO(Sec/SPII): 0.000514
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADM91912 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • METWQELKVTVKREGEELVSNLLIELGAQGVAIEDSMDYVGNVDRFGEIFPEVEQQEEIVVTAYYPETVDVAAVEADLQARLAELTDFMDLGEVKMGTTALTEEDWADNWKKYYEPARITHDLTIVPSWTDYEATAGEKIIKLDPGMAFGTGTHPTTKMSLFALEQVLRGGETVLDVGTGSGVLSIASSLLGAKEIFAYDLDDVAVRVAQENIELNTGMENIHVAAGDLLKGVEIEADVIVANILADILIHLIDDAYRLVKDEGYLIMSGIIKDKWDMVRQSAESAGFFLETHMVQGEWNTCVFKKTKDISGVIGG

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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