From PneumoWiki
Jump to navigation Jump to search
PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 15-OCT-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 70585
  • locus tag: SP70585_RS08760 [old locus tag: SP70585_1764 ]
  • pan locus tag?: PNEUPAN003133000
  • symbol: SP70585_RS08760
  • pan gene symbol?: scrR
  • synonym:
  • product: LacI family DNA-binding transcriptional regulator

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP70585_RS08760 [old locus tag: SP70585_1764 ]
  • symbol: SP70585_RS08760
  • product: LacI family DNA-binding transcriptional regulator
  • replicon: chromosome
  • strand: +
  • coordinates: 1638164..1639129
  • length: 966
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGGTCGCAAAACTAACTGATGTCGCCAAACTTGCAGGCGTCAGTTCTACTACCGTTTCT
    CGGGTTATCAATAAAAAAGGGTATCTATCTGAGAAAACCATCCGAAAAGTCAATGAAGCC
    ATGCGAGAATTGGGCTATAAACCCAACAACCTGGCTCGTAGTCTGCAAGGAAAATCAGCT
    AAGTTAATCGGCTTGATTTTCCCCAATATTTCCAATGTTTTCTATGCAGAATTGATTGAT
    AAATTGGAACACCAACTCTTCAAAAATGGTTACAAGACCATCATCTGCAACAGTGAACAT
    GATTCTGAGAAGGAACGCGAATACATCGAAATGTTGGAAGCCAATCAGGTGGACGGCATC
    ATTTCTGGTAGTCACAACCTAGGAATCGAAGACTACAATCGTGTGACAGCGCCGATTATT
    TCCTTTGACCGAAACCTATCGCCAGACATCCCTGTCGTCTCCTCTGACAACTATGCTGGT
    GGGGTTCTTGCTGCCCAAACCTTGGTCAAGACAGGTGCCCAGTCTATCATCATGATTACA
    GGGAATGACAATTCTAATTCGCCAACCGGACTGCGCCACGCTGGTTTTGCATCCGTACTC
    CCAAAAGCTCCTATTATCAATGTTTCCAGTGACTTTTCTCCCGTCAGAAAAGAAATGGAA
    ATCAAGAATATCTTGACCCGGGAAAAACCAGATGCCATTTTTGCTTCGGATGATTTGACA
    GCTATTCTGGTCATTAAAATCGCTCAAGAATTGGGCATTTCTGTCCCAAAAGAGCTCAAG
    GTCATCGGCTATGATGGGACCTACTTTATCGAAAATTACTACCCTCAATTGGCTACTATC
    AAGCAACCTTTGGAAGAGATTGCTTGTCTCACTATTGATCTTCTCTTGCAAAAGATTGAA
    GGCAAGGAAGTCGCCACAACTGGTTACTTCTTACCAGTTACGCTATTACCAGGAAAAAGT
    ATTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    966

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP70585_RS08760 [old locus tag: SP70585_1764 ]
  • symbol: SP70585_RS08760
  • description: LacI family DNA-binding transcriptional regulator
  • length: 321
  • theoretical pI: 6.5354
  • theoretical MW: 35202.3
  • GRAVY: -0.0607477

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Regulatory functions DNA interactions catabolite control protein A (TIGR01481; HMM-score: 173.7)
    Signal transduction Regulatory functions DNA interactions D-fructose-responsive transcription factor (TIGR02417; HMM-score: 146.4)
    and 6 more
    Signal transduction Regulatory functions DNA interactions trehalose operon repressor (TIGR02405; HMM-score: 101.4)
    Signal transduction Regulatory functions DNA interactions transcriptional repressor BetI (TIGR03384; HMM-score: 12.8)
    Genetic information processing Mobile and extrachromosomal element functions Other addiction module antidote protein, HigA family (TIGR02607; HMM-score: 11.6)
    Signal transduction Regulatory functions DNA interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 11.6)
    Signal transduction Regulatory functions Protein interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 11.6)
    Genetic information processing Transcription Transcription factors RNA polymerase sigma-54 factor (TIGR02395; HMM-score: 10.6)
  • TheSEED: see SP70585_1764
  • PFAM:
    Periplas_BP (CL0144) Peripla_BP_3; Periplasmic binding protein-like domain (PF13377; HMM-score: 86)
    HTH (CL0123) LacI; Bacterial regulatory proteins, lacI family (PF00356; HMM-score: 71.6)
    Periplas_BP (CL0144) Peripla_BP_4; Periplasmic binding protein domain (PF13407; HMM-score: 70.3)
    and 7 more
    Peripla_BP_1; Periplasmic binding proteins and sugar binding domain of LacI family (PF00532; HMM-score: 64)
    HTH (CL0123) HTH_3; Helix-turn-helix (PF01381; HMM-score: 20.6)
    HTH_23; Homeodomain-like domain (PF13384; HMM-score: 13.4)
    HTH_26; Cro/C1-type HTH DNA-binding domain (PF13443; HMM-score: 13)
    HTH_Tnp_ISL3; Helix-turn-helix domain of transposase family ISL3 (PF13542; HMM-score: 13)
    Sigma54_DBD; Sigma-54, DNA binding domain (PF04552; HMM-score: 12.7)
    HTH_10; HTH DNA binding domain (PF04967; HMM-score: 12.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by ScrR*, TF important in Sucrose utilization: see SP70585_1764

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.008259
    • TAT(Tat/SPI): 0.001584
    • LIPO(Sec/SPII): 0.001934
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MVAKLTDVAKLAGVSSTTVSRVINKKGYLSEKTIRKVNEAMRELGYKPNNLARSLQGKSAKLIGLIFPNISNVFYAELIDKLEHQLFKNGYKTIICNSEHDSEKEREYIEMLEANQVDGIISGSHNLGIEDYNRVTAPIISFDRNLSPDIPVVSSDNYAGGVLAAQTLVKTGAQSIIMITGNDNSNSPTGLRHAGFASVLPKAPIINVSSDFSPVRKEMEIKNILTREKPDAIFASDDLTAILVIKIAQELGISVPKELKVIGYDGTYFIENYYPQLATIKQPLEEIACLTIDLLLQKIEGKEVATTGYFLPVTLLPGKSI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Ramkumar Iyer, Andrew Camilli
Sucrose metabolism contributes to in vivo fitness of Streptococcus pneumoniae.
Mol Microbiol: 2007, 66(1);1-13
[PubMed:17880421] [WorldCat.org] [DOI] (P p)

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=SP70585_RS08760&oldid=28669"