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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-JAN-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_0083 [new locus tag: SPAP_RS00400 ]
  • pan locus tag?: PNEUPAN000656000
  • symbol: SPAP_0083
  • pan gene symbol?: polA
  • synonym:
  • product: DNA polymerase I - 3'-5' exonuclease and polymerase domains

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_0083 [new locus tag: SPAP_RS00400 ]
  • symbol: SPAP_0083
  • product: DNA polymerase I - 3'-5' exonuclease and polymerase domains
  • replicon: chromosome
  • strand: +
  • coordinates: 66594..69263
  • length: 2670
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    ATGGTATTTTTTGATTCTTTCCTTTATAATGGGTGTATGGATAAGAAAAAATTATTATTG
    ATTGATGGGTCTTCTGTAGCTTTTCGGGCGTTTTTTGCGCTGTATCAGCAGTTGGACCGT
    TTTAAGAATGCGGCTGGTTTGCATACCAATGCGATTTATGGTTTTCAGTTGATGTTGAGT
    CATTTGTTGGAGCGGGTTGAGCCGAGTCATATTTTGGTGGCTTTTGATGCGGGAAAGACG
    ACCTTCCGGACAGAGATGTATGCGGACTATAAGGGTGGTCGGGCCAAGACTCCTGATGAG
    TTTCGTGAGCAATTTCCTTTCATTCGTGAGTTGCTGGATCATATGGGGATTCGTCACTAT
    GAGCTGGCTCAGTATGAGGCGGATGACATCATTGGGACGCTGGATAAGCTAGCAGAGCAG
    GATGGTTTTGATATTACCATTGTCAGTGGGGACAAGGATTTGATTCAGCTGACGGATGAG
    CATACGGTGGTTGAAATTTCCAAGAAAGGTGTGGCTGAGTTTGAGGCCTTTACGCCAGAT
    TACCTCATGGAAGAAATGGGCCTCACACCAGCTCAGTTTATCGATCTCAAGGCGCTCATG
    GGTGATAAGTCGGATAATATCCCTGGGGTGACCAAAGTCGGTGAAAAGACGGGTATTAAG
    CTCTTGCTGGAGCATGGTTCGCTTGAGGGGATTTATGAAAATATTGATGGAATGAAGACT
    TCTAAGATGAAGGAAAATCTCATCAATGACAAGGAACAGGCCTTTTTGTCTAAAACACTA
    GCGACCATTGATACCAAGGCACCGATTGCGATTGGTTTAGAGGACTTGGTCTATAGTGGT
    CCAGATGTTGAAAATCTTGGGAAATTCTACGATGAGATGGGCTTCAAACAGCTAAAGCAG
    GCTTTAAATGTGTCGTCAGCTGATGTGTCTGAGAGTTTGGATTTTACTATTGTTGACCAA
    ATCAGTCAAGATATGCTGAGTGAAGAGTCTATCTTCCACTTTGAGCTTTTTGGTGAGAAT
    TACCATACGGATAATTTGGTTGGATTTGCCTGGTCTTGTGGGGATAAGCTCTATGCCACA
    GACAAGCTTGAGCTGTTGCAAGACCCGATTTTCAAGGATTTCTTAGAAAAAACATCTCTG
    AGAGTTTATGACTTTAAGAAGGTTAAAGTTCTTTTGCAACGTTTTGGTGTGGATTTGCAG
    GCGCCTGCTTTTGACATCCGTTTGGCTAAATACCTCCTTTCGACTGTGGAGGACAATGAA
    ATTGCGACCATCGCTAGTCTTTATGGTCAGACTTACTTGGTTGATGATGAAACTTTCTAC
    GGTAAGGGTGTTAAAAAGGCCATTCCTGAACGTGAGAAATTCTTGGAACACTTAGCTTGT
    AAACTTGCTGTTTTGGTAGAAACAGAGCCTATTTTACTTGAAAAACTCAGCGAAAATGGG
    CAATTAGAGCTTCTTTATGATATGGAGCAACCTCTGGCTTTTGTCCTTGCCAAGATGGAA
    ATTGCTGGGATTATGGTCAAGAAAGAGACCTTGCTTGAGATGCAGGCTGAAAATGAGCTT
    GTCATTGAAAAACTGACTCAAGAGATTTACGAGCTGGCTGGTGAGGAGTTTAATGTCAAC
    TCGCCTAAGCAGTTGGGCGTGCTTCTCTTTGAGAAATTGGGACTTCCTCTAGAATACACT
    AAGAAAACCAAGACAGGTTATTCGACAGCAGTGGATGTTTTGGAGCGTCTCGCTCCTATT
    GCTCCGATTGTTAAGAAAATCCTGGATTACCGTCAAATTGCTAAGATTCAATCTACTTAT
    GTAATTGGCTTGCAGGACTGGATTTTGGCTGATGGAAAGATTCATACTCGCTATGTGCAG
    GATTTGACCCAGACCGGGCGTTTGTCTAGTGTGGATCCAAACTTGCAAAATATTCCTGCC
    CGATTGGAACAGGGGCGCTTGATTCGGAAGGCTTTTGTGCCAGAGTGGGAGGATAGTGTG
    CTACTCAGCTCTGACTATTCACAGATTGAATTGCGCGTTTTGGCGCATATTTCTAAGGAT
    GAGCACTTGATTAAGGCCTTCCAAGAGGGGGCAGATATCCATACTTCGACAGCCATGCGG
    GTCTTTGGCATTGAGCGTCCTGATGATGTGACTGCAAACGACCGTCGCAATGCCAAGGCA
    GTTAACTTTGGAGTGGTTTATGGGATTTCAGACTTTGGCTTGTCTAATAATTTGGGAATT
    AGTCGTAAGGAAGCCAAAGCCTACATTGATACCTACTTTGAACGTTTTCCAGGTATTAAA
    AACTACATGGATGAAGTGGTGCGGGAGGCGCGTGATAAGGGCTATGTAGAGACCCTCTTT
    AAGCGTCGCCGTGAGTTGCCAGATATCAATTCGCGCAACTTCAATATTCGTGGTTTTGCG
    GAACGAACTGCTATCAACTCACCTATCCAGGGTTCGGCAGCAGATATTCTCAAGATTGCC
    ATGATTCAGCTGGATAAAGCCTTGGTTGCAGGTGGTTATCAGACTAAGATGCTGTTACAA
    GTGCACGATGAAATCGTCCTTGAAGTGCCTAAATCTGAATTGGTAGAGATGAAAAAATTG
    GTGAAACAAACCATGGAAGAAGCCATTCAACTCAGTGTTCCTCTTATCGCAGATGAGAAT
    GAAGGGGCAACCTGGTACGAGGCTAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2670

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_0083 [new locus tag: SPAP_RS00400 ]
  • symbol: SPAP_0083
  • description: DNA polymerase I - 3'-5' exonuclease and polymerase domains
  • length: 889
  • theoretical pI: 4.68853
  • theoretical MW: 100635
  • GRAVY: -0.200562

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase I (TIGR00593; EC 2.7.7.7; HMM-score: 1045)
    and 1 more
    flap structure-specific endonuclease (TIGR03674; EC 3.1.-.-; HMM-score: 18.1)
  • TheSEED  :
    • DNA polymerase I (EC 2.7.7.7)
    DNA Metabolism DNA repair DNA Repair Base Excision  DNA polymerase I (EC 2.7.7.7)
    and 1 more
    DNA Metabolism DNA replication DNA-replication  DNA polymerase I (EC 2.7.7.7)
  • PFAM:
    no clan defined DNA_pol_A; DNA polymerase family A (PF00476; HMM-score: 498.7)
    and 4 more
    PIN (CL0280) 5_3_exonuc_N; 5'-3' exonuclease, N-terminal resolvase-like domain (PF02739; HMM-score: 166.5)
    5_3_exonuc_C (CL0464) 5_3_exonuc; 5'-3' exonuclease, C-terminal SAM fold (PF01367; HMM-score: 113.4)
    S11_L18p (CL0267) baeRF_family10; Bacterial archaeo-eukaryotic release factor family 10 (PF18854; HMM-score: 12.3)
    no clan defined Mt_ATP_synt; Mitochondrial ATP synthase subunit (PF15704; HMM-score: 10.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002754
    • TAT(Tat/SPI): 0.000814
    • LIPO(Sec/SPII): 0.001088
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ADM83677 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MVFFDSFLYNGCMDKKKLLLIDGSSVAFRAFFALYQQLDRFKNAAGLHTNAIYGFQLMLSHLLERVEPSHILVAFDAGKTTFRTEMYADYKGGRAKTPDEFREQFPFIRELLDHMGIRHYELAQYEADDIIGTLDKLAEQDGFDITIVSGDKDLIQLTDEHTVVEISKKGVAEFEAFTPDYLMEEMGLTPAQFIDLKALMGDKSDNIPGVTKVGEKTGIKLLLEHGSLEGIYENIDGMKTSKMKENLINDKEQAFLSKTLATIDTKAPIAIGLEDLVYSGPDVENLGKFYDEMGFKQLKQALNVSSADVSESLDFTIVDQISQDMLSEESIFHFELFGENYHTDNLVGFAWSCGDKLYATDKLELLQDPIFKDFLEKTSLRVYDFKKVKVLLQRFGVDLQAPAFDIRLAKYLLSTVEDNEIATIASLYGQTYLVDDETFYGKGVKKAIPEREKFLEHLACKLAVLVETEPILLEKLSENGQLELLYDMEQPLAFVLAKMEIAGIMVKKETLLEMQAENELVIEKLTQEIYELAGEEFNVNSPKQLGVLLFEKLGLPLEYTKKTKTGYSTAVDVLERLAPIAPIVKKILDYRQIAKIQSTYVIGLQDWILADGKIHTRYVQDLTQTGRLSSVDPNLQNIPARLEQGRLIRKAFVPEWEDSVLLSSDYSQIELRVLAHISKDEHLIKAFQEGADIHTSTAMRVFGIERPDDVTANDRRNAKAVNFGVVYGISDFGLSNNLGISRKEAKAYIDTYFERFPGIKNYMDEVVREARDKGYVETLFKRRRELPDINSRNFNIRGFAERTAINSPIQGSAADILKIAMIQLDKALVAGGYQTKMLLQVHDEIVLEVPKSELVEMKKLVKQTMEEAIQLSVPLIADENEGATWYEAK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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