PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 15-DEC-2024

⊟Summary

• organism: Streptococcus pneumoniae 70585
• locus tag: SP70585_RS04835 [old locus tag: SP70585_0973 ]
• pan locus tag^?: PNEUPAN001915000
• symbol: tmk
• pan gene symbol^?: tmk
• synonym:
• product: dTMP kinase

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SP70585_RS04835 [old locus tag: SP70585_0973 ]
• symbol: tmk
• product: dTMP kinase
• replicon: chromosome
• strand: +
• coordinates: 900940..901578
• length: 639
• essential: unknown other strains

⊟Accession numbers

• Location: NC_012468 (900940..901578) NCBI
• BioCyc: SP70585_RS04835 BioCyc
• MicrobesOnline: see SP70585_0973
• PneumoBrowse for strain D39V: SPV_0825 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
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  601
  
  ATGTCAAAAGGATTTTTAGTCTCTCTTGAGGGACCAGAGGGAGCAGGCAAGACCAGTGTT
  TTAGAGGCTCTGCTACCAATTTTAGAGGAAAAAGGAGTAGAGGTGCTGACGACCCGTGAA
  CCTGGCGGAGTCTTGATTGGGGAGAAGATTCGGGAAGTGATTTTGGATCCAAGTCATACT
  CAGATGGATGCTAAAACAGAGCTACTTCTCTATATTGCCAGTCGCAGACAGCATTTGGTG
  GAAAAAGTTCTTCCAGCCCTTGAAGCTGGCAAGTTGGTCATCATGGATCGTTTTATCGAT
  AGTTCTGTTGCCTATCAGGGATTTGGTCGTGGCTTAGATATTGAAGCCATTGACTGGCTC
  AATCAGTTTGCGACAGATGGCCTCAAACCCGATTTGACACTCTATTTTGACATCGAGGTG
  GAAGAAGGACTGGCTCGTATTGCTGCTAATAGTGACCGCGAGGTTAATCGTTTGGATTTG
  GAAGGGTTGGACTTGCATAAAAAAGTTCGTCAAGGCTACCTTTCTCTTCTGGATAAAGAG
  GGAAATCGCATTGTCAAGATTGATGCTAGTCTCCCTTTGGAGCAAGTTGTGGAAACTACC
  AAGGCTGTCTTGTTTGACGGAATGGGCTTGGCCAAATGA
  60
  120
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  540
  600
  639
  

⊟Protein

⊟General

• locus tag: SP70585_RS04835 [old locus tag: SP70585_0973 ]
• symbol: Tmk
• description: dTMP kinase
• length: 212
• theoretical pI: 4.57125
• theoretical MW: 23352.8
• GRAVY: -0.0339623

⊟Function

• reaction:
  EC 2.7.4.9?  ExPASy
  dTMP kinase ATP + dTMP = ADP + dTDP
• TIGRFAM:
  Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions dTMP kinase (TIGR00041; EC 2.7.4.9; HMM-score: 200.5)
  and 5 more
  Metabolism Transport and binding proteins Unknown substrate anchored repeat-type ABC transporter, ATP-binding subunit (TIGR03771; HMM-score: 18)
  Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Molybdopterin molybdopterin-guanine dinucleotide biosynthesis protein B (TIGR00176; HMM-score: 15.7)
  thiol reductant ABC exporter, CydD subunit (TIGR02857; HMM-score: 12.2)
  Genetic information processing Protein fate Protein and peptide secretion and trafficking heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 11.8)
  Metabolism Transport and binding proteins Other heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 11.8)
• TheSEED: see SP70585_0973
• PFAM:
  P-loop_NTPase (CL0023) Thymidylate_kin; Thymidylate kinase (PF02223; HMM-score: 177.3)
  and 11 more
  AAA_28; AAA domain (PF13521; HMM-score: 23.2)
  AAA_16; AAA ATPase domain (PF13191; HMM-score: 17.8)
  AAA_30; AAA domain (PF13604; HMM-score: 16.4)
  MobB; Molybdopterin guanine dinucleotide synthesis protein B (PF03205; HMM-score: 15.3)
  dNK; Deoxynucleoside kinase (PF01712; HMM-score: 15.2)
  AAA_33; AAA domain (PF13671; HMM-score: 15.1)
  AAA_18; AAA domain (PF13238; HMM-score: 13.6)
  ABC_tran; ABC transporter (PF00005; HMM-score: 13.5)
  AAA_23; AAA domain (PF13476; HMM-score: 12.3)
  AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 11.7)
  T2SSE; Type II/IV secretion system protein (PF00437; HMM-score: 11.3)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 7.5
  • Cytoplasmic Membrane Score: 1.15
  • Cellwall Score: 0.62
  • Extracellular Score: 0.73
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9961
  • Cytoplasmic Membrane Score: 0.0002
  • Cell wall & surface Score: 0.0001
  • Extracellular Score: 0.0036
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.002564
  • TAT(Tat/SPI): 0.000237
  • LIPO(Sec/SPII): 0.000354
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000033362 NCBI
• UniProt: see SP70585_0973

⊟Protein sequence

• MSKGFLVSLEGPEGAGKTSVLEALLPILEEKGVEVLTTREPGGVLIGEKIREVILDPSHTQMDAKTELLLYIASRRQHLVEKVLPALEAGKLVIMDRFIDSSVAYQGFGRGLDIEAIDWLNQFATDGLKPDLTLYFDIEVEEGLARIAANSDREVNRLDLEGLDLHKKVRQGYLSLLDKEGNRIVKIDASLPLEQVVETTKAVLFDGMGLAK

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: tmk > SP70585_RS04840 > yabA > rsmI

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0825 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications