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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 22-FEB-2023

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_RS04945 [old locus tag: SPAP_0995 ]
  • pan locus tag?: PNEUPAN001960000
  • symbol: SPAP_RS04945
  • pan gene symbol?: pyrK
  • synonym:
  • product: dihydroorotate dehydrogenase electron transfer subunit

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_RS04945 [old locus tag: SPAP_0995 ]
  • symbol: SPAP_RS04945
  • product: dihydroorotate dehydrogenase electron transfer subunit
  • replicon: chromosome
  • strand: +
  • coordinates: 943252..944052
  • length: 801
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014494 (943252..944052) NCBI
  • BioCyc: SPAP_RS04945 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0851 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGAATCTCACATGTAAGAAGCGTTTGGGTGTCATTCGGTTGGAAACCATGAAGGTGGTT
    GCACAAGAGGAAATCGCGCCAGCAATCTTTGAATTAGTCCTAGAAGGAGAAATGGTTGAA
    GCCATGCGAGCAGGCCAATTTCTTCATCTGCGTGTACCAGACGATGCCCATCTCTTACGT
    CGTCCTATTTCAATTTCGTCTATTGACAAGGCAAACAAGCAGTGTCACCTCATTTATCGG
    ATTGAGGGAGCTGGGACTGCAATTTTTTCAACCTTAAGTCAGGGAGACACTCTTGATGTG
    ATGGGGCCTCAGGGAAATGGTTTTGACTTGTCTGACCTTGATGAGCAGAATCAGGTTCTC
    CTTGTTGGTGGTGGGATTGGTGTTCCACCCTTGCTTGAGGTGGCCAAGGAATTGCATGAA
    CGTGGAGTGAAAGTAGTGACAGTCCTCGGTTTTGCTAATAAGGATGCTGTTATTTTGAAA
    ACGGAATTGGCTCAGTATGGTCAGGTCTTTGTAACGACAGATGATGGTTCTTATGGCATC
    AAGGGAAATGTTTCCGTTGTTATCAATGATTTAGATAGTCAGTTTGATGCTGTTTACTCG
    TGTGGGGCTCCAGGAATGATGAAGTATATCAATCAAACCTTTGATGATCACCCAAGAGCC
    TATTTATCTCTGGAATCTCGTATGGCTTGTGGGATGGGAGCTTGCTATGCCTGTGTTCTA
    AAAGTACCAGAAAGCGAGACGGTCAGCCAACGCGTCTGTGAAGATGGTCCTGTTTTCCGC
    ACAGGAACAGTTGTATTATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    801

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_RS04945 [old locus tag: SPAP_0995 ]
  • symbol: SPAP_RS04945
  • description: dihydroorotate dehydrogenase electron transfer subunit
  • length: 266
  • theoretical pI: 4.76852
  • theoretical MW: 28883.1
  • GRAVY: 0.0759398

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Central intermediary metabolism Sulfur metabolism sulfite reductase, subunit B (TIGR02911; EC 1.8.-.-; HMM-score: 75.9)
    and 3 more
    Metabolism Energy metabolism Other phenylacetate-CoA oxygenase/reductase, PaaK subunit (TIGR02160; HMM-score: 38.9)
    Metabolism Energy metabolism Other benzoyl-CoA oxygenase/reductase, BoxA protein (TIGR03224; EC 1.14.12.21; HMM-score: 12.3)
    sulfite reductase [NADPH] flavoprotein, alpha-component (TIGR01931; EC 1.8.1.2; HMM-score: 9.8)
  • TheSEED: see SPAP_0995
  • PFAM:
    Fer2 (CL0486) DHODB_Fe-S_bind; Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B (PF10418; HMM-score: 57.1)
    and 4 more
    NAD_Ferredoxin (CL0091) NAD_binding_1; Oxidoreductase NAD-binding domain (PF00175; HMM-score: 27.3)
    FAD_Lum_binding (CL0076) FAD_binding_6; Oxidoreductase FAD-binding domain (PF00970; HMM-score: 25)
    TKC_like (CL0591) Transketolase_C; Transketolase, C-terminal domain (PF02780; HMM-score: 23.2)
    NAD_Ferredoxin (CL0091) NAD_binding_6; Ferric reductase NAD binding domain (PF08030; HMM-score: 20.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9979
    • Cytoplasmic Membrane Score: 0.0013
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0007
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001992
    • TAT(Tat/SPI): 0.000138
    • LIPO(Sec/SPII): 0.000252
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001054489 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNLTCKKRLGVIRLETMKVVAQEEIAPAIFELVLEGEMVEAMRAGQFLHLRVPDDAHLLRRPISISSIDKANKQCHLIYRIEGAGTAIFSTLSQGDTLDVMGPQGNGFDLSDLDEQNQVLLVGGGIGVPPLLEVAKELHERGVKVVTVLGFANKDAVILKTELAQYGQVFVTTDDGSYGIKGNVSVVINDLDSQFDAVYSCGAPGMMKYINQTFDDHPRAYLSLESRMACGMGACYACVLKVPESETVSQRVCEDGPVFRTGTVVL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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