PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 22-FEB-2023

⊟Summary

• organism: Streptococcus pneumoniae AP200
• locus tag: SPAP_RS08775 [old locus tag: SPAP_1770 ]
• pan locus tag^?: PNEUPAN003257000
• symbol: SPAP_RS08775
• pan gene symbol^?: sdpR
• synonym:
• product: ArsR/SmtB family transcription factor

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPAP_RS08775 [old locus tag: SPAP_1770 ]
• symbol: SPAP_RS08775
• product: ArsR/SmtB family transcription factor
• replicon: chromosome
• strand: +
• coordinates: 1670102..1670779
• length: 678
• essential: unknown

⊟Accession numbers

• Location: NC_014494 (1670102..1670779) NCBI
• BioCyc: SPAP_RS08775 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V:

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
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  661
  
  ATGGAACCAGATATTTTCATCATCACAAAACTCTTATCAGACCCTTCTCGGATGCACATT
  TTAGATATTCTAATGGATGGAAAAGCTCACACGGTTAACGAAATTGCCAGCTTTACCAAA
  ATCAAGCAACATACTGTCAGCTATCACCTCAAATTACTTACCGAAGCGCAGGTAACCACT
  CTACAAACCTATGGACGTTTTCATTATTATTCTTTAAAAAGTGCTGCCATTGCAGAAATG
  CTGGAATTTCTCAGCTTCTACTCTCCTCAGCGTGATGTCAAAAGTTATAAACAACACATT
  CACAAAAAGGAATTAAAAGTCGCTCGCACCTGCTATGACCATATTGCTGGTGAGCTTGGC
  ATTTCCATTACCAATTATCTCTTGCAAGAAAATCTCCTCAGCGAATCAGAAAAAGACTTC
  CAACTCACTGAAGCTGGGAAGTCTTATTTCCAAAGAAAATTACACATTGATACGGATGAA
  TTGAAAAAGAAAAAACGGAAATTTTGCCCTAAATGTTTGGATTGGAGCGAACGTAAAAAT
  CATGTCGGCGGAGCTCTCGGCAATGCTCTTTTAGAATTTTTCAGTGAAAAACAATTGGTC
  ATCCCTGCACAAACGCCACGTTCACTTACCATTACAGAGAAGGGCAAAGAATTCCTCGAA
  AAGGAATGGGGGATTTAA
  60
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  678
  

⊟Protein

⊟General

• locus tag: SPAP_RS08775 [old locus tag: SPAP_1770 ]
• symbol: SPAP_RS08775
• description: ArsR/SmtB family transcription factor
• length: 225
• theoretical pI: 8.99572
• theoretical MW: 26068.9
• GRAVY: -0.437333

⊟Function

• TIGRFAM:
  Signal transduction Regulatory functions DNA interactions CRISPR locus-related DNA-binding protein (TIGR01884; HMM-score: 12.3)
• TheSEED: see SPAP_1770
• PFAM:
  HTH (CL0123) HTH_20; Helix-turn-helix domain (PF12840; HMM-score: 42)
  and 12 more
  HTH_5; Bacterial regulatory protein, arsR family (PF01022; HMM-score: 33.4)
  HTH_45; Winged helix-turn-helix (PF14947; HMM-score: 23.4)
  MarR_2; MarR family (PF12802; HMM-score: 22)
  HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 21.1)
  MarR; MarR family (PF01047; HMM-score: 18.1)
  no clan defined TniQ; TniQ (PF06527; HMM-score: 17.3)
  HTH (CL0123) GerE; Bacterial regulatory proteins, luxR family (PF00196; HMM-score: 16.3)
  6_Hairpin (CL0059) LANC_like; Lanthionine synthetase C-like protein (PF05147; HMM-score: 15.2)
  HTH (CL0123) HTH_34; Winged helix DNA-binding domain (PF13601; HMM-score: 14.7)
  P-loop_NTPase (CL0023) UvrD_C; UvrD-like helicase C-terminal domain (PF13361; HMM-score: 14.3)
  HTH (CL0123) DUF2513; Hypothetical protein (DUF2513) (PF10711; HMM-score: 13.9)
  RuvB_C; RuvB C-terminal winged helix domain (PF05491; HMM-score: 12.7)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9847
  • Cytoplasmic Membrane Score: 0.0097
  • Cell wall & surface Score: 0.0003
  • Extracellular Score: 0.0052
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.006097
  • TAT(Tat/SPI): 0.000132
  • LIPO(Sec/SPII): 0.000686
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000433070 NCBI
• UniProt:

⊟Protein sequence

• MEPDIFIITKLLSDPSRMHILDILMDGKAHTVNEIASFTKIKQHTVSYHLKLLTEAQVTTLQTYGRFHYYSLKSAAIAEMLEFLSFYSPQRDVKSYKQHIHKKELKVARTCYDHIAGELGISITNYLLQENLLSESEKDFQLTEAGKSYFQRKLHIDTDELKKKKRKFCPKCLDWSERKNHVGGALGNALLEFFSEKQLVIPAQTPRSLTITEKGKEFLEKEWGI

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V:

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications