PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 07-FEB-2021

⊟Summary

• organism: Streptococcus pneumoniae AP200
• locus tag: SPAP_RS09410 [old locus tag: SPAP_1897 ]
• pan locus tag^?: PNEUPAN003397000
• symbol: SPAP_RS09410
• pan gene symbol^?: msmR
• synonym:
• product: AraC family transcriptional regulator

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPAP_RS09410 [old locus tag: SPAP_1897 ]
• symbol: SPAP_RS09410
• product: AraC family transcriptional regulator
• replicon: chromosome
• strand: +
• coordinates: 1789208..1790068
• length: 861
• essential: unknown

⊟Accession numbers

• Location: NC_014494 (1789208..1790068) NCBI
• BioCyc: SPAP_RS09410 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_1679 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  
  ATGCTAGTTTTTTCAGAATACCAGACTGGAACAATTGACCTTGCCCTAAGCTTTTATGGA
  TATGAGGAATGCACACCTAATTACTCTTTTGGTCCAGCCATTCGTGATACATACGTCCTA
  CATTACATTACTAAAGGACAAGGAAAATTTCATTACAAGGGTAAAATTGTTGATTTAAAA
  GAAGGAGATTTCTTTCTATTAAAACCAGAGGAACTAACCTTTTATCAAGCAGATAGTAAA
  GAACCTTGGGCCTACTACTGGTTAGGAATCACTGGAGGGAAATCCCCTGATTATTTTGCT
  CTTTCTCAAATTTCTGATCAATCCTATCTCATCCAATCTGAAACTTGTCATACCCAGACT
  ACTGCAAAACTCATCTCAGACATTGTCCGCTTCGCTCAGATTACAAAATCAAGTGAATTA
  TCTCAACTCCATATCATGGGACAACTTCATGAACTGATGTTTCATCTGGGAACTATTGCT
  CCCAATCAGAAAAAAAAGAATATTTCATCAACCCACCAACTCTATCTTGAATGCAAACGA
  TTAATTGATAGCCACTATCCTCAATCACTTACAATTCAAGATTTAGCAAAAGAACTATCC
  GTTCACAGAAGCTACTTATCAAGCGTATTCAAAGAATTTAATACCTTATCACCCAAAGAA
  TACCTACTCTACATTCGAATGCACCGAGCTAGACAACTTCTCGAAAATACCCAAGAGTCC
  ATCAAGGTAATTGCATACTCGGTAGGTTTTTCAGATCCACTCCATTTTTCGAAAGCTTAT
  AAACAATACTTTAATCAGACTCCAAGTCATACAAGAAAAGAATACTCTCAATACCAACTA
  GTGAGAAAGGCAACATTATGA
  60
  120
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  840
  861
  

⊟Protein

⊟General

• locus tag: SPAP_RS09410 [old locus tag: SPAP_1897 ]
• symbol: SPAP_RS09410
• description: AraC family transcriptional regulator
• length: 286
• theoretical pI: 8.62517
• theoretical MW: 33248.6
• GRAVY: -0.422378

⊟Function

• TIGRFAM:
  4-hydroxyphenylacetate catabolism regulatory protein HpaA (TIGR02297; HMM-score: 62.4)
  and 4 more
  YSIRK-targeted surface antigen transcriptional regulator (TIGR04094; HMM-score: 47.1)
  Genetic information processing Mobile and extrachromosomal element functions Other addiction module antidote protein, HigA family (TIGR02607; HMM-score: 13.3)
  Signal transduction Regulatory functions DNA interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 13.3)
  Signal transduction Regulatory functions Protein interactions addiction module antidote protein, HigA family (TIGR02607; HMM-score: 13.3)
• TheSEED: see SPAP_1897
• PFAM:
  Cupin (CL0029) AraC_binding; AraC-like ligand binding domain (PF02311; HMM-score: 102.4)
  HTH (CL0123) HTH_18; Helix-turn-helix domain (PF12833; HMM-score: 84)
  and 6 more
  HTH_AraC; Bacterial regulatory helix-turn-helix proteins, AraC family (PF00165; HMM-score: 65)
  Cupin (CL0029) Cupin_2; Cupin domain (PF07883; HMM-score: 16.9)
  HTH (CL0123) HTH_3; Helix-turn-helix (PF01381; HMM-score: 14.5)
  MarR; MarR family (PF01047; HMM-score: 13)
  Ferritin (CL0044) DUF5623; Domain of unknown function (DUF5623) (PF18536; HMM-score: 12.6)
  Cupin (CL0029) AraC_binding_2; AraC-binding-like domain (PF14525; HMM-score: 11.6)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.024881
  • TAT(Tat/SPI): 0.000599
  • LIPO(Sec/SPII): 0.005051
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000959964 NCBI
• UniProt:

⊟Protein sequence

• MLVFSEYQTGTIDLALSFYGYEECTPNYSFGPAIRDTYVLHYITKGQGKFHYKGKIVDLKEGDFFLLKPEELTFYQADSKEPWAYYWLGITGGKSPDYFALSQISDQSYLIQSETCHTQTTAKLISDIVRFAQITKSSELSQLHIMGQLHELMFHLGTIAPNQKKKNISSTHQLYLECKRLIDSHYPQSLTIQDLAKELSVHRSYLSSVFKEFNTLSPKEYLLYIRMHRARQLLENTQESIKVIAYSVGFSDPLHFSKAYKQYFNQTPSHTRKEYSQYQLVRKATL

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• data available for TIGR4

⊟Expression data

• PneumoExpress for strain D39V: SPV_1679 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications