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serotype 4
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serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
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serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
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ASP0581
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ATCC 700669
serotype 23F
BM6001
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serotype 14
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HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae CGSP14
  • locus tag: SPCG_0928 [new locus tag: SPCG_RS12290 ]
  • pan locus tag?: PNEUPAN001940000
  • symbol: SPCG_0928
  • pan gene symbol?: ald
  • synonym:
  • product: alanine dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPCG_0928 [new locus tag: SPCG_RS12290 ]
  • symbol: SPCG_0928
  • product: alanine dehydrogenase
  • replicon: chromosome
  • strand: -
  • coordinates: 909181..910008
  • length: 828
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGTTAATCGGAATCCCAAAAGAAATTAAAAATAACGAAAACCGTGTCGCCCTCACACCT
    GCAGGTGTTCATAGCTTAGTTAGTCGTGGTCATCGTGTCCTTATCGAAACAAATGCTGGT
    CTCGGTTCTGGCTTTACTGATGCTGACTATCAAAAGCAAGGAGCTGAGATTGTCGCTACT
    GCTGGTGAAGCTTGGGCAGCAGAGTTGGTTGTGAAAGTAAAAGAATCTTTAAGTTCTGAA
    TACGGTTACTTGCGCGACGATCTTCTTCTCTTCACCTACTTGCACATGGCCGCTGCTCCA
    GAATTAGCAGATGCTATGTTAACAGCAAAAACAACTGAAACTGTTCGTGACAATCAAGGA
    CAACTACCGCTCCTCGTTCCTATGAGTGAGGTTGCAGGTCGTATGGCTGTTCAAATCGGA
    GCTCACTTCCTTACTAAGCAAGCTGGTGGCTCTGGTGTTCTACTTGGTGGTGTACCAGGT
    GTTCCAAAAGGAAAAGTAACTATCATCGGTGGTGGTGTCGTCGGTACACATGCTGCCCGC
    ATCGCCCTTGGTCTTGGTGCTCAAGTGACTATTTTAGATATTAGTTCCAAGCGTCTCTCA
    GTTCTAGAAGAAGTCTTTGGAAGTCAAATTCAAACTCTTATGTCTAATTCATTCAACATT
    GAAGCAAGTGTGAGAGATGCTGATGTGGTGATTGGAGCCATTCTCATCCCTGGTGCAAAA
    GCACCGGAATTGGTGACAGATGAGATGGTCAAACAAATGCGTCCAGGCTCTGTATCGTTG
    ACGTTGCTGTTGACCAAGGTGGCGTTATCGAAACAGCTGACCGTGTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    828

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPCG_0928 [new locus tag: SPCG_RS12290 ]
  • symbol: SPCG_0928
  • description: alanine dehydrogenase
  • length: 275
  • theoretical pI: 6.69167
  • theoretical MW: 28787.2
  • GRAVY: 0.276

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Energy metabolism Amino acids and amines alanine dehydrogenase (TIGR00518; EC 1.4.1.1; HMM-score: 398.6)
    and 11 more
    Metabolism Energy metabolism Electron transport NAD(P)(+) transhydrogenase (AB-specific), alpha subunit (TIGR00561; EC 1.6.1.2; HMM-score: 107.9)
    dihydrolipoyl dehydrogenase (TIGR01350; EC 1.8.1.4; HMM-score: 21.8)
    Cellular processes Cellular processes Detoxification mercury(II) reductase (TIGR02053; EC 1.16.1.1; HMM-score: 19.6)
    mycothione reductase (TIGR03452; EC 1.8.1.15; HMM-score: 18.6)
    6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase (TIGR03201; EC 1.1.1.-; HMM-score: 17.6)
    Metabolism Energy metabolism Electron transport glutathione-disulfide reductase (TIGR01424; EC 1.8.1.7; HMM-score: 17.2)
    nucleotide sugar dehydrogenase (TIGR03026; HMM-score: 16.8)
    FAD dependent oxidoreductase TIGR03364 (TIGR03364; HMM-score: 15.5)
    Cellular processes Cellular processes Cell division septum site-determining protein MinD (TIGR01968; HMM-score: 13.6)
    Cellular processes Cellular processes Biosynthesis of natural products 2,3-diaminopropionate biosynthesis protein SbnB (TIGR03944; HMM-score: 13.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin siroheme synthase, N-terminal domain (TIGR01470; HMM-score: 12.9)
  • TheSEED  :
    • Alanine dehydrogenase (EC 1.4.1.1)
    Carbohydrates Central carbohydrate metabolism Pyruvate Alanine Serine Interconversions  Alanine dehydrogenase (EC 1.4.1.1)
  • PFAM:
    NADP_Rossmann (CL0063) AlaDh_PNT_C; Alanine dehydrogenase/PNT, C-terminal domain (PF01262; HMM-score: 154.7)
    Form_Glyc_dh (CL0325) AlaDh_PNT_N; Alanine dehydrogenase/PNT, N-terminal domain (PF05222; HMM-score: 136.1)
    and 12 more
    NADP_Rossmann (CL0063) Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase (PF00070; HMM-score: 26.9)
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase (PF07992; HMM-score: 23.8)
    2-Hacid_dh_C; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (PF02826; HMM-score: 23.2)
    3HCDH_N; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (PF02737; HMM-score: 22.6)
    NAD_binding_7; Putative NAD(P)-binding (PF13241; HMM-score: 19.5)
    Shikimate_DH; Shikimate / quinate 5-dehydrogenase (PF01488; HMM-score: 18.3)
    ADH_zinc_N; Zinc-binding dehydrogenase (PF00107; HMM-score: 15.7)
    TrkA_N; TrkA-N domain (PF02254; HMM-score: 15)
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent (PF03807; HMM-score: 13.9)
    UDPG_MGDP_dh_N; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain (PF03721; HMM-score: 13.5)
    GIDA; Glucose inhibited division protein A (PF01134; HMM-score: 13)
    DAO; FAD dependent oxidoreductase (PF01266; HMM-score: 12.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.95
    • Cytoplasmic Membrane Score: 0.05
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.8451
    • Cytoplasmic Membrane Score: 0.0697
    • Cell wall & surface Score: 0.0018
    • Extracellular Score: 0.0835
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.011119
    • TAT(Tat/SPI): 0.005091
    • LIPO(Sec/SPII): 0.001014
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACB90180 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MLIGIPKEIKNNENRVALTPAGVHSLVSRGHRVLIETNAGLGSGFTDADYQKQGAEIVATAGEAWAAELVVKVKESLSSEYGYLRDDLLLFTYLHMAAAPELADAMLTAKTTETVRDNQGQLPLLVPMSEVAGRMAVQIGAHFLTKQAGGSGVLLGGVPGVPKGKVTIIGGGVVGTHAARIALGLGAQVTILDISSKRLSVLEEVFGSQIQTLMSNSFNIEASVRDADVVIGAILIPGAKAPELVTDEMVKQMRPGSVSLTLLLTKVALSKQLTV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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