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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
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A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 21-MAR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_RS06245 [old locus tag: SPD_1170 ]
  • pan locus tag?: PNEUPAN000131000
  • symbol: SPD_RS06245
  • pan gene symbol?: appA
  • synonym:
  • product: ABC transporter substrate-binding protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPD_RS06245 [old locus tag: SPD_1170 ]
  • symbol: SPD_RS06245
  • product: ABC transporter substrate-binding protein
  • replicon: chromosome
  • strand: -
  • coordinates: 1198370..1199998
  • length: 1629
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_008533 (1198370..1199998) NCBI
  • BioCyc: G1G6V-1278 BioCyc
  • MicrobesOnline: see SPD_1170
  • PneumoBrowse for strain D39V: SPV_1170 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    ATGAAAAAAATTGTTAAATTAGCTTTAACAGCTGCAGCAGTTTTAATAGCTGTAGTAGGA
    TTGGTTGCTTGTAGTTCGGGAAGCAAAAAATCTGATTTTTCAGAGTCTGGAAAAGAAAAA
    GTATTCTATTTATCAGGTTTTCTTCAAGGAACTGGAGATCGTATCCCTTACGTTTGGCAA
    AATGGTGATGGTTTAGTTCCATATTTGTTATACCGTACACTGTTAATGGCAGATTCAAAA
    TATGAAAAATCAACTCCAGATTTAGCTAAAGATTGGAAAAAATCTGATGATGAAAAAACT
    TATGAATTTACACTTAAAGATGGATTGAAATGGTCTGATGGAGAAGCTTTGACAGCTTCC
    GATGTGGAATTCAGTGTTAAATTAGCATTGAAAGCTTCAGTAATTAATGGAATTTTCCCT
    TCAACATTCACAAAAATTGAAGGAGCTAAAGATTTCAAAGACGATAAAGCAGATAAAATT
    TCTGGTCTTACAGTTGATGGAAATAAAGTAACATTTAAACTTACTGCTCCAGTTGGTGAC
    TTTGAGCAAATGATGACTCAATTCTTTATTCTTCCAAAACATAAATTAGAGTCTGAAAAT
    CCTCTTGAATTAAATAATAGCTCATTTTGGACAGCTCCTGTTACAAGCGGTATGTACAAA
    GTAAAAGAAATTAGTGCAGGTAATTTCTTAGAGTATGACAAAAATGAAAACTATGAAAAT
    GAAAAACCAAAATTTGATAAAGTAGTATTCAACTATATTTCAGATCCAGTTTTAGCATTG
    CAAGATGGTAAATCATACTTCTATTCAACAAACAAACCTCAAGAAATTAGTCAGTTGGAT
    GCTGTATCTACTTTAAGTAAAAAACCAATTGATATCCTATTCTATCGCTACTTTATCGCT
    AACTTAGCAGGTGTCGAAGGTAATGGAGATTCCTTGATTGCTAATCCTAAAGTTAGAGAA
    GCTATTCTATATGCAATTAATCGTGATGAATTAGCTAAATCTGTATTTAGTGGAATTGCA
    GATGTTAATAATACTGGTGTTCCTTCAAGCTTAGAAGCTCATCTGAAATCAGCAAATAAA
    TTTGAATATAATCCAGAAAAAGCAAAACAACTTCTTAAAGAAGCTAAATACGATAATAGC
    AGAAATCTAATTTTAGCTTATTACTATAAAGATCAAGCCTCTCAAGATTTCATGCAAGCA
    GTAAGTTATCAATTGAATGAGGTTGGAATCAAGAACGAAGTTGTCCAAATTACTTCTGAT
    GCAACAACAGGATTGTTCAAAACACGTAAATATGACCTAGCTTATAAAGGATTATCATCA
    TTTGGTTATGAAACTTGGTATGGTGAATATAGTTCAACAAATACTAACTTTAAAAATATT
    ACAAATGGCGAAACAAGTTTTGATGAGTTGAGCAAAAAATTGTCTGAAACTTCTGATGTA
    AAAGAAAGAAACAAAATTTTAGCAAGTCTACAAAAATTAGAACAAGAAAAACTATTGAAG
    TTAAACTTATTCACATTTAAAAACTTCTTGTATTTAAATACTGAAAAAGTTTTAATTCCT
    GACGATGTTCAATTTGGTAATCCATTCTATAAATTTGATTACAAATTCGAAAAATGGGAT
    GCTAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1629

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPD_RS06245 [old locus tag: SPD_1170 ]
  • symbol: SPD_RS06245
  • description: ABC transporter substrate-binding protein
  • length: 542
  • theoretical pI: 5.75707
  • theoretical MW: 61206.9
  • GRAVY: -0.432472

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Cations and iron carrying compounds nickel ABC transporter, nickel/metallophore periplasmic binding protein (TIGR02294; HMM-score: 88.6)
    and 1 more
    Metabolism Transport and binding proteins Unknown substrate ABC transporter substrate binding protein, KPN_01854 family (TIGR04028; HMM-score: 49.5)
  • TheSEED: see SPD_1170
  • PFAM:
    PBP (CL0177) SBP_bac_5; Bacterial extracellular solute-binding proteins, family 5 Middle (PF00496; HMM-score: 217.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0.01
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 9.2
    • Extracellular Score: 0.78
    • Internal Helix: 1
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0.5254
    • Cell wall & surface Score: 0.0046
    • Extracellular Score: 0.47
  • SignalP: Signal peptide LIPO(Sec/SPII) length 23 aa
    • SP(Sec/SPI): 0.001475
    • TAT(Tat/SPI): 0.000168
    • LIPO(Sec/SPII): 0.998014
    • Cleavage Site: CS pos: 23-24. LVA-CS. Pr: 0.9985
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKKIVKLALTAAAVLIAVVGLVACSSGSKKSDFSESGKEKVFYLSGFLQGTGDRIPYVWQNGDGLVPYLLYRTLLMADSKYEKSTPDLAKDWKKSDDEKTYEFTLKDGLKWSDGEALTASDVEFSVKLALKASVINGIFPSTFTKIEGAKDFKDDKADKISGLTVDGNKVTFKLTAPVGDFEQMMTQFFILPKHKLESENPLELNNSSFWTAPVTSGMYKVKEISAGNFLEYDKNENYENEKPKFDKVVFNYISDPVLALQDGKSYFYSTNKPQEISQLDAVSTLSKKPIDILFYRYFIANLAGVEGNGDSLIANPKVREAILYAINRDELAKSVFSGIADVNNTGVPSSLEAHLKSANKFEYNPEKAKQLLKEAKYDNSRNLILAYYYKDQASQDFMQAVSYQLNEVGIKNEVVQITSDATTGLFKTRKYDLAYKGLSSFGYETWYGEYSSTNTNFKNITNGETSFDELSKKLSETSDVKERNKILASLQKLEQEKLLKLNLFTFKNFLYLNTEKVLIPDDVQFGNPFYKFDYKFEKWDAK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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