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serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae CGSP14
  • locus tag: SPCG_0689 [new locus tag: SPCG_RS03605 ]
  • pan locus tag?: PNEUPAN001677000
  • symbol: SPCG_0689
  • pan gene symbol?: mta
  • synonym:
  • product: transcriptional regulator, MerR family

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPCG_0689 [new locus tag: SPCG_RS03605 ]
  • symbol: SPCG_0689
  • product: transcriptional regulator, MerR family
  • replicon: chromosome
  • strand: +
  • coordinates: 688412..689152
  • length: 741
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGTACCATATAAAAGAAGCTGCGCAGCTTTCAGGTGTCTCTGTCAAGACCCTGCATCAC
    TATGACAAGATAGGACTCTTGGTCCCCTTAAAGTCGGAAAACGGCTATCGAACCTACAGT
    CAAGAGGATTTGGAACGCCTTCAGGTCATTCTTTACTACAAATATCTAGGCTTTTCTTTA
    GAGAAAATAGCAGAGCTGTTAAAGGAAGAAAGGACAGATTTATTGCCCCATTTGACTAGG
    CAGTTGGACTATCTAACTCGCGAAAGGCAACATCTGGATACCTTGATTTCCACCTTGCAA
    AAAACTATTCAAGAACAAAAAGGAGAAAGAAAAATGACCATTGAGGAAAAATTCACGGGA
    TTTAGCTATCAAGACAATCAAAAATACCACCAAGAAGCGGTAGAGAAATATGGTCAAGAA
    GTCATGGGACAAGCGCTCGAACGCCAAAAAGGTCACGAAGACGAGGCTACGGCCGCCTTT
    AACCAAGTCTTTCAAACTTTGGCACAAAATCTTCAAGTTGGTTTACCTGCAACAGCAACC
    GAAAACCAGGAGCAAGCAGCCAAGCTCTTGCAAGCCATTCGCACTTATGGATTTGACTGC
    TCTATTGAGGTATTCGGTCATATCGGTAAAGGTTACGTCTACAACCCAGAGTTTAAGGAA
    AACATTGACAAGTTTGGTTCTGAAACAGCCCAGTACACGTCAGATGCCATTGCGGCTTAC
    GTTCAGACAAATGCAGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    741

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPCG_0689 [new locus tag: SPCG_RS03605 ]
  • symbol: SPCG_0689
  • description: transcriptional regulator, MerR family
  • length: 246
  • theoretical pI: 5.39417
  • theoretical MW: 28303.5
  • GRAVY: -0.642276

⊟Function[edit | edit source]

  • TIGRFAM:
    Signal transduction Regulatory functions DNA interactions Cu(I)-responsive transcriptional regulator (TIGR02044; HMM-score: 57.5)
    Signal transduction Regulatory functions DNA interactions Zn(II)-responsive transcriptional regulator (TIGR02043; HMM-score: 54.5)
    Cellular processes Cellular processes Detoxification Hg(II)-responsive transcriptional regulator (TIGR02051; HMM-score: 48.7)
    Signal transduction Regulatory functions DNA interactions Hg(II)-responsive transcriptional regulator (TIGR02051; HMM-score: 48.7)
    and 6 more
    Signal transduction Regulatory functions DNA interactions Cd(II)/Pb(II)-responsive transcriptional regulator (TIGR02047; HMM-score: 40.4)
    Cellular processes Cellular processes Detoxification redox-sensitive transcriptional activator SoxR (TIGR01950; HMM-score: 30.4)
    Signal transduction Regulatory functions DNA interactions redox-sensitive transcriptional activator SoxR (TIGR01950; HMM-score: 30.4)
    Cellular processes Cellular processes Detoxification mercuric resistence transcriptional repressor protein MerD (TIGR02054; HMM-score: 19.3)
    HAD phosphatase, family IIIC (TIGR01681; HMM-score: 14.6)
    4-nitrotryptophan synthase (TIGR04458; EC 1.-.-.-; HMM-score: 11.8)
  • TheSEED  :
    • Regulator of the multidrug efflux pump pmrA
  • PFAM:
    no clan defined TipAS; TipAS antibiotic-recognition domain (PF07739; HMM-score: 74.3)
    HTH (CL0123) MerR_1; MerR HTH family regulatory protein (PF13411; HMM-score: 68)
    and 10 more
    MerR; MerR family regulatory protein (PF00376; HMM-score: 54.1)
    MerR-DNA-bind; MerR, DNA binding (PF09278; HMM-score: 36.9)
    HTH_8; Bacterial regulatory protein, Fis family (PF02954; HMM-score: 19.6)
    HTH_17; Helix-turn-helix domain (PF12728; HMM-score: 18.4)
    no clan defined Enkurin; Calmodulin-binding (PF13864; HMM-score: 15.9)
    HTH (CL0123) HTH_23; Homeodomain-like domain (PF13384; HMM-score: 13.1)
    Sigma70_r4_2; Sigma-70, region 4 (PF08281; HMM-score: 12.9)
    DNA_primase_lrg (CL0242) DNA_primase_lrg; Eukaryotic and archaeal DNA primase, large subunit (PF04104; HMM-score: 12.6)
    PDDEXK (CL0236) VRR_NUC; VRR-NUC domain (PF08774; HMM-score: 12.1)
    no clan defined STAT_int; STAT protein, protein interaction domain (PF02865; HMM-score: 10.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9878
    • Cytoplasmic Membrane Score: 0.0044
    • Cell wall & surface Score: 0.0015
    • Extracellular Score: 0.0063
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001448
    • TAT(Tat/SPI): 0.000139
    • LIPO(Sec/SPII): 0.000288
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACB89941 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MYHIKEAAQLSGVSVKTLHHYDKIGLLVPLKSENGYRTYSQEDLERLQVILYYKYLGFSLEKIAELLKEERTDLLPHLTRQLDYLTRERQHLDTLISTLQKTIQEQKGERKMTIEEKFTGFSYQDNQKYHQEAVEKYGQEVMGQALERQKGHEDEATAAFNQVFQTLAQNLQVGLPATATENQEQAAKLLQAIRTYGFDCSIEVFGHIGKGYVYNPEFKENIDKFGSETAQYTSDAIAAYVQTNAE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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