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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae CGSP14
  • locus tag: SPCG_0413 [new locus tag: SPCG_RS02150 ]
  • pan locus tag?: PNEUPAN001284000
  • symbol: phaB
  • pan gene symbol?: fabM
  • synonym:
  • product: enoyl-CoA hydratase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPCG_0413 [new locus tag: SPCG_RS02150 ]
  • symbol: phaB
  • product: enoyl-CoA hydratase
  • replicon: chromosome
  • strand: +
  • coordinates: 409579..410349
  • length: 771
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGGAACACATTATTTATCAGCTTGAAGAGGACTTGGCAATCCTTACCTTGAACCGTCCT
    GAGGTCGCAAATGGTTTTCATATTCCCATGTGTGAGGAGATTTTAGAAGCTCTGACTTTG
    GCAGAAGAAAATCCAGCTGTGCATTTTATCTTAATCAATGCCAATGGGAAGGTCTTCTCA
    GTTGGGGGAGATTTGGTAGAGATGAAGCGGGCAGTGGATGAGGATGATATTCCATCATTG
    ACAAAAATCGCAGAGTTGGTCAATACGATTTCTTATAAAATCAAGCAAATAGCCAAACCT
    GTTTTAATGGAAGTTGACGGTGCTGTTGCAGGTGCCGCAGCGAATATGGCTGTTGCGGCA
    GATTTCTGTTTGGCGACGGATAAGGCTAAGTTTATCCAAGCCTTTGTTGGTGTTGGTTTG
    GCTCCAGATGCAGGGGGAATTCATCTCTTGAGCCGCAGTATCGGTGTGACGCGTGCTGCT
    CAATTAGCTATGACAGGAGAGGCTTTAACGGCAGAAAAAGCCCTAGAATGGGGGTTGGTT
    TACCGCGTTTCTGAAGCTGAAAAACTTGAAAAGACGAGAGAACAGCTTCTTAAAAAATTA
    AGACGTGCTTCAAGTAATTCCTATGCTGCCATTAAGAAGTTGGTTTGGGAGAGCCAATTT
    AAAGACTGGCAGGGTTACGCTACTTTAGAACTGAACCTACAGAAATCCTTAGCTCAAACA
    GAGGATTTCAAAGAAGGAGTGCCGAGCTCATTCGGAGAGAAGAAGACCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    771

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPCG_0413 [new locus tag: SPCG_RS02150 ]
  • symbol: PhaB
  • description: enoyl-CoA hydratase
  • length: 256
  • theoretical pI: 4.9414
  • theoretical MW: 27977
  • GRAVY: -0.003125

⊟Function[edit | edit source]

  • TIGRFAM:
    phenylacetate degradation probable enoyl-CoA hydratase PaaB (TIGR02280; EC 4.2.1.17; HMM-score: 181.2)
    and 8 more
    2-ketocyclohexanecarboxyl-CoA hydrolase (TIGR03210; EC 3.7.-.-; HMM-score: 81.7)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone naphthoate synthase (TIGR01929; EC 4.1.3.36; HMM-score: 81.4)
    Metabolism Fatty acid and phospholipid metabolism Degradation fatty oxidation complex, alpha subunit FadB (TIGR02437; EC 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8; HMM-score: 72.1)
    fatty acid oxidation complex, alpha subunit, mitochondrial (TIGR02441; EC 1.1.1.35,4.2.1.17; HMM-score: 50.9)
    Metabolism Fatty acid and phospholipid metabolism Degradation fatty oxidation complex, alpha subunit FadJ (TIGR02440; EC 1.1.1.35,4.2.1.17,5.1.2.3; HMM-score: 47.2)
    6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase (TIGR03200; EC 3.-.-.-; HMM-score: 47)
    cyclohexa-1,5-dienecarbonyl-CoA hydratase (TIGR03189; EC 4.2.1.100; HMM-score: 42.4)
    benzoyl-CoA-dihydrodiol lyase (TIGR03222; EC 4.1.2.44; HMM-score: 21.6)
  • TheSEED  :
    • Trans-2,cis-3-Decenoyl-ACP isomerase
    Fatty Acids, Lipids, and Isoprenoids Fatty acids Fatty Acid Biosynthesis FASII  Trans-2,cis-3-Decenoyl-ACP isomerase
  • PFAM:
    ClpP_crotonase (CL0127) ECH_1; Enoyl-CoA hydratase/isomerase (PF00378; HMM-score: 154)
    and 2 more
    ECH_2; Enoyl-CoA hydratase/isomerase (PF16113; HMM-score: 116.5)
    Peptidase_S49; Peptidase family S49 (PF01343; HMM-score: 11.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002776
    • TAT(Tat/SPI): 0.000107
    • LIPO(Sec/SPII): 0.000199
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MEHIIYQLEEDLAILTLNRPEVANGFHIPMCEEILEALTLAEENPAVHFILINANGKVFSVGGDLVEMKRAVDEDDIPSLTKIAELVNTISYKIKQIAKPVLMEVDGAVAGAAANMAVAADFCLATDKAKFIQAFVGVGLAPDAGGIHLLSRSIGVTRAAQLAMTGEALTAEKALEWGLVYRVSEAEKLEKTREQLLKKLRRASSNSYAAIKKLVWESQFKDWQGYATLELNLQKSLAQTEDFKEGVPSSFGEKKT

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: FabT* (repression) regulon
    FabT*(TF)important in Fatty acid biosynthesis; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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