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TCH8431/19A
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Xen35
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serotype 1

NCBI: 24-JAN-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae CGSP14
  • locus tag: SPCG_RS10210 [old locus tag: SPCG_1947 ]
  • pan locus tag?: PNEUPAN003568000
  • symbol: rsgA
  • pan gene symbol?: rsgA
  • synonym:
  • product: ribosome small subunit-dependent GTPase A

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPCG_RS10210 [old locus tag: SPCG_1947 ]
  • symbol: rsgA
  • product: ribosome small subunit-dependent GTPase A
  • replicon: chromosome
  • strand: -
  • coordinates: 1931110..1931988
  • length: 879
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGCAGGGACAAATCATTAAAGCCTTGGCAGGTTTCTACTATGTGGAGAGTGATGGCCAG
    GTTTATCAAACACGCGCGCGTGGGAATTTCCGTAAAAAAGGCCATACCCCTTATGTTGGG
    GACTGGGTAGATTTCTCTGCCGAGGAAAATTCAGAAGGCTATATCCTAAAAATTCACGAA
    CGGAAAAACAGTCTGGTTCGTCCGCCTATTGTCAATATCGATCAAGCTGTAGTAATCATG
    TCCGTCAAGGAACCTGATTTTAACAGCAATTTGCTGGATCGTTTCTTGGTTCTTTTGGAG
    CACAAGGGCATCCATCCCATTGTCTATATTTCCAAAATGGATTTGTTGGAAGATAGGGGA
    GAACTGGATTTTTACCGGCAGACCTATGGTGACATCGGCTATGACTTTGTGACCAGTAAA
    AAGGAACTCCTGTCTTTGTTAACAGGCAAGGTTACGGTCTTTATGGGGCAGACAGGTGTT
    GGGAAGTCAACTCTTCTCAATAAACTCGTACCAGACCTTAATCTTGAAACGGGAGAAATT
    TCAGACAGTCTGGGTCGCGGGCGCCATACCACTCGAGCTGTTAGTTTTTACAATCTCAAC
    GGGGGTAAAATCGCAGATACACCAGGCTTTTCATCTCTGGACTATGAAGTATCAAGGGCT
    GAAGACCTCAATCAGGCCTTTCCAGAGATTGCTACTGTCAGCCGAGATTGTAAGTTTCGT
    ACTTGTACCCATACCCATGAGCCGTCTTGTGCCGTCAAGCCAGCTGTAGAAGAGGGGACC
    ATTGCCACCTTCCGTTTTGACAACTACCTGCAATTCCTCAGCGAAATTGAAAATCGTAGA
    GAAACCTATAAAAAAGTCAGCAAAAAAATTCCAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    879

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPCG_RS10210 [old locus tag: SPCG_1947 ]
  • symbol: RsgA
  • description: ribosome small subunit-dependent GTPase A
  • length: 292
  • theoretical pI: 7.19531
  • theoretical MW: 33050.3
  • GRAVY: -0.409589

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein synthesis Translation factors ribosome small subunit-dependent GTPase A (TIGR00157; EC 3.6.-.-; HMM-score: 246.1)
    and 29 more
    Genetic information processing Protein synthesis Other ribosome biogenesis GTPase YqeH (TIGR03597; HMM-score: 23.9)
    Genetic information processing Protein synthesis Other ribosome biogenesis GTP-binding protein YsxC (TIGR03598; HMM-score: 21.2)
    Metabolism Transport and binding proteins Amino acids, peptides and amines urea ABC transporter, ATP-binding protein UrtE (TIGR03410; HMM-score: 19.8)
    Unknown function General small GTP-binding protein domain (TIGR00231; HMM-score: 19.3)
    Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 17.7)
    Cellular processes Cellular processes Toxin production and resistance putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 16.4)
    Metabolism Transport and binding proteins Unknown substrate putative bacteriocin export ABC transporter, lactococcin 972 group (TIGR03608; HMM-score: 16.4)
    Metabolism Transport and binding proteins Cations and iron carrying compounds cobalt ABC transporter, ATP-binding protein (TIGR01166; HMM-score: 16)
    phosphonate C-P lyase system protein PhnL (TIGR02324; HMM-score: 15.3)
    Genetic information processing Protein synthesis Other GTP-binding protein Era (TIGR00436; HMM-score: 15.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other FeS assembly ATPase SufC (TIGR01978; HMM-score: 14.9)
    Metabolism Transport and binding proteins Unknown substrate energy-coupling factor transporter ATPase (TIGR04521; EC 3.6.3.-; HMM-score: 14.5)
    Genetic information processing Protein synthesis Other ribosome-associated GTPase EngA (TIGR03594; HMM-score: 14)
    Metabolism Transport and binding proteins Anions phosphate ABC transporter, ATP-binding protein (TIGR00972; EC 3.6.3.27; HMM-score: 13.9)
    Metabolism Central intermediary metabolism Phosphorus compounds phosphonate C-P lyase system protein PhnK (TIGR02323; HMM-score: 13.4)
    Metabolism Energy metabolism Amino acids and amines ethanolamine utilization protein, EutP (TIGR02528; HMM-score: 13)
    Genetic information processing Protein synthesis Other ribosome biogenesis GTP-binding protein YlqF (TIGR03596; HMM-score: 13)
    proposed F420-0 ABC transporter, ATP-binding protein (TIGR03873; HMM-score: 12.6)
    Metabolism Transport and binding proteins Amino acids, peptides and amines choline ABC transporter, ATP-binding protein (TIGR03415; HMM-score: 12.3)
    thiol reductant ABC exporter, CydC subunit (TIGR02868; HMM-score: 12.2)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system (TIGR03864; HMM-score: 11.9)
    thiol reductant ABC exporter, CydD subunit (TIGR02857; HMM-score: 11.8)
    Metabolism Transport and binding proteins Other pleiotropic drug resistance family protein (TIGR00956; HMM-score: 11.6)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 11.5)
    Metabolism Transport and binding proteins Other heme ABC exporter, ATP-binding protein CcmA (TIGR01189; EC 3.6.3.41; HMM-score: 11.5)
    Metabolism Transport and binding proteins Anions phosphonate ABC transporter, ATP-binding protein (TIGR02315; EC 3.6.3.28; HMM-score: 11.2)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA 2-selenouridine synthase (TIGR03167; EC 2.9.1.-; HMM-score: 11.2)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA modification GTPase TrmE (TIGR00450; EC 3.6.-.-; HMM-score: 10.9)
    Genetic information processing Protein fate Protein modification and repair [FeFe] hydrogenase H-cluster maturation GTPase HydF (TIGR03918; HMM-score: 10.3)
  • TheSEED: see SPCG_1947
  • PFAM:
    P-loop_NTPase (CL0023) RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 195.6)
    and 16 more
    OB (CL0021) RsgA_N; RsgA N-terminal domain (PF16745; HMM-score: 88.6)
    P-loop_NTPase (CL0023) MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 32.3)
    ABC_tran; ABC transporter (PF00005; HMM-score: 25.2)
    GTP_EFTU; Elongation factor Tu GTP binding domain (PF00009; HMM-score: 18.2)
    AAA_22; AAA domain (PF13401; HMM-score: 16.2)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 16.1)
    RNA_helicase; RNA helicase (PF00910; HMM-score: 15)
    AAA_23; AAA domain (PF13476; HMM-score: 13.9)
    NACHT; NACHT domain (PF05729; HMM-score: 13.5)
    FeoB_N; Ferrous iron transport protein B (PF02421; HMM-score: 13.4)
    AAA_16; AAA ATPase domain (PF13191; HMM-score: 12.7)
    AAA_25; AAA domain (PF13481; HMM-score: 12.3)
    Dynamin_N; Dynamin family (PF00350; HMM-score: 12)
    cobW; CobW/HypB/UreG, nucleotide-binding domain (PF02492; HMM-score: 11.2)
    NTPase_P4; ATPase P4 of dsRNA bacteriophage phi-12 (PF11602; HMM-score: 11.1)
    T2SSE; Type II/IV secretion system protein (PF00437; HMM-score: 11)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.022301
    • TAT(Tat/SPI): 0.001721
    • LIPO(Sec/SPII): 0.003898
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MQGQIIKALAGFYYVESDGQVYQTRARGNFRKKGHTPYVGDWVDFSAEENSEGYILKIHERKNSLVRPPIVNIDQAVVIMSVKEPDFNSNLLDRFLVLLEHKGIHPIVYISKMDLLEDRGELDFYRQTYGDIGYDFVTSKKELLSLLTGKVTVFMGQTGVGKSTLLNKLVPDLNLETGEISDSLGRGRHTTRAVSFYNLNGGKIADTPGFSSLDYEVSRAEDLNQAFPEIATVSRDCKFRTCTHTHEPSCAVKPAVEEGTIATFRFDNYLQFLSEIENRRETYKKVSKKIPK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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