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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_1384 [new locus tag: SPG_RS06910 ]
  • pan locus tag?: PNEUPAN002782000
  • symbol: trxB
  • pan gene symbol?: trxB
  • synonym:
  • product: thioredoxin reductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_1384 [new locus tag: SPG_RS06910 ]
  • symbol: trxB
  • product: thioredoxin reductase
  • replicon: chromosome
  • strand: -
  • coordinates: 1343390..1344301
  • length: 912
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGTACGATACTATTATTATCGGTGCTGGACCTGCAGGGATGACTGCGGCCTTGTATGCT
    GCTCGAAGCAATCTAAAAGTAGCTTTGATTGAAGGTGGTCTGCCAGGTGGTCAGATGAAT
    AATACATCTGATATCGAAAATTACCCAGGATACGCTAATATTAGTGGACCTGAATTGGCT
    GAAAAGATGTTTGAACCACTTGAAAATCTTGGTGTTGAGCACATTTATGGTTATGTTGAA
    AATGTCGAAGACCATGGTGATTTTAAGAAAGTGATGACTGATGACCAAACATATGAAACA
    CGTACAGTTATCGTAGCAACTGGTTCTAAACACCGTCCTTTGGGAGTGCCTGGAGAAGAA
    GAACTGAACAGTCGTGGTGTTTCTTACTGTGCTGTGTGTGATGGTGCTTTCTTCCGTGAC
    CAAGATTTATTGGTAGTTGGTGGTGGAGATTCAGCTGTTGAAGAAGCCCTCTTCTTGACT
    CGTTTTGCTAAGACTGTTACCATTGTTCACCGTCGTGACCAACTTCGTGCCCAAAAGGTT
    TTACAAGATCGCGCCTTTGCGAATGAAAAAATCAGCTTTATCTGGGATTCTGTAGTAAGG
    GAAATCAAGGGTGAAAACCGAGTAGAATCAGTCGTATTTGAAAATGTGAAAACAGGTCAA
    GTGACAGAACAAGCCTTCGGTGGTGTCTTTATCTATGTTGGTTTGGACCCTCTTAGCGAT
    TTTGTTAAAGAATTGAATATCCAAGATCAGGCAGGATGGATTGTGACAGATAACCACATG
    AAAACTGCAGTCGACGGTATCTTTGCAGTTGGAGATGTTCGCTTGAAAGACCTTCGCCAA
    GTAACAACAGCGGTTGGAGATGGAGCTATCGCTGGTCAAGAAGCCTATAAATTCATTACA
    GAACATAGTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    912

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_1384 [new locus tag: SPG_RS06910 ]
  • symbol: TrxB
  • description: thioredoxin reductase
  • length: 303
  • theoretical pI: 4.50525
  • theoretical MW: 33147
  • GRAVY: -0.165677

⊟Function[edit | edit source]

  • reaction:
    EC 1.8.1.9?  ExPASy
    Thioredoxin-disulfide reductase Thioredoxin + NADP+ = thioredoxin disulfide + NADPH
  • TIGRFAM:
    Metabolism Energy metabolism Electron transport thioredoxin-disulfide reductase (TIGR01292; EC 1.8.1.9; HMM-score: 390.1)
    putative alkyl hydroperoxide reductase F subunit (TIGR03143; EC 1.6.4.-; HMM-score: 323.2)
    and 46 more
    Cellular processes Cellular processes Detoxification alkyl hydroperoxide reductase subunit F (TIGR03140; EC 1.8.1.-; HMM-score: 243)
    Cellular processes Cellular processes Adaptations to atypical conditions alkyl hydroperoxide reductase subunit F (TIGR03140; EC 1.8.1.-; HMM-score: 243)
    Unknown function Enzymes of unknown specificity putative bacillithiol system oxidoreductase, YpdA family (TIGR04018; EC 1.8.-.-; HMM-score: 96.4)
    dihydrolipoyl dehydrogenase (TIGR01350; EC 1.8.1.4; HMM-score: 93.5)
    Cellular processes Cellular processes Detoxification mercury(II) reductase (TIGR02053; EC 1.16.1.1; HMM-score: 70.4)
    thioredoxin and glutathione reductase (TIGR01438; EC 1.6.4.-; HMM-score: 54.8)
    Cellular processes Cellular processes Detoxification CoA-disulfide reductase (TIGR03385; EC 1.8.1.14; HMM-score: 53.1)
    Metabolism Energy metabolism Electron transport glutathione-disulfide reductase (TIGR01421; EC 1.8.1.7; HMM-score: 47.1)
    Metabolism Energy metabolism Electron transport glutathione-disulfide reductase (TIGR01424; EC 1.8.1.7; HMM-score: 46)
    putative selenate reductase, YgfK subunit (TIGR03315; HMM-score: 41.4)
    Unknown function Enzymes of unknown specificity flavoprotein, HI0933 family (TIGR00275; HMM-score: 40.9)
    mycofactocin system FadH/OYE family oxidoreductase 2 (TIGR03997; EC 1.-.-.-; HMM-score: 40.1)
    Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, alpha subunit family (TIGR01372; HMM-score: 35.9)
    Metabolism Amino acid biosynthesis Glutamate family glutamate synthase (NADPH), homotetrameric (TIGR01316; EC 1.4.1.13; HMM-score: 35.7)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll geranylgeranyl reductase family (TIGR02032; EC 1.3.1.-; HMM-score: 33.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine thiazole biosynthesis enzyme (TIGR00292; HMM-score: 31.9)
    mycofactocin system FadH/OYE family oxidoreductase 1 (TIGR03996; EC 1.-.-.-; HMM-score: 29.1)
    mycothione reductase (TIGR03452; EC 1.8.1.15; HMM-score: 28)
    lycopene cyclase family protein (TIGR01790; HMM-score: 27.3)
    Metabolism Central intermediary metabolism Nitrogen metabolism nitrite reductase [NAD(P)H], large subunit (TIGR02374; EC 1.7.1.4; HMM-score: 26.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family (TIGR01988; EC 1.14.13.-; HMM-score: 22.5)
    trypanothione-disulfide reductase (TIGR01423; EC 1.8.1.12; HMM-score: 22.3)
    pyridine nucleotide-disulfide oxidoreductase family protein (TIGR03169; HMM-score: 21.8)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA (TIGR00136; HMM-score: 21)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine glycine oxidase ThiO (TIGR02352; EC 1.4.3.19; HMM-score: 20.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridine nucleotides L-aspartate oxidase (TIGR00551; EC 1.4.3.16; HMM-score: 19.4)
    flavin-dependent oxidoreductase, MSMEG_0569 family (TIGR04046; HMM-score: 19.4)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 2-polyprenyl-6-methoxyphenol 4-hydroxylase (TIGR01984; EC 1.14.13.-; HMM-score: 18.6)
    Metabolism Energy metabolism TCA cycle succinate dehydrogenase, flavoprotein subunit (TIGR01816; HMM-score: 18.2)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Chlorophyll and bacteriochlorphyll geranylgeranyl reductase (TIGR02023; EC 1.3.1.-; HMM-score: 17.7)
    Metabolism Energy metabolism TCA cycle succinate dehydrogenase or fumarate reductase, flavoprotein subunit (TIGR01812; HMM-score: 17.4)
    Metabolism Energy metabolism Anaerobic succinate dehydrogenase or fumarate reductase, flavoprotein subunit (TIGR01812; HMM-score: 17.4)
    Metabolism Energy metabolism Aerobic succinate dehydrogenase or fumarate reductase, flavoprotein subunit (TIGR01812; HMM-score: 17.4)
    Metabolism Energy metabolism Anaerobic glycerol-3-phosphate dehydrogenase, anaerobic, B subunit (TIGR03378; EC 1.1.5.3; HMM-score: 17.2)
    squalene-associated FAD-dependent desaturase (TIGR03467; HMM-score: 16)
    Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, beta subunit family (TIGR01373; HMM-score: 15.4)
    glutamate synthase, small subunit (TIGR01318; HMM-score: 15.3)
    glutamate synthase, NADH/NADPH, small subunit (TIGR01317; EC 1.4.1.-; HMM-score: 15)
    Metabolism Energy metabolism Amino acids and amines sarcosine oxidase, monomeric form (TIGR01377; HMM-score: 15)
    fumarate reductase (quinol), flavoprotein subunit (TIGR01176; EC 1.3.5.4; HMM-score: 14.4)
    FAD dependent oxidoreductase TIGR03364 (TIGR03364; HMM-score: 14.4)
    Metabolism Energy metabolism Electron transport flavocytochrome c (TIGR01813; HMM-score: 13.3)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides UDP-galactopyranose mutase (TIGR00031; EC 5.4.99.9; HMM-score: 12.9)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain (TIGR03197; HMM-score: 12.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other phytoene desaturase (TIGR02734; EC 1.14.99.-; HMM-score: 12)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin precorrin 3B synthase CobZ (TIGR02485; HMM-score: 11.7)
  • TheSEED  :
    • Thioredoxin reductase (EC 1.8.1.9)
    Nucleosides and Nucleotides Pyrimidines pyrimidine conversions  Thioredoxin reductase (EC 1.8.1.9)
    and 1 more
    Sulfur Metabolism Sulfur Metabolism - no subcategory Thioredoxin-disulfide reductase  Thioredoxin reductase (EC 1.8.1.9)
  • PFAM:
    NADP_Rossmann (CL0063) Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase (PF07992; HMM-score: 166.5)
    and 16 more
    Pyr_redox_3; Pyridine nucleotide-disulphide oxidoreductase (PF13738; HMM-score: 98.4)
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase (PF00070; HMM-score: 77.8)
    DAO; FAD dependent oxidoreductase (PF01266; HMM-score: 44.5)
    FAD_oxidored; FAD dependent oxidoreductase (PF12831; HMM-score: 37.1)
    GIDA; Glucose inhibited division protein A (PF01134; HMM-score: 36.2)
    FAD_binding_2; FAD binding domain (PF00890; HMM-score: 36.1)
    HI0933_like; HI0933-like protein (PF03486; HMM-score: 33.2)
    Lycopene_cycl; Lycopene cyclase protein (PF05834; HMM-score: 30.9)
    Thi4; Thi4 family (PF01946; HMM-score: 29.3)
    NAD_binding_8; NAD(P)-binding Rossmann-like domain (PF13450; HMM-score: 27)
    NAD_binding_7; Putative NAD(P)-binding (PF13241; HMM-score: 20)
    NAD_binding_9; FAD-NAD(P)-binding (PF13454; HMM-score: 19.9)
    Lys_Orn_oxgnase; L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase (PF13434; HMM-score: 17.8)
    FAD_binding_3; FAD binding domain (PF01494; HMM-score: 17.7)
    Trp_halogenase; Tryptophan halogenase (PF04820; HMM-score: 11.6)
    AlaDh_PNT_C; Alanine dehydrogenase/PNT, C-terminal domain (PF01262; HMM-score: 10.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.123075
    • TAT(Tat/SPI): 0.022348
    • LIPO(Sec/SPII): 0.052237
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACF56820 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MYDTIIIGAGPAGMTAALYAARSNLKVALIEGGLPGGQMNNTSDIENYPGYANISGPELAEKMFEPLENLGVEHIYGYVENVEDHGDFKKVMTDDQTYETRTVIVATGSKHRPLGVPGEEELNSRGVSYCAVCDGAFFRDQDLLVVGGGDSAVEEALFLTRFAKTVTIVHRRDQLRAQKVLQDRAFANEKISFIWDSVVREIKGENRVESVVFENVKTGQVTEQAFGGVFIYVGLDPLSDFVKELNIQDQAGWIVTDNHMKTAVDGIFAVGDVRLKDLRQVTTAVGDGAIAGQEAYKFITEHS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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