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serotype 4
D39
serotype 2
D39V
serotype 2
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serotype 19A
EF3030
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670-6B
serotype 6B
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serotype 6A
70585
serotype 5
A026
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A66
serotype 3
AP200
serotype 11A
ASP0581
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ATCC 49619
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ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-MAY-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_0661 [new locus tag: SPD_RS03555 ]
  • pan locus tag?: PNEUPAN001720000
  • symbol: exp5
  • pan gene symbol?: malT
  • synonym:
  • product: PTS system, IIABC components

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPD_0661 [new locus tag: SPD_RS03555 ]
  • symbol: exp5
  • product: PTS system, IIABC components
  • replicon: chromosome
  • strand: +
  • coordinates: 678906..681086
  • length: 2181
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    ATGATGAAAGATACATTCAAAAATGTCTTGTCTTTCGAATTTTGGCAAAAATTCGGTAAG
    GCTTTGATGGTAGTTATCGCGGTTATGCCGGCTGCTGGTTTGATGATTTCAATCGGTAAG
    TCTATCGTGATGATTAACCCAACCTTTGCACCACTTGTCATCACAGGTGGAATTCTTGAG
    CAAATCGGTTGGGGGGTTATCGGTAACCTTCACATTTTGTTTGCCCTAGCCATTGGAGGA
    AGCTGGGCTAAAGAACGTGCTGGTGGTGCTTTCGCCGCTGGTCTTGCCTTCATCTTGATT
    AACCGTATCACTGGTACAATCTTTGGTGTATCAGGCGATATGTTGAAAAATCCAGATGCT
    ATGGTAACTACTTTCTTTGGTGGTTCAATCAAAGTTGCTGATTACTTTATCAGTGTTCTT
    GAAGCTCCAGCCTTGAACATGGGGGTATTCGTAGGGATTATCTCAGGTTTTGTAGGGGCA
    ACTGCTTACAACAAATACTACAACTTCCGTAAACTTCCTGATGCACTTTCATTCTTCAAC
    GGGAAACGTTTCGTACCATTTGTAGTTATTCTTCGTTCAGCAATCGCTGCAATTCTACTT
    GCTGCTTTCTGGCCAGTAGTTCAAACAGGTATCAATAACTTCGGTATCTGGATTGCCAAC
    TCACAAGAAACTGCTCCAATTCTTGCACCATTCTTGTATGGTACTTTGGAACGTTTGCTC
    TTGCCATTTGGTCTTCACCACATGTTGACTATCCCAATGAACTACACAGCTCTTGGTGGT
    ACTTATGACATTTTAACTGGTGCAGCTAAAGGTACTCAAGTATTCGGTCAAGACCCACTA
    TGGCTTGCATGGGTAACAGACCTTGTAAACCTTAAAGGTACTGATGCTAGTCAATACCAA
    CACTTGTTAGATACAGTACATCCAGCTCGTTTCAAAGTTGGACAAATGATCGGTTCATTC
    GGTATCTTGATGGGTGTGATTGTTGCTATCTACCGTAATGTTGATGCTGACAAGAAACAT
    AAATACAAAGGTATGATGATTGCAACAGCTCTTGCAACATTCTTGACAGGGGTTACTGAA
    CCAATCGAATACATGTTCATGTTCATCGCAACACCTATGTATCTTGTTTACTCACTTGTT
    CAAGGTGCTGCCTTCGCTATGGCTGACGTCGTAAACCTACGTATGCACTCATTCGGTTCA
    ATCGAGTTCTTGACTCGTACACCTATTGCAATCAGTGCTGGTATTGGTATGGATATCGTT
    AACTTCGTTTGGGTAACTGTTCTCTTTGCTGTAATCATGTACTTTATCGCAAACTTCATG
    ATTCAAAAATTCAACTACGCAACTCCAGGGCGCAACGGAAACTACGAAACTGCTGAAGGT
    TCAGAAGAAACCAGCAGCGAAGTGAAAGTTGCAGCAGGCTCTCAAGCTGTAAACATTATC
    AACCTTCTTGGTGGACGTGTAAACATCGTTGATGTTGATGCATGTATGACTCGTCTTCGT
    GTAACTGTTAAAGATGCAGATAAAGTAGGAAATGCAGAGCAATGGAAAGCAGAAGGAGCT
    ATGGGTCTTGTGATGAAAGGACAAGGGGTTCAAGCTATCTACGGTCCAAAAGCTGACATT
    TTGAAATCTGATATCCAAGATATCCTTGATTCAGGTGAAATCATTCCTGAAACTCTTCCA
    AGCCAAATGACTGAAGTACAACAAAACACTGTTCACTTCAAAGATCTTACTGAGGAAGTT
    TACTCAGTAGCAGACGGTCAAGTTGTTGCTTTGGAACAAGTAAAGGATCCAGTATTTGCT
    CAAAAAATGATGGGTGATGGATTTGCAGTAGAACCTGCAAATGGAAACATTGTATCTCCA
    GTTTCAGGTACTGTATCAAGCATCTTCCCAACAAAACATGCTTTTGGTATTGTGACGGAA
    GCAGGTCTTGAAGTATTGGTTCACATTGGTTTGGACACAGTAAGTCTTGAAGGTAAACCA
    TTTACAGTTCATGTTGCTGAAGGACAAAAAGTTGCAGCAGGAGATCTCCTTGTCACAGCT
    GACTTGAATGCTATCCGTGCAGCAGGACGTGAAACTTCAACAGTAGTTGTCTTCACAAAT
    GGTGATGCAATTAAATCAGTTAAATTAGAAAAAACAGGTTCTCTTGCAGCTAAAACAGCA
    GTTGCTAAAGTAGAATTGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2181

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPD_0661 [new locus tag: SPD_RS03555 ]
  • symbol: Exp5
  • description: PTS system, IIABC components
  • length: 726
  • theoretical pI: 6.30565
  • theoretical MW: 78021.5
  • GRAVY: 0.439669

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.1.191?  ExPASy
    Protein-N(pi)-phosphohistidine--D-mannose phosphotransferase [Protein]-N(pi)-phospho-L-histidine + D-mannose(Side 1) = [protein]-L-histidine + D-mannose 6-phosphate(Side 2)
  • TIGRFAM:
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, IIBC component (TIGR02003; EC 2.7.1.69; HMM-score: 945.1)
    and 14 more
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, glucose-specific IIBC component (TIGR02002; EC 2.7.1.69; HMM-score: 319.8)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, N-acetylglucosamine-specific IIBC component (TIGR01998; EC 2.7.1.69; HMM-score: 286.7)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, maltose and glucose-specific IIBC component (TIGR02004; EC 2.7.1.69; HMM-score: 219.1)
    PTS system, beta-glucoside-specific IIABC component (TIGR01995; EC 2.7.1.69; HMM-score: 198.3)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, alpha-glucoside-specific IIBC component (TIGR02005; EC 2.7.1.69; HMM-score: 162.3)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, glucose subfamily, IIA component (TIGR00830; HMM-score: 145)
    Signal transduction Signal transduction PTS PTS system, glucose subfamily, IIA component (TIGR00830; HMM-score: 145)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, maltose and glucose-specific subfamily, IIC component (TIGR00852; HMM-score: 105.1)
    Signal transduction Signal transduction PTS PTS system, maltose and glucose-specific subfamily, IIC component (TIGR00852; HMM-score: 105.1)
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, glucose-like IIB component (TIGR00826; EC 2.7.1.69; HMM-score: 59.3)
    Signal transduction Signal transduction PTS PTS system, glucose-like IIB component (TIGR00826; EC 2.7.1.69; HMM-score: 59.3)
    PTS system, sucrose-specific IIBC component (TIGR01996; EC 2.7.1.69; HMM-score: 30.3)
    PTS system, trehalose-specific IIBC component (TIGR01992; EC 2.7.1.69; HMM-score: 20.2)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion membrane fusion protein, HlyD family (TIGR01843; HMM-score: 12.4)
  • TheSEED  :
    • PTS system, maltose and glucose-specific IIA component
    • PTS system, maltose and glucose-specific IIB component (EC 2.7.1.208)
    • PTS system, maltose and glucose-specific IIC component
    Carbohydrates Di- and oligosaccharides Maltose and Maltodextrin Utilization  PTS system, maltose and glucose-specific IIA component (EC 2.7.1.69)
    and 2 more
    Carbohydrates Di- and oligosaccharides Maltose and Maltodextrin Utilization  PTS system, maltose and glucose-specific IIB component (EC 2.7.1.69)
    Carbohydrates Di- and oligosaccharides Maltose and Maltodextrin Utilization  PTS system, maltose and glucose-specific IIC component (EC 2.7.1.69)
  • PFAM:
    Hybrid (CL0105) PTS_EIIA_1; phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 (PF00358; HMM-score: 172.4)
    PTS_EIIC (CL0493) PTS_EIIC; Phosphotransferase system, EIIC (PF02378; HMM-score: 168.3)
    and 5 more
    no clan defined PTS_EIIB; phosphotransferase system, EIIB (PF00367; HMM-score: 50.9)
    Hybrid (CL0105) Biotin_lipoyl_2; Biotin-lipoyl like (PF13533; HMM-score: 15.9)
    no clan defined GP44; Gene product 44 (PF17510; HMM-score: 14.1)
    Hybrid (CL0105) Peptidase_M23; Peptidase family M23 (PF01551; HMM-score: 13.3)
    no clan defined DUF6256; Family of unknown function (DUF6256) (PF19770; HMM-score: 13.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 8
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.083977
    • TAT(Tat/SPI): 0.002732
    • LIPO(Sec/SPII): 0.015116
  • predicted transmembrane helices (TMHMM): 9

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MMKDTFKNVLSFEFWQKFGKALMVVIAVMPAAGLMISIGKSIVMINPTFAPLVITGGILEQIGWGVIGNLHILFALAIGGSWAKERAGGAFAAGLAFILINRITGTIFGVSGDMLKNPDAMVTTFFGGSIKVADYFISVLEAPALNMGVFVGIISGFVGATAYNKYYNFRKLPDALSFFNGKRFVPFVVILRSAIAAILLAAFWPVVQTGINNFGIWIANSQETAPILAPFLYGTLERLLLPFGLHHMLTIPMNYTALGGTYDILTGAAKGTQVFGQDPLWLAWVTDLVNLKGTDASQYQHLLDTVHPARFKVGQMIGSFGILMGVIVAIYRNVDADKKHKYKGMMIATALATFLTGVTEPIEYMFMFIATPMYLVYSLVQGAAFAMADVVNLRMHSFGSIEFLTRTPIAISAGIGMDIVNFVWVTVLFAVIMYFIANFMIQKFNYATPGRNGNYETAEGSEETSSEVKVAAGSQAVNIINLLGGRVNIVDVDACMTRLRVTVKDADKVGNAEQWKAEGAMGLVMKGQGVQAIYGPKADILKSDIQDILDSGEIIPETLPSQMTEVQQNTVHFKDLTEEVYSVADGQVVALEQVKDPVFAQKMMGDGFAVEPANGNIVSPVSGTVSSIFPTKHAFGIVTEAGLEVLVHIGLDTVSLEGKPFTVHVAEGQKVAAGDLLVTADLNAIRAAGRETSTVVVFTNGDAIKSVKLEKTGSLAAKTAVAKVEL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: CcpA regulon, MalR (repression) regulon
    CcpA(TF)important in Global catabolite repression; RegPrecise 
    MalR(TF)important in Maltose utilization, Maltodextrin utilization; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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