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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 70585
  • locus tag: SP70585_RS00870 [old locus tag: SP70585_0180 ]
  • pan locus tag?: PNEUPAN000065000
  • symbol: SP70585_RS00870
  • pan gene symbol?: rtgA
  • synonym:
  • product: peptidase domain-containing ABC transporter

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP70585_RS00870 [old locus tag: SP70585_0180 ]
  • symbol: SP70585_RS00870
  • product: peptidase domain-containing ABC transporter
  • replicon: chromosome
  • strand: +
  • coordinates: 155545..157764
  • length: 2220
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    ATGTTAAAAAAATATCCTTGTACGATGCAACATGATCAGTCAGATTGTGCTGCGGCAGTT
    GTTTCAACAGTTCTTTTATCTTACAAAAAGGAACTATCAATCATGAAGATTCGGGAAATT
    ATTGGTACAGACATGTATGGAACGACTGTCAGTGGTATTGTTTCAGGTCTGAATAAGTTG
    AATTTTACAGTAAAAGCTGTTCGAGTAGCACTGGAAGATTTGACTCCAAAATTAACATTT
    CCTGCGATTCTTCAAGTTAAGAATGATTTAGGTCAAAATCATTTTGTGGTACTACATAGT
    ATCAAAAGGAATAGTAAGTTCTACGTAGCAGACCCTGCTAGTGGCATACGCAAGATGTCA
    AGTGACGAACTGGGAGAAATTTATCAAGGTATTACTCTTTTTATGGTTCCAAATTCGGAT
    TTTGAAAGAGGGAAACTAAAGGGAAAAGGACTTCTTGATTTATTTGGAAGGTTAATTTTT
    AATCAAAAAGGATTGATTAGTACAGTCATATTAGCTTCCTTTGTTTTAAGTATCATTGGT
    ATTTTATCGAGTCTCTTTTCAAAAGTTATCATGGACGAGGTGATTCCATATGCTTTAAAA
    AATAGTCTGTATATGTTTTTGATAGTATTTGGAATAGTGTCGTTCTTACAGACTCTTCTA
    TCTGCATTTCGTCAGCACGTTCTTTTGTTTCTATCTCGAAAAATTGATATACCGGTTTTA
    ATGGGATATTATGACCATATTATTCATCTTCCTTATAGTTTTTTTGGAAGTCGTAGAGTT
    GGTGATGTTTTAACAAGATTTCAAGATGCGATGACGATAAAGAATGTGTTTACGTCAGTC
    TCTATTTCATTAGTCATGGATATCACCTTGTCAGTTATTAGTGCGGTTGTCCTTTGGACT
    ATTAATCAATCTTTATTTCTGATATTAGTTTTTATGGTTATTGTTAACATCATTCTTATA
    TACTGTTTTAAAAAGCCTTATAAAAAAATTAATCATGAACAAATGGAAGCAAATGGACTT
    CTTAATTCACAGTTAATTGAATCTATTCGTAACATTGATACCATTAAGTCTCAGCATGAT
    GAGGAACAACGTTTAAACAAAATTGAAGAAAAATTTGTTCATACTTTAGAAATTGGTTAT
    AAAGAGGGTGTTTTGCAGAATATTCAATCTACAATATCTTCAATGACCTCAACCATGGGT
    GGGTTATTATTTATGGGAGTGGGCGCCTTATTTATCATTGATGGAAAAATGACTATTGGG
    GACCTCTTGGTTTTTCAGACATTAAGTCAATATTTTACAGAACCTATTCAGAATTTAGTT
    GGCTTGCAGTTAACCTTTCAAGAGGTACAGGTTGCGGTTAGTCGGCTTCAAGAATTGATG
    GAAGTAGATCGTGAAGACATTGCCTTGGATTATAGTATTAGAGACTTCACCTTATGTGAT
    GACATTGAATTTAAAGATGTAACATTTGCCTATGGTTCACGCCCTCCTGTTATCAAGGAC
    TTTAATTTGCGAATTAAACAAGGAGAAAAAATAGCTTTTGTTGGAGAAAGCGGAGCAGGA
    AAAAGTACGCTAGTTCGTTTGTTATTAAGATTTATAAATCCGAGTGAGGGGAAAATTCGT
    ATAGGAGAAAATGACTTATCAGATCTTGACTATGGTAAACTACGTAAGAAAATTTCCTAC
    ATTCCTCAGACCATAGAACTCTTTACAGGGACAATTATTGATAATCTAAAAATTGGTAAT
    CCTTCTGTTACATATGAGGATATGGTGAGAGTTTGTCGTATTGTTGGTATTCATGATACG
    ATTCAACGTCTTCAAAATCGTTATGGCTCCTTTGTAGAAGAAGACGGTCAAAATTTCTCG
    GGTGGAGAGAAACAACGATTGGCTATTGCAAGAGCACTACTGAGTAAAGCTGATTTGTAT
    ATATTTGATGAGGCAACCTCTAACTTAGATTCATTTAGTGAACAGATTATTCAGGATTTA
    ATCTTTAATAAAATAATGGATAAGACAACAATTGTAGTAGCCCACAGGCTGTCTACAATT
    CTTCGATGTGATAAGATATGCTTTTTAGAAAATGGGACTATTGTGGAATATGGGACTCAT
    GAAGAACTAATGGCGAAAAATGGAAAGTATGCTAGAATGGTTGGTTTGCAGAGCGTTCAA
    GTGAATCAACAAATTCAGTCACAGGCTGTGTTAGATACAGAGGAGGTTACTTATGGCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP70585_RS00870 [old locus tag: SP70585_0180 ]
  • symbol: SP70585_RS00870
  • description: peptidase domain-containing ABC transporter
  • length: 739
  • theoretical pI: 6.94954
  • theoretical MW: 83310.5
  • GRAVY: 0.154668

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein fate Protein and peptide secretion and trafficking ABC-type bacteriocin transporter (TIGR01193; HMM-score: 566.3)
    Genetic information processing Protein fate Protein modification and repair ABC-type bacteriocin transporter (TIGR01193; HMM-score: 566.3)
    Metabolism Transport and binding proteins Other ABC-type bacteriocin transporter (TIGR01193; HMM-score: 566.3)
    Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 492.8)
    Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein (TIGR03796; HMM-score: 492.8)
    and 67 more
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01846; HMM-score: 421)
    Cellular processes Cellular processes Pathogenesis type I secretion system ATPase (TIGR03375; HMM-score: 401.1)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR03375; HMM-score: 401.1)
    Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 336)
    Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system ABC transporter, ATP-binding protein (TIGR03797; HMM-score: 336)
    ABC transporter, permease/ATP-binding protein (TIGR02204; HMM-score: 330.1)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 309)
    Metabolism Transport and binding proteins Other lipid A export permease/ATP-binding protein MsbA (TIGR02203; HMM-score: 309)
    Metabolism Transport and binding proteins Other antigen peptide transporter 2 (TIGR00958; HMM-score: 293.3)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion system ATPase (TIGR01842; HMM-score: 256.2)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids glucan exporter ATP-binding protein (TIGR01192; EC 3.6.3.42; HMM-score: 220.8)
    thiol reductant ABC exporter, CydD subunit (TIGR02857; HMM-score: 219.9)
    thiol reductant ABC exporter, CydC subunit (TIGR02868; HMM-score: 204.5)
    Metabolism Transport and binding proteins Other multi drug resistance-associated protein (MRP) (TIGR00957; HMM-score: 146.2)
    Metabolism Transport and binding proteins Amino acids, peptides and amines glycine betaine/L-proline transport ATP binding subunit (TIGR01186; HMM-score: 121.6)
    Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04520; EC 3.6.3.-; HMM-score: 119.4)
    Metabolism Transport and binding proteins Anions phosphate ABC transporter, ATP-binding protein (TIGR00972; EC 3.6.3.27; HMM-score: 115.7)
    Metabolism Transport and binding proteins Anions cystic fibrosis transmembrane conductor regulator (CFTR) (TIGR01271; EC 3.6.3.49; HMM-score: 114.3)
    Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04521; EC 3.6.3.-; HMM-score: 113.6)
    Metabolism Transport and binding proteins Anions phosphonate ABC transporter, ATP-binding protein (TIGR02315; EC 3.6.3.28; HMM-score: 108.1)
    Cellular processes Cellular processes Cell division cell division ATP-binding protein FtsE (TIGR02673; HMM-score: 101.4)
    Metabolism Transport and binding proteins Other daunorubicin resistance ABC transporter, ATP-binding protein (TIGR01188; HMM-score: 98)
    Cellular processes Cellular processes Toxin production and resistance putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 96.4)
    Metabolism Transport and binding proteins Unknown substrate putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 96.4)
    Metabolism Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikE (TIGR02769; EC 3.6.3.24; HMM-score: 95.7)
    Metabolism Transport and binding proteins Other thiamine ABC transporter, ATP-binding protein (TIGR01277; EC 3.6.3.-; HMM-score: 94.1)
    Metabolism Transport and binding proteins Anions molybdate ABC transporter, ATP-binding protein (TIGR02142; EC 3.6.3.29; HMM-score: 89.3)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking lipoprotein releasing system, ATP-binding protein (TIGR02211; EC 3.6.3.-; HMM-score: 88.9)
    Metabolism Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtE (TIGR03410; HMM-score: 88.7)
    D-methionine ABC transporter, ATP-binding protein (TIGR02314; EC 3.6.3.-; HMM-score: 86.4)
    ABC exporter ATP-binding subunit, DevA family (TIGR02982; HMM-score: 83.2)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 83.1)
    Metabolism Transport and binding proteins Other LPS export ABC transporter ATP-binding protein (TIGR04406; HMM-score: 83.1)
    2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT (TIGR03258; HMM-score: 81.3)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system (TIGR03864; HMM-score: 81.2)
    Metabolism Transport and binding proteins Amino acids, peptides and amines putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein (TIGR03265; HMM-score: 80.1)
    ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA (TIGR03005; HMM-score: 78.6)
    Metabolism Transport and binding proteins Anions sulfate ABC transporter, ATP-binding protein (TIGR00968; EC 3.6.3.25; HMM-score: 76.8)
    Metabolism Transport and binding proteins Cations and iron carrying compounds cobalt ABC transporter, ATP-binding protein (TIGR01166; HMM-score: 76.3)
    Metabolism Energy metabolism Methanogenesis methyl coenzyme M reductase system, component A2 (TIGR03269; HMM-score: 75.2)
    proposed F420-0 ABC transporter, ATP-binding protein (TIGR03873; HMM-score: 72.1)
    lantibiotic protection ABC transporter, ATP-binding subunit (TIGR03740; HMM-score: 71.9)
    gliding motility-associated ABC transporter ATP-binding subunit GldA (TIGR03522; HMM-score: 71.5)
    Cellular processes Cellular processes Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 71.3)
    Metabolism Transport and binding proteins Other nodulation ABC transporter NodI (TIGR01288; HMM-score: 71.3)
    Metabolism Transport and binding proteins Amino acids, peptides and amines polyamine ABC transporter, ATP-binding protein (TIGR01187; EC 3.6.3.31; HMM-score: 70.9)
    Metabolism Transport and binding proteins Anions nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 69.9)
    Metabolism Transport and binding proteins Other nitrate ABC transporter, ATP-binding proteins C and D (TIGR01184; HMM-score: 69.9)
    Metabolism Transport and binding proteins Amino acids, peptides and amines choline ABC transporter, ATP-binding protein (TIGR03415; HMM-score: 69.9)
    Metabolism Transport and binding proteins Unknown substrate anchored repeat-type ABC transporter, ATP-binding subunit (TIGR03771; HMM-score: 66.9)
    Metabolism Transport and binding proteins Amino acids, peptides and amines cyclic peptide transporter (TIGR01194; HMM-score: 66.3)
    Metabolism Transport and binding proteins Other cyclic peptide transporter (TIGR01194; HMM-score: 66.3)
    phosphonate C-P lyase system protein PhnL (TIGR02324; HMM-score: 65.4)
    Metabolism Transport and binding proteins Other pigment precursor permease (TIGR00955; HMM-score: 65.2)
    Metabolism Transport and binding proteins Cations and iron carrying compounds nickel import ATP-binding protein NikD (TIGR02770; HMM-score: 65.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other FeS assembly ATPase SufC (TIGR01978; HMM-score: 60.5)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 59.2)
    Metabolism Transport and binding proteins Other heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 59.2)
    Metabolism Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtD (TIGR03411; HMM-score: 57.4)
    ATP-binding cassette protein, ChvD family (TIGR03719; HMM-score: 57)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids D-xylose ABC transporter, ATP-binding protein (TIGR02633; EC 3.6.3.17; HMM-score: 56.1)
    Metabolism Transport and binding proteins Other rim ABC transporter (TIGR01257; HMM-score: 49.1)
    Metabolism Central intermediary metabolism Phosphorus compounds phosphonate C-P lyase system protein PhnK (TIGR02323; HMM-score: 48)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids peroxysomal long chain fatty acyl transporter (TIGR00954; HMM-score: 40.3)
    Metabolism Transport and binding proteins Other pleiotropic drug resistance family protein (TIGR00956; HMM-score: 30.4)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit A (TIGR00630; EC 3.1.25.-; HMM-score: 26)
    Genetic information processing Protein synthesis Other ribosome biogenesis GTP-binding protein YsxC (TIGR03598; HMM-score: 12.5)
  • TheSEED: see SP70585_0180
  • PFAM:
    ABC_membrane (CL0241) ABC_membrane; ABC transporter transmembrane region (PF00664; HMM-score: 140.5)
    P-loop_NTPase (CL0023) ABC_tran; ABC transporter (PF00005; HMM-score: 113.2)
    and 15 more
    Peptidase_CA (CL0125) Peptidase_C39; Peptidase C39 family (PF03412; HMM-score: 105.1)
    P-loop_NTPase (CL0023) SMC_N; RecF/RecN/SMC N terminal domain (PF02463; HMM-score: 25.2)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 19.4)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 18.2)
    AAA_22; AAA domain (PF13401; HMM-score: 17.4)
    AAA_15; AAA ATPase domain (PF13175; HMM-score: 16.7)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 16.4)
    MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 15.6)
    no clan defined DUF4446; Protein of unknown function (DUF4446) (PF14584; HMM-score: 15.4)
    Peptidase_CA (CL0125) Peptidase_C39_2; Peptidase_C39 like family (PF13529; HMM-score: 13.9)
    P-loop_NTPase (CL0023) TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 13.4)
    AAA_33; AAA domain (PF13671; HMM-score: 12.8)
    DUF87; Helicase HerA, central domain (PF01935; HMM-score: 12.5)
    no clan defined ETRAMP; Malarial early transcribed membrane protein (ETRAMP) (PF09716; HMM-score: 12.5)
    EzrA; Septation ring formation regulator, EzrA (PF06160; HMM-score: 11.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 4
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.9988
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0012
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.005392
    • TAT(Tat/SPI): 0.000296
    • LIPO(Sec/SPII): 0.001382
  • predicted transmembrane helices (TMHMM): 5

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MLKKYPCTMQHDQSDCAAAVVSTVLLSYKKELSIMKIREIIGTDMYGTTVSGIVSGLNKLNFTVKAVRVALEDLTPKLTFPAILQVKNDLGQNHFVVLHSIKRNSKFYVADPASGIRKMSSDELGEIYQGITLFMVPNSDFERGKLKGKGLLDLFGRLIFNQKGLISTVILASFVLSIIGILSSLFSKVIMDEVIPYALKNSLYMFLIVFGIVSFLQTLLSAFRQHVLLFLSRKIDIPVLMGYYDHIIHLPYSFFGSRRVGDVLTRFQDAMTIKNVFTSVSISLVMDITLSVISAVVLWTINQSLFLILVFMVIVNIILIYCFKKPYKKINHEQMEANGLLNSQLIESIRNIDTIKSQHDEEQRLNKIEEKFVHTLEIGYKEGVLQNIQSTISSMTSTMGGLLFMGVGALFIIDGKMTIGDLLVFQTLSQYFTEPIQNLVGLQLTFQEVQVAVSRLQELMEVDREDIALDYSIRDFTLCDDIEFKDVTFAYGSRPPVIKDFNLRIKQGEKIAFVGESGAGKSTLVRLLLRFINPSEGKIRIGENDLSDLDYGKLRKKISYIPQTIELFTGTIIDNLKIGNPSVTYEDMVRVCRIVGIHDTIQRLQNRYGSFVEEDGQNFSGGEKQRLAIARALLSKADLYIFDEATSNLDSFSEQIIQDLIFNKIMDKTTIVVAHRLSTILRCDKICFLENGTIVEYGTHEELMAKNGKYARMVGLQSVQVNQQIQSQAVLDTEEVTYG

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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