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serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
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ATCC 49619
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ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_RS04475 [old locus tag: SPG_0888 ]
  • pan locus tag?: PNEUPAN001961000
  • symbol: SPG_RS04475
  • pan gene symbol?: pyrDb
  • synonym:
  • product: dihydroorotate dehydrogenase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_RS04475 [old locus tag: SPG_0888 ]
  • symbol: SPG_RS04475
  • product: dihydroorotate dehydrogenase
  • replicon: chromosome
  • strand: +
  • coordinates: 856121..857107
  • length: 987
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGGTCCTGTTTTCCGCACAGGAACAGTTGTATTATAAGGAGAAAATTATGACTACAAAT
    CGATTACAAGTGTCTCTACCTGGTTTGGATTTGAAAAATCCGATTATTCCAGCATCAGGC
    TGTTTTGGCTTTGGACAAGAGTATGCCAAGTACTATGATTTAAACCTTTTAGGTTCTATT
    ATGATCAAGGCGACAACCCTTGAACCACGTTTTGGGAACCCAACTCCAAGAGTAGCAGAG
    ACGCCTGCTGGTATGCTCAATGCAATTGGCTTGCAAAATCCTGGTTTAGAGGTTGTTTTG
    GCTGAAAAGCTACCTTGGCTGGAAAGAGAATATCCAAATCTTCCTATTATTGCCAATGTA
    GCTGGTTTTTCAAAACAAGAGTATGCAGCTGTTTCTCATGGGATTTCCAAGGCAACTAAT
    GTAAAAGCTATCGAGCTCAATATTTCTTGTCCCAATGTTGACCACTGTAATCATGGACTT
    TTGATTGGTCAAGATCCAGATTTGGCTTATGATGTGGTGAAAGCAGCTGTGGAAGCCTCA
    GAAGTGCCAGTTTATGTCAAATTAACCCCGAGTGTGACCGATATCGTTACTGTCGCAAAA
    GCTGCAGAAGATGCGGGAGCAAGTGGCTTGACCATGATCAATACTCTGGTTGGAATGCGC
    TTTGACCTCAAAACCAGAAAACCAATCTTGGCCAATGGAACAGGTGGAATGTCAGGTCCA
    GCAGTCTTTCCAGTAGCCCTCAAACTCATCCGCCAAGTAGCCCAAACAACAGACCTGCCT
    ATCATTGGAATGGGGGGAGTGGATTCGGCTGAAGCTGCCCTAGAAATGTATCTGGCTGGG
    GCATCTGCTATCGGAGTTGGAACAGCTAACTTTACCAATCCTTATGCCTGCCCTGACATC
    ATCGAAAATTTACCAAAAGTCATGGATAAATACGGTATTAGCAGTCTGGAAGAACTCCGT
    CAGGAAGTAAAAGAGTCTCTGAGGTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    987

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_RS04475 [old locus tag: SPG_0888 ]
  • symbol: SPG_RS04475
  • description: dihydroorotate dehydrogenase
  • length: 328
  • theoretical pI: 4.90326
  • theoretical MW: 35109.4
  • GRAVY: 0.100915

⊟Function[edit | edit source]

  • reaction:
    EC 1.3.1.14?  ExPASy
    Dihydroorotate dehydrogenase (NAD+) (S)-dihydroorotate + NAD+ = orotate + NADH
  • TIGRFAM:
    dihydroorotate dehydrogenase family protein (TIGR01037; EC 1.3.-.-; HMM-score: 361.3)
    and 12 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis dihydroorotate dehydrogenase (fumarate) (TIGR01036; EC 1.3.98.1; HMM-score: 87.8)
    Unknown function General putative TIM-barrel protein, nifR3 family (TIGR00737; HMM-score: 53.5)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA dihydrouridine synthase A (TIGR00742; EC 1.-.-.-; HMM-score: 25.2)
    Metabolism Amino acid biosynthesis Histidine family imidazoleglycerol phosphate synthase, cyclase subunit (TIGR00735; HMM-score: 18.9)
    geranylgeranylglyceryl phosphate synthase family protein (TIGR01768; EC 2.5.1.-; HMM-score: 17.6)
    glycosyl amidation-associated protein WbuZ (TIGR03572; HMM-score: 16.8)
    bifunctional HisA/TrpF protein (TIGR01919; EC 5.3.1.16,5.3.1.24; HMM-score: 16.6)
    phosphoglycerol geranylgeranyltransferase (TIGR01769; EC 2.5.1.41; HMM-score: 14.9)
    putative enoyl-[acyl-carrier-protein] reductase II (TIGR03151; EC 1.3.1.-; HMM-score: 14.8)
    5-dehydro-4-deoxyglucarate dehydratase (TIGR03249; EC 4.2.1.41; HMM-score: 14.2)
    Unknown function General putative TIM-barrel protein (TIGR00736; HMM-score: 13.6)
    Metabolism Amino acid biosynthesis Histidine family 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase (TIGR00007; EC 5.3.1.16; HMM-score: 13)
  • TheSEED: see SPG_0888
  • PFAM:
    TIM_barrel (CL0036) DHO_dh; Dihydroorotate dehydrogenase (PF01180; HMM-score: 285.4)
    and 5 more
    Dus; Dihydrouridine synthase (Dus) (PF01207; HMM-score: 44.2)
    His_biosynth; Histidine biosynthesis protein (PF00977; HMM-score: 22.4)
    NMO; Nitronate monooxygenase (PF03060; HMM-score: 14.7)
    DUF561; Protein of unknown function (DUF561) (PF04481; HMM-score: 13.8)
    G3P_antiterm; Glycerol-3-phosphate responsive antiterminator (PF04309; HMM-score: 13.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9372
    • Cytoplasmic Membrane Score: 0.0119
    • Cell wall & surface Score: 0.0011
    • Extracellular Score: 0.0497
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.022336
    • TAT(Tat/SPI): 0.001614
    • LIPO(Sec/SPII): 0.00583
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001844686 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MVLFSAQEQLYYKEKIMTTNRLQVSLPGLDLKNPIIPASGCFGFGQEYAKYYDLNLLGSIMIKATTLEPRFGNPTPRVAETPAGMLNAIGLQNPGLEVVLAEKLPWLEREYPNLPIIANVAGFSKQEYAAVSHGISKATNVKAIELNISCPNVDHCNHGLLIGQDPDLAYDVVKAAVEASEVPVYVKLTPSVTDIVTVAKAAEDAGASGLTMINTLVGMRFDLKTRKPILANGTGGMSGPAVFPVALKLIRQVAQTTDLPIIGMGGVDSAEAALEMYLAGASAIGVGTANFTNPYACPDIIENLPKVMDKYGISSLEELRQEVKESLR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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