PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 31-JAN-2014

⊟Summary

• organism: Streptococcus pneumoniae 70585
• locus tag: SP70585_1439 [new locus tag: SP70585_RS07130 ]
• pan locus tag^?: PNEUPAN002676000
• symbol: SP70585_1439
• pan gene symbol^?: pstS2
• synonym: pstS
• product: phosphate-binding protein PstS 1 (PBP 1)

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SP70585_1439 [new locus tag: SP70585_RS07130 ]
• symbol: SP70585_1439
• product: phosphate-binding protein PstS 1 (PBP 1)
• replicon: chromosome
• strand: -
• coordinates: 1335892..1336770
• length: 879
• essential: unknown

⊟Accession numbers

• Location: CP000918 (1335892..1336770) NCBI
• BioCyc: see SP70585_RS07130
• MicrobesOnline: 7477367 MicrobesOnline
• PneumoBrowse for strain D39V: SPV_1232 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  
  GTGAAAAAAAGAAAAAAGCTTGCTCTGTCTCTTATCGCTTTTTGGCTGACGGCTTGTTTA
  GTAGGCTGTGCTAGCTGGATTGATCGTGGAGAATCCATAACGGCTGTTGGCTCAACTGCC
  TTGCAACCCTTGGTTGAAGTAGCGGCAGATGAATTTGGCACGATCCATGTTGGAAAAACG
  GTCAATGTCCAAGGGGGAGGTTCTGGTACAGGCTTGTCCCAGGTTCAGTCTGGGGCAGTT
  GATATAGGAAACTCAGATGTATTTGCTGAGGAAAAAGACGGAATTGATGCTTCTGCTCTT
  GTTGACCACAAGGTCGCGGTAGCTGGCTTGGCTCTGATTGTCAATAAGGAGGTTGATGTT
  GATAACCTAACGACAGAGCAACTTCGTCAAATCTTCATAGGTGAGGTAACCAATTGGAAA
  GAGGTTGGTGGTAAGGACTTACCCATCTCTGTTATCAATCGGGCAGCCGGCTCTGGCTCT
  CGTGCTACCTTTGATACTGTCATTATGGAAGGTCAGTCTGCCATGCAAAGTCAGGAGCAG
  GATTCAAATGGAGCGGTAAAATCAATCGTATCAAAAAGTCCAGGAGCTATCTCTTATTTA
  TCTCTTACCTATATAGATGATTCGGTCAAAAGCATGAAGTTGAATGGCTATGACTTAAGT
  CCAGAAAATATAAGTAGCAATAATTGGCCCTTGTGGTCTTATGAGCATATGTATACATTG
  GGGCAGCCCAATGAGTTGGCTGCAGAATTTCTCAATTTTGTTCTCTCGGATGAGACCCAA
  GAAGGGATTGTCAAAGGATTGAAGTATATTCCGATTAAGGAAATGAAGGTTGAAAAAGAT
  GCTGCCGGAACTGTGACAGTGTTGGAAGGGAGACAATAA
  60
  120
  180
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  480
  540
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  720
  780
  840
  879
  

⊟Protein

⊟General

• locus tag: SP70585_1439 [new locus tag: SP70585_RS07130 ]
• symbol: SP70585_1439
• description: phosphate-binding protein PstS 1 (PBP 1)
• length: 292
• theoretical pI: 4.51194
• theoretical MW: 31201.1
• GRAVY: -0.0671233

⊟Function

• TIGRFAM:
  Metabolism Transport and binding proteins Anions phosphate binding protein (TIGR02136; HMM-score: 323.7)
  and 3 more
  Metabolism Transport and binding proteins Anions phosphate ABC transporter, phosphate-binding protein PstS (TIGR00975; HMM-score: 63.6)
  phosphate ABC transporter substrate-binding protein (TIGR04505; HMM-score: 40.3)
  CRISPR-associated protein Cas4/Csa1, subtype I-A/APERN (TIGR01896; HMM-score: 11.9)
• TheSEED  :
  • Phosphate ABC transporter, substrate-binding protein PstS
  Phosphorus Metabolism Phosphorus Metabolism - no subcategory High affinity phosphate transporter and control of PHO regulon  Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1)
  and 1 more
  Phosphorus Metabolism Phosphorus Metabolism - no subcategory Phosphate metabolism  Phosphate ABC transporter, periplasmic phosphate-binding protein PstS (TC 3.A.1.7.1)
• PFAM:
  PBP (CL0177) PBP_like_2; PBP superfamily domain (PF12849; HMM-score: 124)
  and 6 more
  PBP_like; PBP superfamily domain (PF12727; HMM-score: 74.7)
  SBP_bac_11; Bacterial extracellular solute-binding protein (PF13531; HMM-score: 32.3)
  SBP_bac_1; Bacterial extracellular solute-binding protein (PF01547; HMM-score: 20)
  SBP_bac_6; Bacterial extracellular solute-binding protein (PF13343; HMM-score: 15.9)
  SBP_bac_8; Bacterial extracellular solute-binding protein (PF13416; HMM-score: 13)
  no clan defined DUF4995; Domain of unknown function (PF16386; HMM-score: 11.7)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic Membrane
  • Cytoplasmic Score: 0.17
  • Cytoplasmic Membrane Score: 9.51
  • Cellwall Score: 0.16
  • Extracellular Score: 0.15
  • Internal Helix: 1
• DeepLocPro: Cytoplasmic Membrane
  • Cytoplasmic Score: 0.0002
  • Cytoplasmic Membrane Score: 0.7997
  • Cell wall & surface Score: 0.0096
  • Extracellular Score: 0.1906
• SignalP: Signal peptide LIPO(Sec/SPII) length 22 aa
  • SP(Sec/SPI): 0.010387
  • TAT(Tat/SPI): 0.000117
  • LIPO(Sec/SPII): 0.987945
  • Cleavage Site: CS pos: 22-23. LVG-CA. Pr: 0.5174
• predicted transmembrane helices (TMHMM): 1

⊟Accession numbers

• GI:
• RefSeq: ACO17057 NCBI
• UniProt: C1C7Z9 UniProt

⊟Protein sequence

• MKKRKKLALSLIAFWLTACLVGCASWIDRGESITAVGSTALQPLVEVAADEFGTIHVGKTVNVQGGGSGTGLSQVQSGAVDIGNSDVFAEEKDGIDASALVDHKVAVAGLALIVNKEVDVDNLTTEQLRQIFIGEVTNWKEVGGKDLPISVINRAAGSGSRATFDTVIMEGQSAMQSQEQDSNGAVKSIVSKSPGAISYLSLTYIDDSVKSMKLNGYDLSPENISSNNWPLWSYEHMYTLGQPNELAAEFLNFVLSDETQEGIVKGLKYIPIKEMKVEKDAAGTVTVLEGRQ

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: phoU1 < pstB1 < pstB2 < pstA1 < pstC1 < SP70585_1439

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_1232 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications