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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-JAN-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_0038 [new locus tag: SPAP_RS00185 ]
  • pan locus tag?: PNEUPAN000408000
  • symbol: SPAP_0038
  • pan gene symbol?: dnaC_1
  • synonym:
  • product: DNA replication protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_0038 [new locus tag: SPAP_RS00185 ]
  • symbol: SPAP_0038
  • product: DNA replication protein
  • replicon: chromosome
  • strand: +
  • coordinates: 30547..31317
  • length: 771
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: CP002121 (30547..31317) NCBI
  • BioCyc: see SPAP_RS00185
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGGTAGACAATGTGTTTGAGGAAATCGCCTTATCTTATCGTAGGAATACAGAACAACAA
    GAAGAGTTCTGCGAAAAGCATAACATCCCTTTGATAAAGATATTGAGGACCGAGAGTGTT
    GTATGTCGCATGTGTGAATCTGAGCGGATTCATGAAGAAAATCAGGAAAGAGTGAATGAA
    CTGGCTAATGCTGAGAATGAGCGAGAGAGGAAATACTATCTTGAAAAGTTCTCTCTTTAT
    GATGAAGTTTTGAAAAATGCTACTTTGGACAATTTTGAAACACCAACCGAAAAAGAAGCG
    GAAAAGCTAGCTTTTGCAAAGAGGATTTGTCGTGAGTGGTCTGAGGGTGCTAGGAACAAC
    ATCGTGTTACAAGGAGAAGCTGGAACAGGTAAGAGCCATTTGGCTTTTGCTATGGTTAAG
    GCTCTATCTGAGTACACGAAAGAGATTGCTATTTTTATTAACGTAACTGACTTGCTGATG
    AAGATTAAAGCTGATTTTAGTCAGGAAGAGTTTCTGGTCAATAAAATTGCTAGTGCTAAG
    TTCTTGGTTTTGGATGATTTAGGAATGGAAAAAGATAGCGAATGGTCATTTACTATTCTC
    TACAATATCTTGAATAAGCGTTCAAACACAATCATTACCACAAATTTGATTTCTACCGAT
    ATTCAAAAAAGATATGGCAGACCTTTCATGTCCAGACTAATGAAGGGTGTAGATAAAGAC
    CATTTGATGGTTTTCAATGATTTGACAAACAAGCGAAAGCAATATTTTTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    771

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_0038 [new locus tag: SPAP_RS00185 ]
  • symbol: SPAP_0038
  • description: DNA replication protein
  • length: 256
  • theoretical pI: 5.53109
  • theoretical MW: 30038.1
  • GRAVY: -0.519141

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DnaA regulatory inactivator Hda (TIGR03420; HMM-score: 32.5)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair chromosomal replication initiator protein DnaA (TIGR00362; HMM-score: 30.2)
    and 6 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair orc1/cdc6 family replication initiation protein (TIGR02928; HMM-score: 20.1)
    Metabolism Energy metabolism Sugars L-rhamnose mutarotase (TIGR02625; EC 5.1.3.-; HMM-score: 14.7)
    Cellular processes Cellular processes Conjugation P-type conjugative transfer ATPase TrbB (TIGR02782; HMM-score: 12.9)
    Genetic information processing Protein fate Degradation of proteins, peptides, and glycopeptides putative ATP-dependent protease (TIGR00764; HMM-score: 12.5)
    KaiC domain protein, PAE1156 family (TIGR03881; HMM-score: 12.4)
    Cellular processes Cellular processes Toxin production and resistance TOMM system kinase/cyclase fusion protein (TIGR03903; HMM-score: 10)
  • TheSEED  :
    • DNA replication protein DnaC
    DNA Metabolism DNA replication DNA-replication  DNA replication protein DnaC
  • PFAM:
    P-loop_NTPase (CL0023) IstB_IS21; IstB-like ATP binding protein (PF01695; HMM-score: 47.2)
    and 25 more
    RNA_helicase; RNA helicase (PF00910; HMM-score: 22.4)
    AAA_5; AAA domain (dynein-related subfamily) (PF07728; HMM-score: 22.2)
    DUF815; Protein of unknown function (DUF815) (PF05673; HMM-score: 20.9)
    ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 20.4)
    Bac_DnaA; Bacterial dnaA protein (PF00308; HMM-score: 19.9)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 17.9)
    AAA_14; AAA domain (PF13173; HMM-score: 17.7)
    DUF2075; Schlafen group 3, DNA/RNA helicase domain (PF09848; HMM-score: 17.2)
    TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 16.7)
    AAA_18; AAA domain (PF13238; HMM-score: 16)
    AAA_22; AAA domain (PF13401; HMM-score: 15.9)
    Sigma54_activat; Sigma-54 interaction domain (PF00158; HMM-score: 15.8)
    NACHT; NACHT domain (PF05729; HMM-score: 15.6)
    DAP3; Mitochondrial ribosomal death-associated protein 3 (PF10236; HMM-score: 15.5)
    Parvo_NS1; Parvovirus non-structural protein NS1 (PF01057; HMM-score: 15.3)
    DUF5906; Family of unknown function (DUF5906) (PF19263; HMM-score: 14.9)
    PhoH; PhoH-like protein (PF02562; HMM-score: 14.2)
    no clan defined RPAP1_N; RPAP1-like, N-terminal (PF08621; HMM-score: 14)
    P-loop_NTPase (CL0023) CbiA; CobQ/CobB/MinD/ParA nucleotide binding domain (PF01656; HMM-score: 13.8)
    Mg_chelatase; Magnesium chelatase, subunit ChlI (PF01078; HMM-score: 13.2)
    AAA_30; AAA domain (PF13604; HMM-score: 13)
    AAA_7; P-loop containing dynein motor region (PF12775; HMM-score: 12.9)
    TIP49; TIP49 P-loop domain (PF06068; HMM-score: 12.7)
    NB-ARC; NB-ARC domain (PF00931; HMM-score: 12.5)
    T2SSE; Type II/IV secretion system protein (PF00437; HMM-score: 12.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9926
    • Cytoplasmic Membrane Score: 0.0011
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0062
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002584
    • TAT(Tat/SPI): 0.00064
    • LIPO(Sec/SPII): 0.000921
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADM83632 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MVDNVFEEIALSYRRNTEQQEEFCEKHNIPLIKILRTESVVCRMCESERIHEENQERVNELANAENERERKYYLEKFSLYDEVLKNATLDNFETPTEKEAEKLAFAKRICREWSEGARNNIVLQGEAGTGKSHLAFAMVKALSEYTKEIAIFINVTDLLMKIKADFSQEEFLVNKIASAKFLVLDDLGMEKDSEWSFTILYNILNKRSNTIITTNLISTDIQKRYGRPFMSRLMKGVDKDHLMVFNDLTNKRKQYF

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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