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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 70585
  • locus tag: SP70585_1378 [new locus tag: SP70585_RS12595 ]
  • pan locus tag?: PNEUPAN000128000
  • symbol: SP70585_1378
  • pan gene symbol?: appD
  • synonym:
  • product: glutathione import ATP-binding protein GsiA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP70585_1378 [new locus tag: SP70585_RS12595 ]
  • symbol: SP70585_1378
  • product: glutathione import ATP-binding protein GsiA
  • replicon: chromosome
  • strand: -
  • coordinates: 1274380..1275939
  • length: 1560
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    ATGTTAGAAAAACTTGGAATTCATAATGCTGCAGAACGCATGAATGACTATCCACACCAA
    TTTAGTGGAGGGCAGCGTCAAAGAATAGTCATAGCGATTGCAATGGTATGTAATCCAGAT
    ATTCTAATTGCAGATGAACCAACAACTGCCCTTGATGTAACAATCCAAGCACAAATACTT
    GATTTACTTGATGATTTACGTAAAGAGCATGGAACTTCTATTATCTTAATTACTCACGAT
    TTAGGCGTTATTGCTCAAATTGCGGATGAAGTTGCAGTGATGTATGCTGGTGAAGTCGTT
    GAAGTTGGAACTGTAGCTCAGATCTTTGATCAACCTAAACACCCGTATACTCGTTCTCTA
    TTAAGATCTATTCCTAATCCTGAAAATATGGATAAAAAGCTACATGTTATCCAGGGGAGC
    GTACCTTCAATTTCTGAAATATCTGAAAAAGGATGCAGATTCGCAAATCGTATTCCATGG
    TTAGAAAAAGAACATCATGAAGAAGAACCTCAATTGCATGATTTAGGTGACGGACATTTT
    GTAAGGTGTTCTTGCTATAAACATTTCTTTTTCGAAGATAAGGAAGAAGAAACATTAGCG
    GAAAAACATGTAGGTAATGTTGTTTTAGAAGTAAAAAATATTAAAAAGTACTACTATCCT
    AAGAAGCAACTATTCAAGCCACTAGGTTCTCCGTTGAAAGCACTTGATGACGTATCTCTA
    GAGTTAAGAAAAGGAACTACTATTGGTATCGTAGGAGAGTCTGGAAGCGGTAAGAGTACG
    ATTGCGAAATCATTAATGAAACTCCATGATATTACAGATGGTGAAATCAATATTGATTTG
    AATGGGAAAACTCAAAATATTTATGGAATTAAACGTAAGGAAGATTTGGATTTCCGTAAG
    AAAGTTCAAATGGTATTCCAAGATCCTTATGCATCATTGAACCCAACTAAGAAAATTTAT
    AATTCATTTGATGAACCGATGATTGTCCATAATATTGGAAACAAAGAGGAACGCTTTGAA
    CGTATGAAAGAAGCCTTGAAGATGGTAAACGTGCCAGTTGAGTACTTGGAGCGTTATCCT
    CATGAATTTTCAGGCGGACAACGTCAACGTTTATGTATTGCTCGTGCCCTTTGTATGAAA
    CCAGAAATTTTAATTTTAGATGAACCTGTTTCAGCATTAGATCTATCTGTACAAGCGCAA
    GTTTTGAATTATCTTGTTGAAATCCAAAATAAAGAAGATTTGACTTATGTATTTATTTCT
    CATGACCTAGGTGTTGTGAAATACATGTGTGACTATCTATATGTTATTCATAAAGGACGT
    ATTGTAGAAGCTGGTTCTCGAGAAGATATCTACAATAACCCAATGCATATTTACACTAAA
    AAACTATTAGCTGCTATTCCAGAAGTTGATTATCACTTCAAAGAGGCATTGGCAACAAAA
    CGTAAAGAAAATGAAGTTGAATTTAAAGCACAGTACCATGAATTTTATGATGAAGATGGC
    CGTGCTTATGATCTTAAGCAGGTTTCACCAACACATTTTGTAGCGTTAAAACCAGAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP70585_1378 [new locus tag: SP70585_RS12595 ]
  • symbol: SP70585_1378
  • description: glutathione import ATP-binding protein GsiA
  • length: 519
  • theoretical pI: 6.15678
  • theoretical MW: 59422.8
  • GRAVY: -0.391137

⊟Function[edit | edit source]

  • reaction:
    EC 3.6.3.-?  ExPASy
  • TIGRFAM:
    Metabolism Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikD (TIGR02770; HMM-score: 353.6)
    Metabolism Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikE (TIGR02769; EC 3.6.3.24; HMM-score: 321.7)
    and 78 more
    Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04521; EC 3.6.3.-; HMM-score: 260.7)
    Metabolism Transport and binding proteins Amino acids, peptides and amines glycine betaine/L-proline transport ATP binding subunit (TIGR01186; HMM-score: 259.4)
    Metabolism Transport and binding proteins Anions phosphate ABC transporter, ATP-binding protein (TIGR00972; EC 3.6.3.27; HMM-score: 254.3)
    ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA (TIGR03005; HMM-score: 245.7)
    D-methionine ABC transporter, ATP-binding protein (TIGR02314; EC 3.6.3.-; HMM-score: 244.6)
    Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04520; EC 3.6.3.-; HMM-score: 233.5)
    Metabolism Transport and binding proteins Amino acids, peptides and amines choline ABC transporter, ATP-binding protein (TIGR03415; HMM-score: 219.6)
    Metabolism Transport and binding proteins Anions sulfate ABC transporter, ATP-binding protein (TIGR00968; EC 3.6.3.25; HMM-score: 217.8)
    Metabolism Transport and binding proteins Amino acids, peptides and amines polyamine ABC transporter, ATP-binding protein (TIGR01187; EC 3.6.3.31; HMM-score: 214.4)
    Metabolism Transport and binding proteins Amino acids, peptides and amines putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein (TIGR03265; HMM-score: 213.8)
    Metabolism Transport and binding proteins Anions phosphonate ABC transporter, ATP-binding protein (TIGR02315; EC 3.6.3.28; HMM-score: 206)
    Metabolism Transport and binding proteins Anions molybdate ABC transporter, ATP-binding protein (TIGR02142; EC 3.6.3.29; HMM-score: 198.5)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking lipoprotein releasing system, ATP-binding protein (TIGR02211; EC 3.6.3.-; HMM-score: 192.9)
    Metabolism Transport and binding proteins Other daunorubicin resistance ABC transporter, ATP-binding protein (TIGR01188; HMM-score: 189.9)
    ABC exporter ATP-binding subunit, DevA family (TIGR02982; HMM-score: 186.3)
    Cellular processes Cellular processes Cell division cell division ATP-binding protein FtsE (TIGR02673; HMM-score: 184.5)
    Metabolism Central intermediary metabolism Phosphorus compounds phosphonate C-P lyase system protein PhnK (TIGR02323; HMM-score: 183.1)
    2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT (TIGR03258; HMM-score: 181.9)
    Cellular processes Cellular processes Toxin production and resistance putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 181.8)
    Metabolism Transport and binding proteins Unknown substrate putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 181.8)
    Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 175.7)
    Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 175.7)
    Metabolism Energy metabolism Methanogenesis methyl coenzyme M reductase system, component A2 (TIGR03269; HMM-score: 173.3)
    Cellular processes Cellular processes Pathogenesis type I secretion system ATPase (TIGR03375; HMM-score: 172.4)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR03375; HMM-score: 172.4)
    Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 171.7)
    Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 171.7)
    Metabolism Transport and binding proteins Other antigen peptide transporter 2 (TIGR00958; HMM-score: 171.6)
    Metabolism Transport and binding proteins Cations and iron carrying compounds cobalt ABC transporter, ATP-binding protein (TIGR01166; HMM-score: 168.8)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 163)
    Metabolism Transport and binding proteins Other lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 163)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01846; HMM-score: 162.3)
    Metabolism Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtE (TIGR03410; HMM-score: 159.7)
    proposed F420-0 ABC transporter, ATP-binding protein (TIGR03873; HMM-score: 158.8)
    ABC transporter, permease/ATP-binding protein (TIGR02204; HMM-score: 158.5)
    Metabolism Transport and binding proteins Anions nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 153.2)
    Metabolism Transport and binding proteins Other nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 153.2)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking ABC-type bacteriocin transporter (TIGR01193; HMM-score: 153)
    Genetic information processing Protein fate Protein modification and repair ABC-type bacteriocin transporter (TIGR01193; HMM-score: 153)
    Metabolism Transport and binding proteins Other ABC-type bacteriocin transporter (TIGR01193; HMM-score: 153)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01842; HMM-score: 148.4)
    thiol reductant ABC exporter, CydD subunit (TIGR02857; HMM-score: 148.1)
    phosphonate C-P lyase system protein PhnL (TIGR02324; HMM-score: 145.9)
    Metabolism Transport and binding proteins Other thiamine ABC transporter, ATP-binding protein (TIGR01277; EC 3.6.3.-; HMM-score: 144.8)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system (TIGR03864; HMM-score: 143.3)
    Metabolism Transport and binding proteins Unknown substrate anchored repeat-type ABC transporter, ATP-binding subunit (TIGR03771; HMM-score: 143)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids glucan exporter ATP-binding protein (TIGR01192; EC 3.6.3.42; HMM-score: 138.4)
    thiol reductant ABC exporter, CydC subunit (TIGR02868; HMM-score: 137.3)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids D-xylose ABC transporter, ATP-binding protein (TIGR02633; EC 3.6.3.17; HMM-score: 133.8)
    Metabolism Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtD (TIGR03411; HMM-score: 129.9)
    lantibiotic protection ABC transporter, ATP-binding subunit (TIGR03740; HMM-score: 129.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other FeS assembly ATPase SufC (TIGR01978; HMM-score: 127.1)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 124.5)
    Metabolism Transport and binding proteins Other LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 124.5)
    Metabolism Transport and binding proteins Other pigment precursor permease (TIGR00955; HMM-score: 115)
    gliding motility-associated ABC transporter ATP-binding subunit GldA (TIGR03522; HMM-score: 110)
    Metabolism Transport and binding proteins Amino acids, peptides and amines oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain (TIGR01727; HMM-score: 108.2)
    ATP-binding cassette protein, ChvD family (TIGR03719; HMM-score: 94.4)
    Metabolism Transport and binding proteins Other multi drug resistance-associated protein (MRP) (TIGR00957; HMM-score: 92.1)
    Cellular processes Cellular processes Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 87.9)
    Metabolism Transport and binding proteins Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 87.9)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 84.7)
    Metabolism Transport and binding proteins Other heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 84.7)
    Metabolism Transport and binding proteins Other rim ABC transporter (TIGR01257; HMM-score: 64.8)
    Metabolism Transport and binding proteins Anions cystic fibrosis transmembrane conductor regulator (CFTR) (TIGR01271; EC 3.6.3.49; HMM-score: 63.6)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids peroxysomal long chain fatty acyl transporter (TIGR00954; HMM-score: 61.2)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit A (TIGR00630; EC 3.1.25.-; HMM-score: 57.3)
    Metabolism Transport and binding proteins Amino acids, peptides and amines cyclic peptide transporter (TIGR01194; HMM-score: 55.4)
    Metabolism Transport and binding proteins Other cyclic peptide transporter (TIGR01194; HMM-score: 55.4)
    Metabolism Transport and binding proteins Other pleiotropic drug resistance family protein (TIGR00956; HMM-score: 45.1)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides uridine kinase (TIGR00235; EC 2.7.1.48; HMM-score: 16.7)
    Metabolism Central intermediary metabolism Sulfur metabolism adenylyl-sulfate kinase (TIGR00455; EC 2.7.1.25; HMM-score: 15.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A dephospho-CoA kinase (TIGR00152; EC 2.7.1.24; HMM-score: 13.7)
    carbohydrate kinase, thermoresistant glucokinase family (TIGR01313; EC 2.7.1.-; HMM-score: 13.3)
    Cellular processes Cellular processes Pathogenesis type III secretion apparatus H+-transporting two-sector ATPase (TIGR02546; EC 3.6.3.14; HMM-score: 12.3)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type III secretion apparatus H+-transporting two-sector ATPase (TIGR02546; EC 3.6.3.14; HMM-score: 12.3)
    Unknown function General small GTP-binding protein domain (TIGR00231; HMM-score: 12.1)
    rad50 (TIGR00606; HMM-score: 11)
  • TheSEED  :
    • Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1)
    Membrane Transport ABC transporters ABC transporter oligopeptide (TC 3.A.1.5.1)  Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1)
  • PFAM:
    P-loop_NTPase (CL0023) ABC_tran; ABC transporter (PF00005; HMM-score: 163)
    and 28 more
    no clan defined oligo_HPY; Oligopeptide/dipeptide transporter, C-terminal region (PF08352; HMM-score: 86.5)
    P-loop_NTPase (CL0023) AAA_21; AAA domain, putative AbiEii toxin, Type IV TA system (PF13304; HMM-score: 39.5)
    SMC_N; RecF/RecN/SMC N terminal domain (PF02463; HMM-score: 33.1)
    AAA_22; AAA domain (PF13401; HMM-score: 25.6)
    TniB; Bacterial TniB protein (PF05621; HMM-score: 22.2)
    ABC_ATPase; ATPase of the ABC class (PF09818; HMM-score: 21.8)
    AAA_18; AAA domain (PF13238; HMM-score: 19.6)
    AAA_13; AAA domain (PF13166; HMM-score: 19.2)
    AAA_23; AAA domain (PF13476; HMM-score: 17.2)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 16.4)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 16.3)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 16.3)
    AAA_15; AAA ATPase domain (PF13175; HMM-score: 15.4)
    ATP-synt_ab; ATP synthase alpha/beta family, nucleotide-binding domain (PF00006; HMM-score: 15.3)
    Sigma54_activat; Sigma-54 interaction domain (PF00158; HMM-score: 15.3)
    PRK; Phosphoribulokinase / Uridine kinase family (PF00485; HMM-score: 14.9)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 14.9)
    MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 14.4)
    AAA_33; AAA domain (PF13671; HMM-score: 14.4)
    Septin; Septin (PF00735; HMM-score: 14.1)
    NB-ARC; NB-ARC domain (PF00931; HMM-score: 13.5)
    DUF87; Helicase HerA, central domain (PF01935; HMM-score: 13.5)
    Roc; Ras of Complex, Roc, domain of DAPkinase (PF08477; HMM-score: 13.2)
    AAA_24; AAA domain (PF13479; HMM-score: 12.8)
    RNA_helicase; RNA helicase (PF00910; HMM-score: 12.7)
    APS_kinase; Adenylylsulphate kinase (PF01583; HMM-score: 12.6)
    G-alpha; G-protein alpha subunit (PF00503; HMM-score: 12.2)
    NACHT; NACHT domain (PF05729; HMM-score: 11.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.04
    • Cytoplasmic Membrane Score: 9.96
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.1488
    • Cytoplasmic Membrane Score: 0.7571
    • Cell wall & surface Score: 0.0008
    • Extracellular Score: 0.0933
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.029082
    • TAT(Tat/SPI): 0.001214
    • LIPO(Sec/SPII): 0.002653
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MLEKLGIHNAAERMNDYPHQFSGGQRQRIVIAIAMVCNPDILIADEPTTALDVTIQAQILDLLDDLRKEHGTSIILITHDLGVIAQIADEVAVMYAGEVVEVGTVAQIFDQPKHPYTRSLLRSIPNPENMDKKLHVIQGSVPSISEISEKGCRFANRIPWLEKEHHEEEPQLHDLGDGHFVRCSCYKHFFFEDKEEETLAEKHVGNVVLEVKNIKKYYYPKKQLFKPLGSPLKALDDVSLELRKGTTIGIVGESGSGKSTIAKSLMKLHDITDGEINIDLNGKTQNIYGIKRKEDLDFRKKVQMVFQDPYASLNPTKKIYNSFDEPMIVHNIGNKEERFERMKEALKMVNVPVEYLERYPHEFSGGQRQRLCIARALCMKPEILILDEPVSALDLSVQAQVLNYLVEIQNKEDLTYVFISHDLGVVKYMCDYLYVIHKGRIVEAGSREDIYNNPMHIYTKKLLAAIPEVDYHFKEALATKRKENEVEFKAQYHEFYDEDGRAYDLKQVSPTHFVALKPE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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