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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 30-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_2127 [new locus tag: SPG_RS10620 ]
  • pan locus tag?: PNEUPAN003852000
  • symbol: glpK
  • pan gene symbol?: glpK
  • synonym:
  • product: glycerol kinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_2127 [new locus tag: SPG_RS10620 ]
  • symbol: glpK
  • product: glycerol kinase
  • replicon: chromosome
  • strand: -
  • coordinates: 2019680..2021188
  • length: 1509
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    ATGTCACAAGAAAAATACATCATGGCCATTGACCAGGGAACTACAAGTTCTCGTGCCATC
    ATTTTCAACAAAAAAGGGGAAAAGGTTAGCTCGAGTCAAAAAGAGTTTACCCAGATTTTC
    CCTCAGGCAGGTTGGGTTGAGCACAATGCCAATGAAATTTGGAACTCTGTTCAGTCAGTT
    ATTGCGGGTGCTTTCATCGAAAGTGGTGTCAAGCCAAATCAAATCGAGGCAATCGGGATT
    ACCAACCAACGTGAAACAACGGTTGTCTGGGATAAGAAAACAGGACTTCCTATCTACAAT
    GCTATCGTTTGGCAGTCACGCCAGACAGCACCTTTGGCTGAGCAACTAAAAAGCCAAGGT
    TATGTGGAAAAATTCCATGAAAAGACTGGTTTGATTATTGATGCTTACTTCTCTGCTACC
    AAGGTTCGTTGGATTTTGGATCATGTAGAAGATGCTCAAGAGCGAGCAGAAAAAGGGGAA
    TTGCTCTTTGGTACTATCGATACTTGGTTGGTTTGGAAATTGACTGACGGTGCGGCTCAC
    GTGACTGACTACTCAAATGCAGCTCGTACCATGCTTTATAACATTAAAGAACTCAAATGG
    GATGATGAGATTTTGGAAATCCTTAACATTCCGAAGGCTATACTTCCAGAAGTTCGTTCT
    AACTCCGAAATCTACGGCAAGACAGCTCCATTCCATTTCTACGGTGGAGAGGTGCCAATC
    TCAGGTATGGCTGGGGACCAACAAGCAGCCCTCTTTGGACAGTTGGCTTTTGAGCCAGGT
    ATGGTTAAGAATACTTATGGAACAGGCTCTTTCATCATCATGAATACTGGGGAAGAGATG
    CAGTTGTCTGAAAACAACCTCTTGACAACCATTGGTTACGGAATCAACGGTAAGGTTTAT
    TATGCCTTGGAAGGTTCTATCTTCATCGCAGGAAGTGCTATTCAGTGGCTTCGTGACGGT
    CTTCGCATGGTTGAAAATTCACCAGAATCTGAAAAATACGCTCGTGATTCTCACAACAAC
    GATGAAGTTTATGTCGTTCCAGCCTTTACAGGTCTAGGCGCTCCATACTGGAACCAAAAT
    GCTCGTGGTTCCGTCTTTGGTTTGACTCGTGGAACAAGCAAAGAAGACTTTATCAAGGCG
    ACTTTGCAATCTATTGCTTATCAAGTGCGTGACATCATCGACACTATGCAAGTGGATACT
    CAGACTGCCATTCAAGTACTGAAGGTGGATGGTGGTGCAGCCATGAACAACTTCCTCATG
    CAGTTCCAGGCGGATATTTTAGGCATTGACATTGCACGTGCTAAAAACTTGGAAACAACA
    GCTCTAGGAGCGGCCTTCCTAGCAGGTTTGTCAGTAGGGTACTGGAAAGACTTGGACGAG
    TTGAAACTCTTGAACGAGACAGGAGAACTCTTTGAGCCATCTATGAATGAATCTCGCAAG
    GAACAACTCTACAAGGGCTGGAAGAAGGCTGTGAAAGCAACTCAAGTCTTTGCGGAAGTA
    GACGACTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1509

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_2127 [new locus tag: SPG_RS10620 ]
  • symbol: GlpK
  • description: glycerol kinase
  • length: 502
  • theoretical pI: 4.7107
  • theoretical MW: 55907.8
  • GRAVY: -0.261355

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.1.30?  ExPASy
    Glycerol kinase ATP + glycerol = ADP + sn-glycerol 3-phosphate
  • TIGRFAM:
    Metabolism Energy metabolism Other glycerol kinase (TIGR01311; EC 2.7.1.30; HMM-score: 738.4)
    and 8 more
    Metabolism Energy metabolism Sugars xylulokinase (TIGR01312; EC 2.7.1.17; HMM-score: 209.5)
    Metabolism Energy metabolism Sugars gluconate kinase (TIGR01314; EC 2.7.1.12; HMM-score: 149.7)
    Metabolism Energy metabolism Sugars L-fuculokinase (TIGR02628; EC 2.7.1.51; HMM-score: 104.8)
    FGGY-family pentulose kinase (TIGR01315; EC 2.7.1.-; HMM-score: 88.9)
    Metabolism Energy metabolism Sugars ribulokinase (TIGR01234; EC 2.7.1.16; HMM-score: 63.6)
    rhamnulokinase (TIGR02627; EC 2.7.1.5; HMM-score: 53.3)
    Metabolism Energy metabolism Methanogenesis putative methanogenesis marker protein 15 (TIGR03286; HMM-score: 22.1)
    putative CoA-substrate-specific enzyme activase (TIGR00241; HMM-score: 15.9)
  • TheSEED  :
    • Glycerol kinase (EC 2.7.1.30)
    Carbohydrates Central carbohydrate metabolism Dihydroxyacetone kinases  Glycerol kinase (EC 2.7.1.30)
    and 2 more
    Carbohydrates Sugar alcohols Glycerol and Glycerol-3-phosphate Uptake and Utilization  Glycerol kinase (EC 2.7.1.30)
    Fatty Acids, Lipids, and Isoprenoids Phospholipids Glycerolipid and Glycerophospholipid Metabolism in Bacteria  Glycerol kinase (EC 2.7.1.30)
  • PFAM:
    Actin_ATPase (CL0108) FGGY_N; FGGY family of carbohydrate kinases, N-terminal domain (PF00370; HMM-score: 293.4)
    and 2 more
    FGGY_C; FGGY family of carbohydrate kinases, C-terminal domain (PF02782; HMM-score: 170.1)
    BcrAD_BadFG; BadF/BadG/BcrA/BcrD ATPase family (PF01869; HMM-score: 15.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007701
    • TAT(Tat/SPI): 0.000624
    • LIPO(Sec/SPII): 0.000944
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSQEKYIMAIDQGTTSSRAIIFNKKGEKVSSSQKEFTQIFPQAGWVEHNANEIWNSVQSVIAGAFIESGVKPNQIEAIGITNQRETTVVWDKKTGLPIYNAIVWQSRQTAPLAEQLKSQGYVEKFHEKTGLIIDAYFSATKVRWILDHVEDAQERAEKGELLFGTIDTWLVWKLTDGAAHVTDYSNAARTMLYNIKELKWDDEILEILNIPKAILPEVRSNSEIYGKTAPFHFYGGEVPISGMAGDQQAALFGQLAFEPGMVKNTYGTGSFIIMNTGEEMQLSENNLLTTIGYGINGKVYYALEGSIFIAGSAIQWLRDGLRMVENSPESEKYARDSHNNDEVYVVPAFTGLGAPYWNQNARGSVFGLTRGTSKEDFIKATLQSIAYQVRDIIDTMQVDTQTAIQVLKVDGGAAMNNFLMQFQADILGIDIARAKNLETTALGAAFLAGLSVGYWKDLDELKLLNETGELFEPSMNESRKEQLYKGWKKAVKATQVFAEVDD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CcpA* regulon
    CcpA*(TF)important in Global catabolite repression; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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