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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_2098 [new locus tag: SPG_RS10490 ]
  • pan locus tag?: PNEUPAN003819000
  • symbol: SPG_2098
  • pan gene symbol?: fucI
  • synonym:
  • product: L-fucose isomerase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_2098 [new locus tag: SPG_RS10490 ]
  • symbol: SPG_2098
  • product: L-fucose isomerase
  • replicon: chromosome
  • strand: -
  • coordinates: 1986365..1987879
  • length: 1515
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    ATGATTCAACATCCACGTATTGGTATTCGTCCGACTATTGATGGTCGTCGTCAAGGTGTA
    CGCGAATCACTTGAAGTGCAAACAATGAACATGGCTAAAAGTGTGGCAGATTTGATTTCA
    AGCACATTGAAATATCCAGATGGGGAACCTGTGGAATGTGTGATTTCTCCATCTACCATT
    GGTCGTGTTCCAGAGGCTGCAGCTTCCCATGAGTTGTTTAAAAAATCAAATGTTTGCGCA
    ACAATTACAGTTACACCATGCTGGTGTTATGGTAGTGAAACTATGGATATGTCTCCAGAT
    ATTCCTCATGCTATTTGGGGATTTAATGGGACAGAACGCCCAGGAGCTGTCTATCTTGCA
    GCTGTACTAGCTTCACATGCTCAAAAAGGGATTCCAGCCTTTGGGATTTATGGTAGAGAT
    GTTCAGGAAGCTAATGATACAGATATTCCAGAAGATGTCAAAGAAAAACTTTTACGTTAT
    GCGCGTGCAGCTCTTGCAACTGGCTTGATGAGAGACACTGCTTACCTATCAATGGGTAGT
    GTTTCGATGGGGATTGGTGGTTCTATTGTAAATCCAGATTTCTTCCAAGAATACTTAGGA
    ATGCGAAATGAATCGGTAGATATGACGGAGTTCACACGCCGTATGGACCGTGGTATTTAC
    GACCCTGAAGAGTTCGAACGTGCGCTCAAATGGGTGAAAGAAAACGTAAAAGAAGGATTC
    GACCATAACCGTGAAGACCTTGTTTTAAGCCGTGAAGAAAAAGATAGACAATGGGAATTT
    GTTATTAAGATGTTCATGATTGGACGTGACTTAATGGTTGGTAACCCAAGACTTGCTGAA
    CTTGGTTTTGAGGAAGAAGCAGTTGGTCACCATGCTTTAGTAGCTGGTTTCCAAGGTCAA
    CGCCAGTGGACAGACCATTTTCCAAATGGTGACTTTATGGAAACTTTCCTCAATACTCAG
    TTTGACTGGAATGGTATTCGAAAACCATTTGTATTTGCGACAGAGAATGATTCACTAAAT
    GGTGTGTCTATGCTCTTTAATTATCTATTAACAAATACTCCACAAATCTTTGCTGATGTG
    CGTACTTATTGGAGCCCAGAGGCTGTTAAACGTGTAACGGGACATACTTTAGAGGGTCGT
    GCTGCAGCTGGCTTCTTACATCTAATCAACTCTGGTTCTTGTACATTGGATGGTACAGGT
    CAAGCTACTCGAGATGGCAAACCTATTATGAAACCATTCTGGGAGTTGGAAGAAAGTGAA
    GTGCAGGCTATGCTTGAAAATACAGACTTCCCACCAGCAAACCGCGAATACTTCCGTGGA
    GGAGGATTCTCAACTCGTTTCTTGACGAAGGGGGATATGCCAGTAACAATGGTACGTCTC
    AATCTTCTAAAAGGGGTTGGTCCAGTGCTACAAATTGCAGAAGGTTACACACTTGAACTT
    CCTGAAGATGTTCACCATACTTTAGATAATCGTACAGATCCAGGATGGCCAATACTTGGT
    TTGCTCCACGTTTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1515

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_2098 [new locus tag: SPG_RS10490 ]
  • symbol: SPG_2098
  • description: L-fucose isomerase
  • length: 504
  • theoretical pI: 4.95563
  • theoretical MW: 56496.7
  • GRAVY: -0.326389

⊟Function[edit | edit source]

  • reaction:
    EC 5.3.1.25?  ExPASy
    L-fucose isomerase L-fucopyranose = L-fuculose
  • TIGRFAM:
    Metabolism Energy metabolism Sugars L-fucose isomerase (TIGR01089; EC 5.3.1.25; HMM-score: 831.7)
    and 1 more
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides dTDP-4-dehydrorhamnose 3,5-epimerase (TIGR01221; EC 5.1.3.13; HMM-score: 13.9)
  • TheSEED  :
    • L-fucose isomerase (EC 5.3.1.25)
  • PFAM:
    no clan defined Fucose_iso_N2; L-fucose isomerase, second N-terminal domain (PF07882; HMM-score: 309.6)
    Fucose_iso_N1; L-fucose isomerase, first N-terminal domain (PF07881; HMM-score: 266.8)
    and 1 more
    FucI-AraA_C (CL0393) Fucose_iso_C; L-fucose isomerase, C-terminal domain (PF02952; HMM-score: 104.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.012529
    • TAT(Tat/SPI): 0.004975
    • LIPO(Sec/SPII): 0.002296
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACF55517 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MIQHPRIGIRPTIDGRRQGVRESLEVQTMNMAKSVADLISSTLKYPDGEPVECVISPSTIGRVPEAAASHELFKKSNVCATITVTPCWCYGSETMDMSPDIPHAIWGFNGTERPGAVYLAAVLASHAQKGIPAFGIYGRDVQEANDTDIPEDVKEKLLRYARAALATGLMRDTAYLSMGSVSMGIGGSIVNPDFFQEYLGMRNESVDMTEFTRRMDRGIYDPEEFERALKWVKENVKEGFDHNREDLVLSREEKDRQWEFVIKMFMIGRDLMVGNPRLAELGFEEEAVGHHALVAGFQGQRQWTDHFPNGDFMETFLNTQFDWNGIRKPFVFATENDSLNGVSMLFNYLLTNTPQIFADVRTYWSPEAVKRVTGHTLEGRAAAGFLHLINSGSCTLDGTGQATRDGKPIMKPFWELEESEVQAMLENTDFPPANREYFRGGGFSTRFLTKGDMPVTMVRLNLLKGVGPVLQIAEGYTLELPEDVHHTLDNRTDPGWPILGLLHV

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: CcpA* regulon, FucR* (repression) regulon
    CcpA*(TF)important in Global catabolite repression; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 
    FucR*(TF)important in Fucose utilization; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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