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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 22-FEB-2023

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_RS05905 [old locus tag: SPAP_1194 ]
  • pan locus tag?: PNEUPAN002028000
  • symbol: sipA
  • pan gene symbol?: sipA
  • synonym:
  • product: PI-2 pilus system signal peptidase SipA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_RS05905 [old locus tag: SPAP_1194 ]
  • symbol: sipA
  • product: PI-2 pilus system signal peptidase SipA
  • replicon: chromosome
  • strand: -
  • coordinates: 1129020..1129571
  • length: 552
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014494 (1129020..1129571) NCBI
  • BioCyc: SPAP_RS05905 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    ATGCTGCTTAAAAAGAAACATAAGAAACCAGTAACACAAGTCAATCGGGATAAGTCTCCG
    CCGAGTGTCTGGGGAGATATCCTTTACTTAGTCAGTAAACTTCTGATGGTTGGATTTGTA
    CTAGCCATCCTTTACTTTTTCGTCTTTGGATTATTAAGATACAATGACGATGGCATGAAG
    CCCGCCTTAAAAGATGGCGACTTGGTCGTCTATTATAGGTTGGATAAACGCTATTCGATT
    GGTGATTTGCTAGTCTATAGTTATAAAGGTAAGGAAAGAGTGGCGCGTGTCATAGCAACC
    GAAGGAAGTACAATCGATATAAACGAAAATGGTCTCATCATCAACGGTTCTCCTCAACAA
    GAGCAAGATATCTACAAAGAAACGCTGCTCTATAAGGAAGGGGCAACCTTCCCGATGAAA
    GTCCCAGCAGGACAACTTTTTGTCCTCGGGGACAATCGAACAACGGCTGTAGACAGTCGT
    GCTTTTGGAACCATCCCTATACAGGATACTCAAGGCAAAGTTGTAACAGTCATTAGAAGA
    CGAGGCTTTTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    552

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_RS05905 [old locus tag: SPAP_1194 ]
  • symbol: SipA
  • description: PI-2 pilus system signal peptidase SipA
  • length: 183
  • theoretical pI: 10.0374
  • theoretical MW: 20667.9
  • GRAVY: -0.128962

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein fate Protein and peptide secretion and trafficking signal peptidase I (TIGR02227; EC 3.4.21.89; HMM-score: 106.8)
    and 4 more
    Cellular processes Cellular processes Detoxification nickel-type superoxide dismutase maturation protease (TIGR02754; EC 3.4.21.-; HMM-score: 35)
    Genetic information processing Protein fate Protein modification and repair nickel-type superoxide dismutase maturation protease (TIGR02754; EC 3.4.21.-; HMM-score: 35)
    conjugative transfer signal peptidase TraF (TIGR02771; HMM-score: 22.9)
    signal peptidase I (TIGR02228; EC 3.4.21.89; HMM-score: 15.5)
  • TheSEED: see SPAP_1194
  • PFAM:
    Peptidase_SF (CL0299) Peptidase_S26; Signal peptidase, peptidase S26 (PF10502; HMM-score: 75.2)
    and 1 more
    Peptidase_S24; Peptidase S24-like (PF00717; HMM-score: 16.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helix: 1
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0014
    • Cytoplasmic Membrane Score: 0.9947
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0037
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.000617
    • TAT(Tat/SPI): 0.000157
    • LIPO(Sec/SPII): 0.004919
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000924778 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MLLKKKHKKPVTQVNRDKSPPSVWGDILYLVSKLLMVGFVLAILYFFVFGLLRYNDDGMKPALKDGDLVVYYRLDKRYSIGDLLVYSYKGKERVARVIATEGSTIDINENGLIINGSPQQEQDIYKETLLYKEGATFPMKVPAGQLFVLGDNRTTAVDSRAFGTIPIQDTQGKVVTVIRRRGF

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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