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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-MAY-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_0363 [new locus tag: SPD_RS01965 ]
  • pan locus tag?: PNEUPAN001267000
  • symbol: SPD_0363
  • pan gene symbol?: mtlD
  • synonym:
  • product: mannitol-1-phosphate 5-dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPD_0363 [new locus tag: SPD_RS01965 ]
  • symbol: SPD_0363
  • product: mannitol-1-phosphate 5-dehydrogenase
  • replicon: chromosome
  • strand: +
  • coordinates: 365539..366675
  • length: 1137
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    ATGAAACATTCTGTTCATTTTGGTGCCGGTAATATCGGTCGTGGTTTTATAGGTGAAATT
    CTATTTAAAAATGGTTTCCATATTGATTTTGTGGATGTCAATAATCAGATAATTCATGCT
    CTAAATGAAAAGGGCAAGTATGAAATTGAAATTGCACAGAAAGGACAGTCTCGTATAGAA
    GTAACTAATGTGGCTGGCATTAATAGCAAAGAACATCCTGAGCAAGTCATTGAAGCGATT
    CAAAAGACGGATATTATTACTACTGCAATCGGACCTAATATACTCCCTTTTATCGCTGAA
    CTTCTAGCCAAAGGAATCGAAGCTCGCCGAGTTGCAGGGAATACACAGGTATTGGATGTT
    ATGGCCTGTGAAAATATGATTGGCGGGTCTCAATTTCTTTATCAAGAAGTCAAGAAATAT
    TTAAGTCCGGAAGGTTTGACATTTGCTGATAACTACATAGGTTTTCCAAATGCTGCAGTA
    GACAGGATTGTTCCAGCACAAAGTCACGAAGATTCCCTTTTTGTTGTGGTCGAGCCCTTT
    AATGAATGGGTCGTGGAAACCAAGCGTCTTAAAAATCCAGATTTACGTCTAAAAGATGTG
    CATTATGAAGAAGATTTAGAACCCTTTATTGAGCGAAAACTTTTTTCAGTCAATTCTGGA
    CATGCAACTTCAGCTTACATTGGTGCGCATTATGGTGCCAAGACAATTTTGGAAGCTCTT
    CAAAATCCTAATATCAAATCTCGGATTGAATCTGTATTAGCTGAAATTCGGAGTCTCTTG
    ATTGCCAAATGGAACTTTGATAAAAAAGAATTGGAGAATTATCACAAAGTCATTATAGAA
    CGGTTTGAAAACCCTTTCATAGTGGACGAAGTTAGTCGCGTAGCTCGTACTCCAATCCGA
    AAATTAGGCTATAATGAACGATTCATCCGGCCGATACGTGAATTGAAAGAACTCAGTTTG
    TCATATAAAAACCTACTTAAAACAGTTGGCTATGCCTTTGACTATCGCGATGTAAATGAT
    GAAGAAAGTATTCGATTAGGTGAATTGTTGGCTAAACAATTAGTCAAAGATGTTGTTATA
    CAAGTTACAGGTTTAGACGACCAAGAATTGATTGAGCAAATTGTAGAGTATATTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1137

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPD_0363 [new locus tag: SPD_RS01965 ]
  • symbol: SPD_0363
  • description: mannitol-1-phosphate 5-dehydrogenase
  • length: 378
  • theoretical pI: 5.4995
  • theoretical MW: 42990.8
  • GRAVY: -0.212698

⊟Function[edit | edit source]

  • reaction:
    EC 1.1.1.17?  ExPASy
    Mannitol-1-phosphate 5-dehydrogenase D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH
  • TIGRFAM:
  • TheSEED  :
    • Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)
    Carbohydrates Sugar alcohols Mannitol Utilization  Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)
  • PFAM:
    6PGD_C (CL0106) Mannitol_dh_C; Mannitol dehydrogenase C-terminal domain (PF08125; HMM-score: 206.8)
    and 4 more
    NADP_Rossmann (CL0063) Mannitol_dh; Mannitol dehydrogenase Rossmann domain (PF01232; HMM-score: 95)
    no clan defined CofD; 2-phospho-L-lactate transferase CofD (PF01933; HMM-score: 16.7)
    NADP_Rossmann (CL0063) UDPG_MGDP_dh_N; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain (PF03721; HMM-score: 15.5)
    Transthyretin (CL0287) CooC_C; CS1-pili formation C-terminal (PF15976; HMM-score: 12.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00466
    • TAT(Tat/SPI): 0.000202
    • LIPO(Sec/SPII): 0.000372
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKHSVHFGAGNIGRGFIGEILFKNGFHIDFVDVNNQIIHALNEKGKYEIEIAQKGQSRIEVTNVAGINSKEHPEQVIEAIQKTDIITTAIGPNILPFIAELLAKGIEARRVAGNTQVLDVMACENMIGGSQFLYQEVKKYLSPEGLTFADNYIGFPNAAVDRIVPAQSHEDSLFVVVEPFNEWVVETKRLKNPDLRLKDVHYEEDLEPFIERKLFSVNSGHATSAYIGAHYGAKTILEALQNPNIKSRIESVLAEIRSLLIAKWNFDKKELENYHKVIIERFENPFIVDEVSRVARTPIRKLGYNERFIRPIRELKELSLSYKNLLKTVGYAFDYRDVNDEESIRLGELLAKQLVKDVVIQVTGLDDQELIEQIVEYI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: MtlR* (activation) regulon, CcpA regulon
    MtlR*(TF)important in Mannitol utilization; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 
    CcpA(TF)important in Global catabolite repression; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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