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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
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serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-OCT-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 70585
  • locus tag: SP70585_RS08140 [old locus tag: SP70585_1643 ]
  • pan locus tag?: PNEUPAN002985000
  • symbol: cmk
  • pan gene symbol?: cmk
  • synonym:
  • product: (d)CMP kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP70585_RS08140 [old locus tag: SP70585_1643 ]
  • symbol: cmk
  • product: (d)CMP kinase
  • replicon: chromosome
  • strand: -
  • coordinates: 1518384..1519055
  • length: 672
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    ATGAAAACAATTCAAATTGCTATTGATGGTCCTGCTTCCAGCGGTAAGAGTACGGTCGCA
    AAGATTATTGCTAAGGATTTTGGATTCACCTACCTTGATACAGGAGCTATGTATCGTGCA
    GTGACCTATATGGCTCTTAAGAACCAATTAGGAGTTGAAGAAGTCGAAGCCCTTCTAGCC
    TTGTTGGACCAGCATCCAATCAGCTTTGGACGTTCAGAAACTGGAGACCAGCTTGTTTTT
    GTAGGAGATGTGGATATTACCCATCCTATCCGTGAAAATGAAGTGACCAATCATGTTTCT
    GCTATTGCAGCAATTCCTCAAGTGCGTGAGAAACTAGTTTCTCTCCAACAAGAAATTGCC
    CAGCAAGGCGGGATTGTTATGGATGGTCGCGATATTGGAACTGTTGTATTGCCGCAAGCA
    GAATTGAAAATTTTCCTAGTAGCTTCTGTTGATGAGAGAGCAGAGCGTCGTTACAAGGAA
    AATATTGCCAAGGGAATTGAAACAGACCTTGAAACCCTAAAAAAGGAAATTGCTGCGCGT
    GACTACAAGGATAGTCATCGTGAGACTTCTCCTCTCAAACAAGCAGAGGATGCTGTCTAC
    CTTGATACAACTGGTTTGAACATTCAAGAAGTAGTTGAAAAAATCAAAGCAGAAGCTGAA
    AAAAGAATGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    672

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP70585_RS08140 [old locus tag: SP70585_1643 ]
  • symbol: Cmk
  • description: (d)CMP kinase
  • length: 223
  • theoretical pI: 4.81464
  • theoretical MW: 24624.9
  • GRAVY: -0.234978

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.4.25?  ExPASy
    (d)CMP kinase ATP + (d)CMP = ADP + (d)CDP
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions cytidylate kinase (TIGR00017; EC 2.7.4.14; HMM-score: 266.3)
    and 8 more
    putative cytidylate kinase (TIGR02173; EC 2.7.4.14; HMM-score: 48.4)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions adenylate kinase (TIGR01351; EC 2.7.4.-; HMM-score: 19.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pantothenate and coenzyme A dephospho-CoA kinase (TIGR00152; EC 2.7.1.24; HMM-score: 16.1)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides uridine kinase (TIGR00235; EC 2.7.1.48; HMM-score: 15.7)
    adenylate kinase (TIGR01360; EC 2.7.4.3; HMM-score: 14.7)
    UMP-CMP kinase family (TIGR01359; EC 2.7.4.-; HMM-score: 14)
    carbohydrate kinase, thermoresistant glucokinase family (TIGR01313; EC 2.7.1.-; HMM-score: 13.4)
    nicotinamide-nucleotide adenylyltransferase (TIGR01526; EC 2.7.7.1; HMM-score: 12.1)
  • TheSEED: see SP70585_1643
  • PFAM:
    P-loop_NTPase (CL0023) Cytidylate_kin; Cytidylate kinase (PF02224; HMM-score: 259.4)
    and 13 more
    Cytidylate_kin2; Cytidylate kinase-like family (PF13189; HMM-score: 35.8)
    AAA_18; AAA domain (PF13238; HMM-score: 26.9)
    SKI; Shikimate kinase (PF01202; HMM-score: 20.8)
    AAA_17; AAA domain (PF13207; HMM-score: 20.7)
    ADK; Adenylate kinase (PF00406; HMM-score: 19.4)
    dNK; Deoxynucleoside kinase (PF01712; HMM-score: 19)
    AAA_33; AAA domain (PF13671; HMM-score: 16.6)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 14)
    ABC_tran; ABC transporter (PF00005; HMM-score: 13.9)
    no clan defined TPR_MLP1_2; TPR/MLP1/MLP2-like protein (PF07926; HMM-score: 13.2)
    P-loop_NTPase (CL0023) AAA_28; AAA domain (PF13521; HMM-score: 13.2)
    no clan defined SASP; Small, acid-soluble spore proteins, alpha/beta type (PF00269; HMM-score: 12.6)
    P-loop_NTPase (CL0023) CobU; Cobinamide kinase / cobinamide phosphate guanyltransferase (PF02283; HMM-score: 11.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006486
    • TAT(Tat/SPI): 0.000345
    • LIPO(Sec/SPII): 0.000761
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKTIQIAIDGPASSGKSTVAKIIAKDFGFTYLDTGAMYRAVTYMALKNQLGVEEVEALLALLDQHPISFGRSETGDQLVFVGDVDITHPIRENEVTNHVSAIAAIPQVREKLVSLQQEIAQQGGIVMDGRDIGTVVLPQAELKIFLVASVDERAERRYKENIAKGIETDLETLKKEIAARDYKDSHRETSPLKQAEDAVYLDTTGLNIQEVVEKIKAEAEKRM

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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