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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_0121 [new locus tag: SPG_RS00630 ]
  • pan locus tag?: PNEUPAN000790000
  • symbol: pspA
  • pan gene symbol?: pspA
  • synonym:
  • product: pneumococcal surface protein A

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_0121 [new locus tag: SPG_RS00630 ]
  • symbol: pspA
  • product: pneumococcal surface protein A
  • replicon: chromosome
  • strand: +
  • coordinates: 123363..125492
  • length: 2130
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    ATGAATAAGAAAAAAATGATTTTAACAAGTCTAGCCAGCGTCGCTATCTTAGGGGCTGGT
    TTTGTTGCGTCTCAGCCTACTGTTGTAAGAGCAGAAGCCGCTCCACAAGTTGTCGAAAAA
    TCTTCATTAGAGAAGAAATATGAGGAAGCAAAAGCAAAAGCTGATACTGCCAAGAAAGAT
    TACGAAACGGCTAAAAAGAAAGCAGCAGAAGCTCAGAAAAAGTATGAAGATGATCAGAAG
    AGAACTGAGGAGAAAGGCGCGCTAGAAGAAGAAACTTCTAGGAAGGTAAACGATGCTACT
    TTAGAGGTACAAAACGCATATGTAGAATATGGAGAAGCTAATAAGAAAAAAGGTAAGGAC
    CGTGAGAAAAAATTAGCAGATGCGCAAAAAAAAATAGATGAAGCGCAGGAAAAACTAACC
    AAAGCTAAAAATGAGTTTCAATCTGTTCGAGCAATGGTAGTTCCTGAGCCAGAGCAGTTG
    GCTGAGACTAAGAAAAAAGCAGAAGAAGCTAAAGCAGAAGAGGCAGTGGCTAAGGAAAAA
    TCTGATAAGGCAGCTAAAGAGGTAGAAGTAGCGAAAAAAAGAGTAGAGGCAGAAGAAGCT
    GAGTTGGATAAAAAAGTTGCTGAACTTCAAAATAAAGTTGCTGATTTAGAAAAAGAAATA
    GCTGATGCTGAAAAAACGGTAGCAGATTTAGAAAAAGAAGTTGCTAAACTTGAAAAAGAT
    GTAGAAGATTTCAAAAACTCAAACGGTGAGCAAGCTGAACAATACCTTGCTGCAGCTGAA
    AAAGACTTAGTTGCTAAAAAAGCTGAATTAGCAGAAGCTAAAATTAAAGCTGCTACTAAA
    AAAGCTGAATTAGAACCTGAATTAGAAAAAGCAGAAGCTGAACTTGAAAACCTATTATCT
    ACACTAGACCCTGAAGGTAAGACTCAGGATGAATTAGATAAAGAAGCTGCTGAAGCTGAG
    TTGAATAAAAAAGTTGAAGCTCTTCAAAACCAAGTTGCTGAATTAGAAGAAGAACTTTCA
    AAACTTGAAGATAATCTTAAAGATGCTGAAACAAACAACGTTGAAGACTACATTAAAGAA
    GGTTTAGAAGAAGCTATCGCGACTAAAAAAGCTGAATTGGAAAAAACTCAAAAAGAATTA
    GATGCAGCTCTTAATGAGTTAGGCCCTGATGGAGATGAAGAAGAGACTCCAGCGCCGGCT
    CCTCAACCAGAAAAACCAGCTCCAGCTCCTGCACCAAAACCAGAGCAACCAGCTCCAGCA
    CCAAAACCAGAAAAAACAGATGATCAACAAGCTGAAGAAGACTATGCTCGTAGATCAGAA
    GAAGAATATAACCGCTTGCCCCAACAGCAACCGCCAAAAGCAGAAAAACCAGCTCCAGCA
    CCAAAACCAGAGCAACCAGTTCCTGCACCAAAAACAGGTTGGAAACAAGAAAACGGTATG
    TGGTACTTCTACAATACTGATGGTTCAATGGCTACAGGTTGGCTCCAAAACAACGGTTCA
    TGGTACTACCTCAACAGCAATGGCGCTATGGCTACAGGTTGGCTCCAATACAATGGTTCA
    TGGTATTACCTAAACGCTAACGGCGCTATGGCTACAGGTTGGGCTAAAGTCAACGGTTCA
    TGGTACTACCTCAACGCTAATGGTGCTATGGCTACAGGTTGGCTCCAATACAACGATTCA
    TGGTATTACCTAAACGCTAACGGCGCTATGGCGACAGGATGGCTCCAATACAACGGTTCA
    TGGTACTACCTCAACGCTAACGGTGCTATGGCTACAGGTTGGGCTAAAGTCAACGGTTCA
    TGGTACTACCTCAACGCTAATGGTGCTATGGCTACAGGTTGGCTCCAATACAACGGTTCA
    TGGTACTACCTAAACGCTAACGGTGCTATGGCTACAGGTTGGGCTAAAGTCAACGGTTCA
    TGGTACTACCTCAACGCTAACGGTTCAATGGCAACAGGTTGGGTGAAAGATGGAGATACC
    TGGTACTATCTTGAAGCATCAGGTGCTATGAAAGCAAGCCAATGGTTCAAAGTATCAGAT
    AAATGGTACTATGTCAATGGTTTAGGTGCCCTTGCAGTCAACACAACTGTAGATGGCTAT
    AAAGTCAATGCCAATGGTGAATGGGTTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2130

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_0121 [new locus tag: SPG_RS00630 ]
  • symbol: PspA
  • description: pneumococcal surface protein A
  • length: 709
  • theoretical pI: 4.5289
  • theoretical MW: 78717.9
  • GRAVY: -0.891537

⊟Function[edit | edit source]

  • TIGRFAM:
    glucan-binding repeat (TIGR04035; HMM-score: 83.2)
    and 9 more
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02168; HMM-score: 28.5)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02168; HMM-score: 28.5)
    Cellular processes Cellular processes Cell division chromosome segregation protein SMC (TIGR02169; HMM-score: 21.1)
    Genetic information processing DNA metabolism Chromosome-associated proteins chromosome segregation protein SMC (TIGR02169; HMM-score: 21.1)
    helix-rich protein (TIGR04523; HMM-score: 16.5)
    SEC10/PgrA surface exclusion domain (TIGR04320; HMM-score: 16.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin ATP:cob(I)alamin adenosyltransferase (TIGR00636; EC 2.5.1.17; HMM-score: 7.2)
    Hypothetical proteins Conserved TIGR02680 family protein (TIGR02680; HMM-score: 7)
    WXG100 family type VII secretion target (TIGR03930; HMM-score: 4.9)
  • TheSEED  :
    • Choline binding protein A
    Stress Response Osmotic stress Choline and Betaine Uptake and Betaine Biosynthesis  Choline binding protein A
  • PFAM:
    Choline_binding (CL0694) Choline_bind_1; Putative cell wall binding repeat (PF01473; HMM-score: 229.7)
    Choline_bind_3; Choline-binding repeat (PF19127; HMM-score: 209.4)
    and 19 more
    Choline_bind_2; Choline-binding repeat (PF19085; HMM-score: 54)
    no clan defined FlaC_arch; Flagella accessory protein C (FlaC) (PF05377; HMM-score: 17.3)
    SlyX; SlyX (PF04102; HMM-score: 16.8)
    DUF3287; Protein of unknown function (DUF3287) (PF11690; HMM-score: 16.4)
    MscS_porin; Mechanosensitive ion channel porin domain (PF12795; HMM-score: 16.1)
    DUF5082; Domain of unknown function (DUF5082) (PF16888; HMM-score: 15.7)
    TMF_DNA_bd; TATA element modulatory factor 1 DNA binding (PF12329; HMM-score: 15.5)
    NPV_P10; Nucleopolyhedrovirus P10 protein (PF05531; HMM-score: 15.2)
    DUF4407; Domain of unknown function (DUF4407) (PF14362; HMM-score: 14.1)
    MbeD_MobD; MbeD/MobD like (PF04899; HMM-score: 13.6)
    Pox_A_type_inc; Viral A-type inclusion protein repeat (PF04508; HMM-score: 13.5)
    Baculo_PEP_C; Baculovirus polyhedron envelope protein, PEP, C terminus (PF04513; HMM-score: 11.7)
    HSBP1; Heat shock factor binding protein 1 (PF06825; HMM-score: 10.9)
    DASH_Hsk3; DASH complex subunit Hsk3 like (PF08227; HMM-score: 10.9)
    4H_Cytokine (CL0053) IL11; Interleukin 11 (PF07400; HMM-score: 8.9)
    no clan defined TRAF_BIRC3_bd; TNF receptor-associated factor BIRC3 binding domain (PF16673; HMM-score: 8.4)
    Myosin_tail_1; Myosin tail (PF01576; HMM-score: 8.1)
    TolA_bind_tri; TolA binding protein trimerisation (PF16331; HMM-score: 7)
    DASH_Dam1; DASH complex subunit Dam1 (PF08653; HMM-score: 6.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Extracellular
    • Cytoplasmic Score: 0.01
    • Cytoplasmic Membrane Score: 0.09
    • Cellwall Score: 0.18
    • Extracellular Score: 9.72
    • Internal Helices: 0
  • DeepLocPro: Cell wall & surface
    • Cytoplasmic Score: 0.0019
    • Cytoplasmic Membrane Score: 0.0002
    • Cell wall & surface Score: 0.8901
    • Extracellular Score: 0.1078
  • SignalP: Signal peptide SP(Sec/SPI) length 33 aa
    • SP(Sec/SPI): 0.985292
    • TAT(Tat/SPI): 0.011178
    • LIPO(Sec/SPII): 0.002802
    • Cleavage Site: CS pos: 33-34. AEA-AP. Pr: 0.5765
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACF54852 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNKKKMILTSLASVAILGAGFVASQPTVVRAEAAPQVVEKSSLEKKYEEAKAKADTAKKDYETAKKKAAEAQKKYEDDQKRTEEKGALEEETSRKVNDATLEVQNAYVEYGEANKKKGKDREKKLADAQKKIDEAQEKLTKAKNEFQSVRAMVVPEPEQLAETKKKAEEAKAEEAVAKEKSDKAAKEVEVAKKRVEAEEAELDKKVAELQNKVADLEKEIADAEKTVADLEKEVAKLEKDVEDFKNSNGEQAEQYLAAAEKDLVAKKAELAEAKIKAATKKAELEPELEKAEAELENLLSTLDPEGKTQDELDKEAAEAELNKKVEALQNQVAELEEELSKLEDNLKDAETNNVEDYIKEGLEEAIATKKAELEKTQKELDAALNELGPDGDEEETPAPAPQPEKPAPAPAPKPEQPAPAPKPEKTDDQQAEEDYARRSEEEYNRLPQQQPPKAEKPAPAPKPEQPVPAPKTGWKQENGMWYFYNTDGSMATGWLQNNGSWYYLNSNGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYLNANGAMATGWLQYNDSWYYLNANGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYLNANGAMATGWLQYNGSWYYLNANGAMATGWAKVNGSWYYLNANGSMATGWVKDGDTWYYLEASGAMKASQWFKVSDKWYYVNGLGALAVNTTVDGYKVNANGEWV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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