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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 22-FEB-2023

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae AP200
  • locus tag: SPAP_RS11465 [old locus tag: SPAP_0026 ]
  • pan locus tag?: PNEUPAN000389000
  • symbol: SPAP_RS11465
  • pan gene symbol?: —
  • synonym:
  • product: HIRAN domain-containing protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPAP_RS11465 [old locus tag: SPAP_0026 ]
  • symbol: SPAP_RS11465
  • product: HIRAN domain-containing protein
  • replicon: chromosome
  • strand: -
  • coordinates: 24787..25587
  • length: 801
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_014494 (24787..25587) NCBI
  • BioCyc: SPAP_RS11465 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGGGATGGGTTAAAAATCCAAAGAAAGCCATGTATAACAAAGTCTATCATAAGACAACC
    TTTGGACTTTCAGATTTGTTTAAATCATCTAAAAAGCGAAAAAAGAAAGTAGTCAACAAC
    AAACAGCAATCTATTCTTGCCTCGAACGGCAAAAAGCAACACACGTCAAAAGAATATAAA
    GAAGCTGGACTTGTCTTTATGGTTTTAGGTGCTATATTCCTATTTTTATTTCTACCTCTC
    GGCTTCTTCTTGTTTATTACTGGTTTTATAACTTACATTATTGGTCTTTTAACTGCAAAT
    CGAGAGAAAAAGAAGAAAGTTGAAAATTACAGTCCACAGATTGATACAACTGTTTTCCGA
    GATGATTTCTTATTAATGGGAACAAATTATCATCAAGAAGAAGCTGAGATTGCAGCTGAT
    TTTCTTTCCAAGGGTGTCCATTATTTTGGGAAAGATAATAAGAGTTTGAAATCTTATATG
    CTTGAAACATATAAACCAGTTTATAAATACAATAAATTAAAAACAGTAGATGTTCATCTA
    TTGCCGGAGCCATCAAATCCTCATGATAAAAATGCTGTCAAGGTTTTAGTGAATAATATC
    TTTGTCGGATACTTACCAGCTATGATTGCAACACAAGTTTCATCCTACATTTCTAATCCA
    AATTACAGATATGATGCAATCCTTACAGGTAGAGGAGGACCATATAAAACTCTCAATATC
    GAAACTGAGAGAGTCGTTTCTCGTAAAAGTGACTTAACTTACTATTTAGATTTAACAGTA
    TGGCGTCTCGCTAAAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    801

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPAP_RS11465 [old locus tag: SPAP_0026 ]
  • symbol: SPAP_RS11465
  • description: HIRAN domain-containing protein
  • length: 266
  • theoretical pI: 10.2903
  • theoretical MW: 30632.4
  • GRAVY: -0.343985

⊟Function[edit | edit source]

  • TIGRFAM:
    cxxc_20_cxxc protein (TIGR04104; HMM-score: 12.6)
  • TheSEED: see SPAP_0026
  • PFAM:
    no clan defined HIRAN; HIRAN domain (PF08797; HMM-score: 34.3)
    and 9 more
    YhhN; YhhN family (PF07947; HMM-score: 14.5)
    DUF2207; Predicted membrane protein (DUF2207) (PF09972; HMM-score: 14.3)
    Transporter (CL0375) Claudin_2; PMP-22/EMP/MP20/Claudin tight junction (PF13903; HMM-score: 14.2)
    no clan defined OAD_gamma; Oxaloacetate decarboxylase, gamma chain (PF04277; HMM-score: 13.5)
    TMEM72; Transmembrane protein family 72 (PF16054; HMM-score: 12.4)
    CrgA; Cell division protein CrgA (PF06781; HMM-score: 12.3)
    CNDH2_M; Condensin II complex subunit CAP-H2 or CNDH2, mid domain (PF16869; HMM-score: 11.6)
    Prominin; Prominin (PF05478; HMM-score: 9.2)
    DsbG_N; Disulfide isomerase DsbG N-terminal (PF18257; HMM-score: 9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.32
    • Cytoplasmic Membrane Score: 9.55
    • Cellwall Score: 0.12
    • Extracellular Score: 0.01
    • Internal Helices: 2
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0004
    • Cytoplasmic Membrane Score: 0.8655
    • Cell wall & surface Score: 0.0003
    • Extracellular Score: 0.1338
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.011183
    • TAT(Tat/SPI): 0.000636
    • LIPO(Sec/SPII): 0.002483
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000539947 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MGWVKNPKKAMYNKVYHKTTFGLSDLFKSSKKRKKKVVNNKQQSILASNGKKQHTSKEYKEAGLVFMVLGAIFLFLFLPLGFFLFITGFITYIIGLLTANREKKKKVENYSPQIDTTVFRDDFLLMGTNYHQEEAEIAADFLSKGVHYFGKDNKSLKSYMLETYKPVYKYNKLKTVDVHLLPEPSNPHDKNAVKVLVNNIFVGYLPAMIATQVSSYISNPNYRYDAILTGRGGPYKTLNIETERVVSRKSDLTYYLDLTVWRLAKK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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