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serotype 4
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TCH8431/19A
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Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 16-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae CGSP14
  • locus tag: SPCG_RS03500 [old locus tag: SPCG_0667 ]
  • pan locus tag?: PNEUPAN001640000
  • symbol: thiE
  • pan gene symbol?: thiE-1
  • synonym:
  • product: thiamine phosphate synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPCG_RS03500 [old locus tag: SPCG_0667 ]
  • symbol: thiE
  • product: thiamine phosphate synthase
  • replicon: chromosome
  • strand: +
  • coordinates: 670749..671378
  • length: 630
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGTTTCATAAAGAATTACTAAAACTATATTTTATTTGTGGAACGACTACTTGCCAAGGA
    AAAAATCTATATACAGTCGTTGAGGAAGCCTTAAGAGGTGGTATAACCTTATTTCAATTT
    CGAGAAAAAGGTGAGGGTGCTTTAGAAGGCTTAGAAAAACTTGAGCTAGCTATCCAAATT
    AAAGAACTTTGTAAAAAATACAATGTGCCGTTTATCGTTAATGATGATATCGATTTGGCA
    ATGGAAATTGACGCTGATGGCGTACATGTAGGTCAAGATGATATTGGTGTTGATGAAATT
    AGAAAATTGATGCCAGATAAAATAATTGGTCTTTCTATAAAAAACGAGGAAGAATTTCAA
    CAATCAAAAGTTGAATATGTAGATTATGTTGGTGTTGGTCCTGTATTTGATACCCAGTCA
    AAGGATGATGCTGGTGGTGCTATAGGTTATGAAGGTGTTAAATTGATGAGAAAACTATTG
    CCACAAATGCCCTTAGTTGCAATTGGTGGGATACAGACGAAACATATTAAAGACATTATG
    AAGACCAATGTTGACGGCGTTTCAATCATTTCGGCAATATCGTATGCAAAAAATATAGAA
    AAAACTGTTCGGGAAATGAGTGAACAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    630

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPCG_RS03500 [old locus tag: SPCG_0667 ]
  • symbol: ThiE
  • description: thiamine phosphate synthase
  • length: 209
  • theoretical pI: 4.69062
  • theoretical MW: 23274.8
  • GRAVY: -0.14067

⊟Function[edit | edit source]

  • reaction:
    EC 2.5.1.3?  ExPASy
    Thiamine phosphate synthase 4-amino-2-methyl-5-diphosphomethylpyrimidine + 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate = diphosphate + thiamine phosphate + CO2 4-amino-2-methyl-5-diphosphomethylpyrimidine + 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate = diphosphate + thiamine phosphate + CO2 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphono-oxyethyl)thiazole = diphosphate + thiamine phosphate
  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine thiamine-phosphate diphosphorylase (TIGR00693; EC 2.5.1.3; HMM-score: 220.3)
    and 1 more
    3-hexulose-6-phosphate synthase (TIGR03128; EC 4.1.2.43; HMM-score: 16.4)
  • TheSEED: see SPCG_0667
  • PFAM:
    TIM_barrel (CL0036) TMP-TENI; Thiamine monophosphate synthase (PF02581; HMM-score: 206.3)
    and 3 more
    QRPTase_C; Quinolinate phosphoribosyl transferase, C-terminal domain (PF01729; HMM-score: 15.5)
    Dus; Dihydrouridine synthase (Dus) (PF01207; HMM-score: 12.5)
    ThiG; Thiazole biosynthesis protein ThiG (PF05690; HMM-score: 11.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9834
    • Cytoplasmic Membrane Score: 0.0124
    • Cell wall & surface Score: 0.0008
    • Extracellular Score: 0.0035
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.018474
    • TAT(Tat/SPI): 0.001083
    • LIPO(Sec/SPII): 0.185106
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000468587 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MFHKELLKLYFICGTTTCQGKNLYTVVEEALRGGITLFQFREKGEGALEGLEKLELAIQIKELCKKYNVPFIVNDDIDLAMEIDADGVHVGQDDIGVDEIRKLMPDKIIGLSIKNEEEFQQSKVEYVDYVGVGPVFDTQSKDDAGGAIGYEGVKLMRKLLPQMPLVAIGGIQTKHIKDIMKTNVDGVSIISAISYAKNIEKTVREMSEQ

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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