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serotype 1

NCBI: 10-NOV-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_RS03095 [old locus tag: SPG_0610 ]
  • pan locus tag?: PNEUPAN001615000
  • symbol: SPG_RS03095
  • pan gene symbol?: thyA
  • synonym:
  • product: thymidylate synthase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_RS03095 [old locus tag: SPG_0610 ]
  • symbol: SPG_RS03095
  • product: thymidylate synthase
  • replicon: chromosome
  • strand: +
  • coordinates: 606443..607282
  • length: 840
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    ATGACAAAAGCAGATACGATTTTTAAAGAGAATATTGAACGCATTCTAAAGGAAGGTGTT
    TTCTCAGAGCAGGCTCGTCCTAAGTACAAGGATGGGACTGTTGCTAATTCCAAGTATGTA
    ACTGGTGCCTTTTCCGAGTACGACTTATCTAAAGGAGAATTTCCTATCACAACCTTGCGT
    CCCATTGCAATCAAATCCGCCATCAAAGAAGTTCTCTGGATTTACCAAGACCAGTCAAAT
    AGCTTAGAGGTACTTAATGATAAGTACAATGTTCACTACTGGAATGACTGGGAAGTGGGG
    GATACAGGAACTATTGGTGAACGCTACGGTGCTGTTGTTAAGAAACACGACATCATCAAC
    AAGCTTTTCAAACAGTTGGAAGCCAACCCTTGGAACCGCCGCAATATCATTTCGCTCTGG
    GATTACCAAGCTTTCGAAGAAACAGATGGGCTACTCCCATGTGCCTTTCAGACCATGTTT
    GATGTCCGCCGTATAGATGGAGAAATCTATCTGGATGCGACCTTGACCCAGCGCTCGAAT
    GACATGCTAGTAGCCCACCACATCAACGCTATGCAGTATGTGGCTTTGCAGATGATGATT
    GCCAAGCATTTTGGCTGGAAGGTTGGAAAGTTCTTCTACTTCATCAACAACCTCCATATC
    TATGACAATCAATTTGAACAAGCTCAGGAATTACTCCGTCGTGAACCGTCAAACTGCCAA
    CCACGTTTGGTTTTGAATGTTCCTGATGGAACTAATTTCTTTGATATCAAAGCAGAAGAT
    TTTGAATTGGTGGATTATGACCCTGTTAAGCCGCAGTTGAAGTTTGACCTAGCTATTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_RS03095 [old locus tag: SPG_0610 ]
  • symbol: SPG_RS03095
  • description: thymidylate synthase
  • length: 279
  • theoretical pI: 5.22377
  • theoretical MW: 32571.8
  • GRAVY: -0.408961

⊟Function[edit | edit source]

  • reaction:
    EC 2.1.1.45?  ExPASy
    Thymidylate synthase 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides 2'-Deoxyribonucleotide metabolism thymidylate synthase (TIGR03284; EC 2.1.1.45; HMM-score: 116.3)
    and 1 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides 2'-Deoxyribonucleotide metabolism thymidylate synthase, methanogen type (TIGR03283; EC 2.1.1.-; HMM-score: 39.1)
  • TheSEED: see SPG_0610
  • PFAM:
    no clan defined Thymidylat_synt; Thymidylate synthase (PF00303; HMM-score: 210.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.009077
    • TAT(Tat/SPI): 0.000939
    • LIPO(Sec/SPII): 0.001033
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000158636 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MTKADTIFKENIERILKEGVFSEQARPKYKDGTVANSKYVTGAFSEYDLSKGEFPITTLRPIAIKSAIKEVLWIYQDQSNSLEVLNDKYNVHYWNDWEVGDTGTIGERYGAVVKKHDIINKLFKQLEANPWNRRNIISLWDYQAFEETDGLLPCAFQTMFDVRRIDGEIYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAQELLRREPSNCQPRLVLNVPDGTNFFDIKAEDFELVDYDPVKPQLKFDLAI

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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