From PneumoWiki
Jump to navigation Jump to search
PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 07-FEB-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_RS10770 [old locus tag: SPAP_2177 ]
  • pan locus tag?: PNEUPAN003678000
  • symbol: SPAP_RS10770
  • pan gene symbol?: tktC
  • synonym:
  • product: transketolase family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_RS10770 [old locus tag: SPAP_2177 ]
  • symbol: SPAP_RS10770
  • product: transketolase family protein
  • replicon: chromosome
  • strand: -
  • coordinates: 2014835..2015767
  • length: 933
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014494 (2014835..2015767) NCBI
  • BioCyc: SPAP_RS10770 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_1957 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGATGAGAAGCACGAAAGAATTACGGCATGTATATAGAGACTTCCTTTTAGAGGCTAAT
    CAAAGTTATTCTGATATAGTAGTCTTAGAAGCCGATTTGTCAAGTTCGATGGCTACTAAT
    AATCTTGAAAAGGATTTTGGAGACCGTTATGTGAATGTTGGGATTATGGAAGCAGAAATG
    GTCGGCCTTGCAGCAGGCTTGTCTATTCAGGGGTTTAGACCTTATCTTCATACATTTGGT
    CCTTTTGCTTCACGAAGAGTATTTGATCAATTATTTATTTCTCTTGGATACGCACAATTG
    GATGCCACTGTGATTGGATCAGATGCAGGAGTAACGGCAGAGATGAATGGTGGAACACAT
    ATGCCATTTGAAGAAATTGGATTGTTACGTTTAATTCCTAAATCGATCATTTTTGAAGCA
    ACTGATGATATCCAATTTCGTGAAATATTGAACCAGACATTAGACTTAAAAGGACTAAAA
    TATATTCGAACAATTAGAAAAGCTCCAGTTCCTGTGTATCAAGGTGGAGAAGATTTTTCT
    AAAGGCTACATTGAGTTAAGGCATGGTGAAGATCTTGTAATCGTTGCTTCTGGTATAATG
    GTTGCTCCAAGTATTCGAGTTGCAGATGAACTGTCTAAATTAGGTTATTCAGTAAGTGTG
    ATAGATTTATTTAGAATCAAACCGATACCAGAACAGATAAAAACAATGTTAAGTGGAAAA
    ACTATATTTACTGTAGAAAACCACAATCAGATAGGTGGAATTGGCAGTTCTTTATGTGAA
    TTATTCTCTGATGATGGAATGACAAAAATTCATCGGATGGGTGTTCAAGAAAGATTCGGT
    CAAGTAGGGAAAATGGATTATCTTCTTAATGAGTATGGTTTGAGTGAATCGAATATAAAA
    GAGAAGGTTCTAGAAATTTATAATGCAAGATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    933

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_RS10770 [old locus tag: SPAP_2177 ]
  • symbol: SPAP_RS10770
  • description: transketolase family protein
  • length: 310
  • theoretical pI: 5.09439
  • theoretical MW: 34609.5
  • GRAVY: -0.0580645

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 121.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 121.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridoxine 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 121.2)
    and 2 more
    Metabolism Energy metabolism Pentose phosphate pathway transketolase (TIGR00232; EC 2.2.1.1; HMM-score: 49.4)
    2-oxoacid:acceptor oxidoreductase, alpha subunit (TIGR03710; HMM-score: 13.6)
  • TheSEED: see SPAP_2177
  • PFAM:
    TKC_like (CL0591) Transketolase_C; Transketolase, C-terminal domain (PF02780; HMM-score: 71.9)
    THDP-binding (CL0254) Transket_pyr; Transketolase, pyrimidine binding domain (PF02779; HMM-score: 71.1)
    and 1 more
    TKC_like (CL0591) PFOR_II; Pyruvate:ferredoxin oxidoreductase core domain II (PF17147; HMM-score: 17.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006882
    • TAT(Tat/SPI): 0.001576
    • LIPO(Sec/SPII): 0.00056
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000986405 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MMRSTKELRHVYRDFLLEANQSYSDIVVLEADLSSSMATNNLEKDFGDRYVNVGIMEAEMVGLAAGLSIQGFRPYLHTFGPFASRRVFDQLFISLGYAQLDATVIGSDAGVTAEMNGGTHMPFEEIGLLRLIPKSIIFEATDDIQFREILNQTLDLKGLKYIRTIRKAPVPVYQGGEDFSKGYIELRHGEDLVIVASGIMVAPSIRVADELSKLGYSVSVIDLFRIKPIPEQIKTMLSGKTIFTVENHNQIGGIGSSLCELFSDDGMTKIHRMGVQERFGQVGKMDYLLNEYGLSESNIKEKVLEIYNAR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Retrieved from "http://pneumowiki.med.uni-greifswald.de/index.php?title=SPAP_RS10770&oldid=42088"