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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-MAY-2018

Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_0133 [new locus tag: SPD_RS00740 ]
  • pan locus tag?: PNEUPAN000825000
  • symbol: SPD_0133
  • pan gene symbol?: cibA
  • synonym:
  • product: hypothetical protein

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SPD_0133 [new locus tag: SPD_RS00740 ]
  • symbol: SPD_0133
  • product: hypothetical protein
  • replicon: chromosome
  • strand: -
  • coordinates: 137522..137707
  • length: 186
  • essential: unknown

Accession numbers[edit | edit source]

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    ATGACAAATTTTGACATTCTTGACAATCAATTTTTATCCTTATCTGAAAATGAATTGTCA
    GATATTGATGGCGGTCTCGCTCCCTTGGTTATCTTTGGAGTAGCAGTATCTTGGAAGGCT
    ATTGCAGGTGGAACAGCACTTATAGGTTCTGGTTTGGCAGCTGGTTATTTTTTAGGAGGA
    GATTAA
    60
    120
    180
    186

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SPD_0133 [new locus tag: SPD_RS00740 ]
  • symbol: SPD_0133
  • description: hypothetical protein
  • length: 61
  • theoretical pI: 3.42376
  • theoretical MW: 6203.96
  • GRAVY: 0.645902

Function[edit | edit source]

  • TIGRFAM:
    class IIb bacteriocin, lactobin A/cerein 7B family (TIGR03949; HMM-score: 33.6)
  • TheSEED  :
    • Two-peptide bacteriocin peptide CibA
    Regulation and Cell signaling Programmed Cell Death and Toxin-antitoxin Systems Fratricide in Streptococcus  Two-peptide bacteriocin peptide CibA
  • PFAM:
    GG-leader (CL0400) Bacteriocin_IIc; Bacteriocin class II with double-glycine leader peptide (PF10439; HMM-score: 20.9)
    and 1 more
    Lactococcin; Lactococcin-like family (PF04369; HMM-score: 11.2)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.32
    • Cytoplasmic Membrane Score: 9.55
    • Cellwall Score: 0.12
    • Extracellular Score: 0.01
    • Internal Helix: 1
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.029139
    • TAT(Tat/SPI): 0.003436
    • LIPO(Sec/SPII): 0.002395
  • predicted transmembrane helices (TMHMM): 1

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MTNFDILDNQFLSLSENELSDIDGGLAPLVIFGVAVSWKAIAGGTALIGSGLAAGYFLGGD

Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Expression & Regulation[edit | edit source]

Regulation[edit | edit source]

  • regulator: ComX1 regulon
    ComX1(sigma factor)controls the expression of late competence genes [1]   other strains

Expression data[edit | edit source]

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

  1. Jelle Slager, Rieza Aprianto, Jan-Willem Veening
    Refining the Pneumococcal Competence Regulon by RNA Sequencing.
    J Bacteriol: 2019, 201(13);
    [PubMed:30885934] [WorldCat.org] [DOI] (I e)

Relevant publications[edit | edit source]