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serotype 4
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serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
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AP200
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ASP0581
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ATCC 49619
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BVJ1JL
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CGSP14
serotype 14
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serotype 19F
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Hu15
serotype 19A
Hu17
serotype 19A
INV104
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INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
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TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-JAN-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae CGSP14
  • locus tag: SPCG_RS00435 [old locus tag: SPCG_0080 ]
  • pan locus tag?: PNEUPAN000734000
  • symbol: pavB
  • pan gene symbol?: pavB
  • synonym:
  • product: fibronectin-binding SSURE repeat adhesin PavB

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS, pseudogene
  • locus tag: SPCG_RS00435 [old locus tag: SPCG_0080 ]
  • symbol: pavB
  • product: fibronectin-binding SSURE repeat adhesin PavB
  • replicon: chromosome
  • strand: +
  • coordinates: 80645..84131
  • length: 3487
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
    3301
    3361
    3421
    3481
    ATGAAATTCAATCCAAATCAAAGATATACTCGTTGGTCTATTCAGCCGTCTCAGTGTCGG
    TGTTGCCTCAGTTGTTGTGGCTAGTGGCTTCTTTGTCCTAGTTGGTCAGCCAAGTTCTGT
    ACGTGCCGATGGGCTCAATCCAACCCCAGGTCAAGTATTACCTGAAGAGACATCGGGAAC
    GAAAGAGGGTGACTTATCAGAAAAACCAGGAGACACCGTTCTCACTCAAGCGAAACCTGA
    GGGCGTTACTGGAAATACGAATTCACTTCCGACACCTACAGAAAGAACTGAAGTGAGCGA
    GGAAACAAGCCCTTCTAGTCTGGATACACTTTTTGAAAAAGATGAAGAAGCTCAAAAAAA
    TCCAGAGCTAACAGATGTCTTAAAAGAAACTGTAGATACAGCTGATGTGGATGGGACACA
    AGCAAGTCCAGCAGAAACTACTCCTGAACAAGTAAAAGGTGGAGTGAAAGAAAATACAAA
    AGACAGCATCGATGTTCCTGCTGCTTATCTTGAAAAAGCTGAAGGGAAAGGTCCTTTCAC
    TGCCGGTGTAAACCAAGTAATTCCTTATGAACTATTCGCTGGTGATGGTATGTTAACTCG
    TCTATTACTAAAAGCTTCGGATAATGCTCCTTGGTCTGACAATGGTACTGCTAAAAATCC
    TGCTTTACCTCCTCTTGAAGGATTAACAAAAGGGAAATACTTCTATGAAGTAGACTTAAA
    TGGCAATACTGTTGGTAAACAAGGTCAAGCTTTAATTGATCAACTTCGCGCTAATGGTAC
    TCAAACTTATAAAGCTACTGTTAAAGTTTACGGAAATAAAGACGGTAAAGCTGACTTGAC
    TAATCTAGTTGCTACTAAAAATGTAGACATCAACATCAATGGATTAGTTGCTAAAGAAAC
    TGTCGAAAAAGCTGTTAAAGATAACGTTAAAGACAGTATCGATGTTCCAGCAGCCTACCT
    AGAAAAGGCCAAGGGTGAAGGTCCATTCACAGCAGGTGTCAACCATGTGATTCCATACGA
    ACTCTTCGCAGGTGATGGTATGTTGACTCGTCTCTTGCTCAAGGCATCTGACAAGGCACC
    ATGGTCAGATAACGGTGAGGCTAAAAACCCAGCCCTATCTCCACTAGGCGAAAACGTGAA
    GACCAAAGGTCAATACTTCTATCAAGTAGCCTTGGACGGAAATGTAGCTGGCAAAGAAAA
    ACAAGCGCTCATTGACCAGTTCCGAGCAAATGGTACTCAAACTTACAGCGCTACAGTCAA
    TGTCTATGGTAACAAAGACGGTAAACCAGACTTGGACAACATCGTAGCAACTAAAAAAGT
    CACTATTAACATAAACGGTTTAATTTCTAAAGAAACAGTTCAAAAAGCCGTTGCAGACAA
    CGTTAAGGACAGTATCGATGTTCCAGCAGCCTACCTAGAAAAGGCCAAGGGTGAAGGTCC
    ATTCACAGCAGGTGTCAACCATGTGATTCCATACGAACTCTTCGCAGGTGATGGTATGTT
    GACTCGTCTCTTGCTCAAGGCATCTGACAAGGCACCATGGTCAGATAACGGTGACGCTAA
    AAACCCAGCCCTATCTCCACTAGGTGAAAACGTGAAGACCAAAGGTCAATACTTCTATCA
    ATTAGCCTTGGACGGAAATGTAGCTGGCAAAGAAAAACAAGCGCTCATTGACCAGTTCCG
    AGCAAACGGTACTCAAACTTACAGCGCTACAGTCAATGTCTATGGTAACAAAGACGGTAA
    ACCAGACTTGGACAACATCGTAGCAACTAAAAAAGTCACTATTAACATAAACGGTTTAAT
    TTCTAAAGAAACAGTTCAAAAAGCCGTTGCAGACAACGTTAAGGACAGTATCGATGTTCC
    AGCAGCCTACCTAGAAAAGGCCAAGGGTGAAGGTCCATTCACAGCAGGTGTCAACCATGT
    GATTCCATACGAACTCTTCGCAGGTGATGGTATGTTGACTCGTCTCTTGCTCAAGGCATC
    TGACAAGGCACCATGGTCAGATAACGGTGACGCTAAAAACCCAGCCCTATCTCCACTAGG
    TGAAAACGTGAAGACCAAAGGTCAATACTTCTATCAATTAGCCTTGGACGGAAATGTAGC
    TGGCAAAGAAAAACAAGCGCTCATTGACCAGTTCCGAGCAAACGGTACTCAAACTTACAG
    CGCTACAGTCAATGTCTATGGTAACAAAGACGGTAAACCAGACTTGGACAACATCGTAGC
    AACTAAAAAAGTCACTATTAACATAAACGGTTTAATTTCTAAAGAAACAGTTCAAAAAGC
    CGTTGCAGACAACGTTAAAGACAGTATCGATGTTCCAGCAGCCTACCTAGAAAAAGCCAA
    GGGTGAAGGTCCATTCACAGCAGGTGTCAACCATGTGATTCCATACGAACTCTTCGCAGG
    TGATGGTATGTTGACTCGTCTCTTGCTCAAGGCATCTGACAAGGCACCGTGGTCAGATAA
    CGGCGACGCTAAAAACCCAGCCCTATCTCCACTAGGCGAAAACGTGAAGACCAAAGGTCA
    ATACTTCTATCAATTAGCCTTGGACGGAAATGTAGCTGGCAAAGAAAAACAAGCGCTCAT
    TGACCAGTTCCGAGCAAATGGTACTCAAACTTACAGCGCTACAGTCAATGTCTATGGTAA
    CAAAGACGGTAAACCAGACTTGGACAACATCGTAGCAACTAAAAAAGTCACTATTAACAT
    AAACGGTTTAATTTCTAAAGAAACAGTTCAAAAAGCCGTTGCAGACAACGTTAAAGACAG
    TATCGATGTTCCAGCAGCCTACTTAGAAAAAGCCAAGGGTGAAGGTCCATTCACAGCAGG
    TGTCAACCATGTGATTCCATACGAACTCTTCGCAGGTGATGGTATGTTGACTCGTCTCTT
    GCTCAAGGCATCTGACAAGGCACCATGGTCAGATAACGGTGAGGCTAAAAACCCAGCTCT
    ATCTCCACTAGGCGAAAACGTGAAGACCAAAGGTCAATACTTCTATCAAGTAGCCTTGGA
    CGGAAATGTAGCTGGCAAAGAAAAACAAGCGCTCATTGACCAGTTCCGAGCAAACGGTAC
    TCAAACTTACAGCGCTACAGTCAATGTCTATGGTAACAAAGACGGTAAACCAGACTTGGA
    CAACATCGTAGCAACTAAAAAAGTCACTATTAAGATAAATGTTAAAGAAACATCAGACAC
    AGCAAATGGTTCATTATCACCTTCTAACTCTGGTTCTGGCGTGACTCCGATGAATCACAA
    TCATGCTACAGGTACTACAGATAGCATGCCTGCTGACACCATGACAAGTTCTACCAACAC
    GATGGCAGGTGAAAACATGGCTGCTTCTGCTAACAAGATGTCTGATACGATGATGTCAGA
    GGATAAAGCTATGCTACCAAATACTGGTGAGACTCAAACATCAATGGCAAGTATTGGTTT
    CCTTGGGCTTGCGCTTGCAGGTTTACTCGGTGGTCTAGGTTTGAAAAACAAAAAAGAAGA
    AAACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2880
    2940
    3000
    3060
    3120
    3180
    3240
    3300
    3360
    3420
    3480
    3487

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPCG_RS00435 [old locus tag: SPCG_0080 ]
  • symbol: PavB
  • description: fibronectin-binding SSURE repeat adhesin PavB
  • length:
  • theoretical pI:
  • theoretical MW:
  • GRAVY:

⊟Function[edit | edit source]

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb:
  • SignalP:
  • predicted transmembrane helices (TMHMM):

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Inga Jensch, Gustavo Gámez, Michael Rothe, Sandra Ebert, Marcus Fulde, Daniela Somplatzki, Simone Bergmann, Lothar Petruschka, Manfred Rohde, Roland Nau, Sven Hammerschmidt
PavB is a surface-exposed adhesin of Streptococcus pneumoniae contributing to nasopharyngeal colonization and airways infections.
Mol Microbiol: 2010, 77(1);22-43
[PubMed:20444103] [WorldCat.org] [DOI] (I p)Ulrike Binsker, Thomas P Kohler, Krystin Krauel, Sylvia Kohler, Hansjörg Schwertz, Sven Hammerschmidt
Pneumococcal Adhesins PavB and PspC Are Important for the Interplay with Human Thrombospondin-1.
J Biol Chem: 2015, 290(23);14542-55
[PubMed:25897078] [WorldCat.org] [DOI] (I p)Sajida Kanwal, Inga Jensch, Gottfried J Palm, Mark Brönstrup, Manfred Rohde, Thomas P Kohler, Daniela Somplatzki, Werner Tegge, Howard F Jenkinson, Sven Hammerschmidt
Mapping the recognition domains of pneumococcal fibronectin-binding proteins PavA and PavB demonstrates a common pattern of molecular interactions with fibronectin type III repeats.
Mol Microbiol: 2017, 105(6);839-859
[PubMed:28657670] [WorldCat.org] [DOI] (I p)

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