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TIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_0824
  • pan locus tag?:
  • symbol: SPG_0824
  • pan gene symbol?: —
  • synonym:
  • product: pyruvate kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_0824
  • symbol: SPG_0824
  • product: pyruvate kinase
  • replicon: chromosome
  • strand: +
  • coordinates: 802133..803083
  • length: 951
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: CP001015 (802133..803083) NCBI
  • BioCyc:
  • MicrobesOnline: 5756093 MicrobesOnline
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    GTGAACATCCCTAACACTAAAATTCCTTTCCCAGCTCTTGCTGAACGCGATAACGACGAT
    ATCCGTTTCGGTCTTGAACAAGGTATCAACTTCATCGCAATTTCATTCGTACGTACTGCA
    AAAGATGTGAACGAAGTTCGTGCAATCTGTGAAGAAACTGGAAACGGACATGTTCAATTG
    TTCGCTNAAATCGAAAACCAACAAGGTATCGATAACTTAGACGAAATCATCGAAGCAGCT
    GATGGTATTATGATTGCTCGTGGTGATATGGGTATCGAAGTACCGTTCGAAATGGTTCCA
    GTTTATCAAAAAATGATTATCAAGAAAGTCAATGCTGCAGGTAAAGTTGTTATCACTGCA
    ACAAACATGCTTGAAACAATGACTGAAAAACCACGTGCAACTCGTTCAGAAGTATCAGAC
    GTATTCAACGCTGTTATCGACGGAACTGACGCTACAATGCTGTCAGGCGAGTCTGCAAAC
    GGTAAATACCCACTCGAGTCAGTAACTACAATGGCTACAATCGACAAGAACGCTCAAGCT
    CTTCTTAATGAATACGGACGTCTTGATTCAGATTCATTTGAGCGTAACTCTAAGACAGAA
    GTAATGGCTTCTGCTGTTAAAGATGCTACTAGCTCAATGGATATCAAATTGGTTGTAACT
    CTTACTAAGACAGGTCATACTGCACGTTTGATTTCTAAATACCGTCCAAATGCTGACATC
    TTAGCATTGACATTTGACGAATTGACAGAACGTGGCTTGATGTTGAACTGGGGTGTTATC
    CCAATGTTGACAGATGCTCCATCTTCAACTGACGATATGTTCGAAATCGCTGAACGTAAA
    GCGGTAGAAGCAGGTCTCGTTGAGTCAGGCGATGATATCGTTATCGTTGCTGGTGTGCCA
    GTAGGAGAAGCTGTTCGCACAAACACAATGCGTATCCGCACAGTACGTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    951

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_0824
  • symbol: SPG_0824
  • description: pyruvate kinase
  • length: 316
  • theoretical pI: 4.39967
  • theoretical MW: 34379
  • GRAVY: -0.0965079

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.1.40?  ExPASy
    Pyruvate kinase ATP + pyruvate = ADP + phosphoenolpyruvate
  • TIGRFAM:
    Metabolism Energy metabolism Glycolysis/gluconeogenesis pyruvate kinase (TIGR01064; EC 2.7.1.40; HMM-score: 367)
    and 3 more
    2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase (TIGR02311; EC 4.1.2.-; HMM-score: 18.4)
    2-dehydro-3-deoxyglucarate aldolase (TIGR03239; EC 4.1.2.20; HMM-score: 13.6)
    polysaccharide export protein EpsE (TIGR03028; HMM-score: 12.3)
  • TheSEED  :
    • Pyruvate kinase (EC 2.7.1.40)
    Carbohydrates Central carbohydrate metabolism Entner-Doudoroff Pathway  Pyruvate kinase (EC 2.7.1.40)
    and 4 more
    Carbohydrates Central carbohydrate metabolism Glycolysis and Gluconeogenesis  Pyruvate kinase (EC 2.7.1.40)
    Carbohydrates Central carbohydrate metabolism Pyruvate metabolism I: anaplerotic reactions, PEP  Pyruvate kinase (EC 2.7.1.40)
    Carbohydrates Fermentation Fermentations: Mixed acid  Pyruvate kinase (EC 2.7.1.40)
    Carbohydrates Organic acids Glycerate metabolism  Pyruvate kinase (EC 2.7.1.40)
  • PFAM:
    PK_TIM (CL0151) PK; Pyruvate kinase, barrel domain (PF00224; HMM-score: 306.4)
    and 3 more
    no clan defined PK_C; Pyruvate kinase, alpha/beta domain (PF02887; HMM-score: 113.6)
    PK_TIM (CL0151) HpcH_HpaI; HpcH/HpaI aldolase/citrate lyase family (PF03328; HMM-score: 32.6)
    no clan defined RME-8_N; DNAJ protein RME-8 N-terminal (PF19432; HMM-score: 11.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007563
    • TAT(Tat/SPI): 0.000599
    • LIPO(Sec/SPII): 0.000679
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACF55872 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNIPNTKIPFPALAERDNDDIRFGLEQGINFIAISFVRTAKDVNEVRAICEETGNGHVQLFAXIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIIKKVNAAGKVVITATNMLETMTEKPRATRSEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATIDKNAQALLNEYGRLDSDSFERNSKTEVMASAVKDATSSMDIKLVVTLTKTGHTARLISKYRPNADILALTFDELTERGLMLNWGVIPMLTDAPSSTDDMFEIAERKAVEAGLVESGDDIVIVAGVPVGEAVRTNTMRIRTVR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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