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serotype 4
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Xen35
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gamPNI0373
serotype 1

NCBI: 16-DEC-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae CGSP14
  • locus tag: SPCG_RS07050 [old locus tag: SPCG_1363 ]
  • pan locus tag?: PNEUPAN002649000
  • symbol: SPCG_RS07050
  • pan gene symbol?: tyrA
  • synonym:
  • product: prephenate dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPCG_RS07050 [old locus tag: SPCG_1363 ]
  • symbol: SPCG_RS07050
  • product: prephenate dehydrogenase
  • replicon: chromosome
  • strand: -
  • coordinates: 1348077..1349180
  • length: 1104
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    ATGGCAAAAACAATCTATATCGCAGGTCTTGGGTTGATTGGAGCCTCTATGGCACTTGGT
    ATCAAACGCGATCATCCAGATTATGAAATTTTAGGTTATAATCGTAGTCAAGCTTCGAGA
    GATATCGCCTTGAAAGAAGGTATGATTGACCGTGCAACGGATGATTTTGCTAGTTTTGCT
    CCTTTGGCAGATGTCATTATCCTCAGCTTGCCAATCAAACAAACTATTGCTTTCATTAAG
    GAGTTGGCCAATTTGGATTTGCGAGAAGGCGTTATTATTTCAGATGCTGGTTCGACCAAG
    TCAACCATTGTGGATGCGGCGGAGCAGTATTTGGCTGGCAAGTCTGTTCGCTTTGTCGGG
    GCCCATCCCATGGCTGGTAGTCACAAGACAGGGGCTGCTTCGGCAGATGTCAATCTTTTT
    GAAAATGCCTATTATATCTTTACACCTTCAAGCCTGACAAGTCAGGACACGCTTAAGGAA
    ATGAAGGATCTGCTTTCAGGTCTTCATGCTCGTTTTATCGAGATTGATGCCAAGGAGCAT
    GATCGTGTCACTTCTCAGATTAGCCATTTTCCTCATATTTTGGCTTCTAGTCTCATGGAG
    CAGACTGCGGTCTATGCTCAAGAGCATGAGATGGCAAGGCGCTTTGCGGCAGGTGGTTTT
    CGAGATATGACCCGAATTGCGGAAAGCGAGCCAGGAATGTGGACCTCCATTCTCTTGTCC
    AATAGCGAGACCATTCTGGATAGAATTGAGGATTTCAAGGAACGTTTGGAAGTGATTGGT
    CAGGCCATTAGTAAGGGAGATGAAGAGCAAATTTGGAACTTTTTTAACCAAGCGCGTGAA
    CAACGCCAGACCATGGAAATCCATAAGCGTGGTGGTGTGGATAGCTCTTACGACCTCTAT
    GTTGACGTTCCTGATGAAGAAGATGTCATCCTGCGGATTTTGGAACTGCTACGTGGAACT
    TCCTTGGTTAACATCCACATCAACGAGGAAAATCGTGAGGATATTCACGGAATCCTACAA
    ATTTCATTTAAAAATGCTCAAGACTTGGAAAGAGCTGAGCATCTCATAACAGAAAATACC
    GACTATACAGTCGTCATCAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1104

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPCG_RS07050 [old locus tag: SPCG_1363 ]
  • symbol: SPCG_RS07050
  • description: prephenate dehydrogenase
  • length: 367
  • theoretical pI: 4.74274
  • theoretical MW: 41030.1
  • GRAVY: -0.220981

⊟Function[edit | edit source]

  • reaction:
    EC 1.3.1.12?  ExPASy
    Prephenate dehydrogenase Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Glutamate family pyrroline-5-carboxylate reductase (TIGR00112; EC 1.5.1.2; HMM-score: 17.2)
  • TheSEED: see SPCG_1363
  • PFAM:
    NADP_Rossmann (CL0063) PDH_N; Prephenate dehydrogenase, nucleotide-binding domain (PF02153; HMM-score: 125.4)
    and 5 more
    6PGD_C (CL0106) PDH_C; Prephenate dehydrogenase, dimerization domain (PF20463; HMM-score: 99.6)
    NADP_Rossmann (CL0063) NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase (PF03446; HMM-score: 38.5)
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent (PF03807; HMM-score: 27.2)
    2-Hacid_dh_C; D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain (PF02826; HMM-score: 18)
    P-loop_NTPase (CL0023) AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 16.5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.976
    • Cytoplasmic Membrane Score: 0.0193
    • Cell wall & surface Score: 0.0004
    • Extracellular Score: 0.0043
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.162095
    • TAT(Tat/SPI): 0.005506
    • LIPO(Sec/SPII): 0.130393
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001140486 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MAKTIYIAGLGLIGASMALGIKRDHPDYEILGYNRSQASRDIALKEGMIDRATDDFASFAPLADVIILSLPIKQTIAFIKELANLDLREGVIISDAGSTKSTIVDAAEQYLAGKSVRFVGAHPMAGSHKTGAASADVNLFENAYYIFTPSSLTSQDTLKEMKDLLSGLHARFIEIDAKEHDRVTSQISHFPHILASSLMEQTAVYAQEHEMARRFAAGGFRDMTRIAESEPGMWTSILLSNSETILDRIEDFKERLEVIGQAISKGDEEQIWNFFNQAREQRQTMEIHKRGGVDSSYDLYVDVPDEEDVILRILELLRGTSLVNIHINEENREDIHGILQISFKNAQDLERAEHLITENTDYTVVIK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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