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serotype 4
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serotype 6B
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HU-OH
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Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_RS04595 [old locus tag: SPG_0913 ]
  • pan locus tag?: PNEUPAN001988000
  • symbol: glmU
  • pan gene symbol?: glmU
  • synonym:
  • product: bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_RS04595 [old locus tag: SPG_0913 ]
  • symbol: glmU
  • product: bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU
  • replicon: chromosome
  • strand: +
  • coordinates: 878526..879905
  • length: 1380
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGTCTAATTTTGCCATTNTTTTAGCAGCGGGTAAAGGGACTCGCATGAAATCTGATTTG
    CCAAAAGTTTTGCACAAGGTTGCGGGTATTCCTATGTTGGAATATGTTNTCCGTAGTGTG
    GGAGCTATCCNNCCTNAAAAGACAGTNACAGTTGTAGGACACAAGGCAGAATTGGTTGAG
    GAGGTCTTGACTGGACAGACAGAATTTGTGACTCAATCTGAACAGTTGGGAACTGGTCAT
    GCAGTTATGATGACAGAACCTATCTTAGAAGGTTTGTCAGGACACACCTTGGTCATTGCA
    GGAGATACTCCTTTAATCACTGGTGAAAGCTTGAAAAACTTGATTGATTTCCATATCAAT
    CATAAAAATGTGGCCACTATCTTGACTGCTGAAACGGATAATCCTTTTGGCTATGGACGA
    ATTGTTCGTAATGACAATGCTGAGNTTCTTCGTATTGTTGAGCAGAAGGATGCTACAGAT
    TTTGAAAAGCAAATCAAGGAAATCAACACTGGAACATACGTCTTTGACAACGAGCGTTTG
    TTTGAGGCTTTGAAAAATATCAATACCAATAACGCTCAAGGCGAATACTATATTACAGAC
    GTCATTGGTATTTTCCGTGAAACTGGTGAAAAAGTTGGCGCTTATACTTTGAAAGATTTT
    GATGAAAGTCTTGGGGTAAATGACCGTGTGGCGCTTGCGACAGCTGAGTCAGTTATGCGT
    CGTCGCATCAATCATAAACACATGGTCAACGGTGTTAGCTTTGTCAATCCAGAAGCAACT
    TATATCGATATTGATGTTGAGATTGCTCCGGAAGTTCAAATCGAAGCCAATGTTACCTTG
    AAAGGGCAAACGAAAATTGGTGCTGAGACTGTTTTGACAAATGGTACTTATGTAGTGGAC
    AGCACTATCGGAGCAGGAGCGGTCATTACCAATTCTATGATTGAGGAAAGTAGTGTTGCA
    GACGGTGTGACAGTCGGTCCTTATGCTCACATTCGTCCAAATTCAAGTCTGGGTGCCCAA
    GTTCATATTGGTAACTTTGTTGAGGTGAAAGGATCTTCAATCGGTGAGAATACCAAGGCT
    GGTCATTTGACTTATATCGGAAACTGTGAAGTGGGAAGCAACGTTAATTTCGGTGCTGGA
    ACTATTACAGTCAACTATGACGGCAAAAACAAATACAAGACAGTCATTGGAGACAATGTC
    TTTGTTGGTTCAAATTCAACCATTATTGCACCAGTANAACTTGGTGACAATTCCCTCGTT
    GGTGCTGGTTCAACTATTACTAAAGACGTGCCAGCAGATGCTATTGCTATTGGTCGCGGT
    CGTCAGATCAATAAAGACGAATATGCAACACGTCTTCCTCATCATCCTAAGAACCAGTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_RS04595 [old locus tag: SPG_0913 ]
  • symbol: GlmU
  • description: bifunctional UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase GlmU
  • length: 459
  • theoretical pI: 5.4379
  • theoretical MW: 48663.5
  • GRAVY: -0.151435

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.7.23?  ExPASy
    UDP-N-acetylglucosamine diphosphorylase UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-alpha-D-glucosamine
    EC 2.3.1.157?  ExPASy
    Glucosamine-1-phosphate N-acetyltransferase Acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + N-acetyl-alpha-D-glucosamine 1-phosphate
  • TIGRFAM:
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR01173; EC 2.3.1.157,2.7.7.23; HMM-score: 564.9)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR01173; EC 2.3.1.157,2.7.7.23; HMM-score: 564.9)
    Metabolism Central intermediary metabolism Amino sugars UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR01173; EC 2.3.1.157,2.7.7.23; HMM-score: 564.9)
    and 22 more
    UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR03992; EC 2.3.1.157,2.7.7.23; HMM-score: 176.9)
    glucose-1-phosphate thymidylyltransferase (TIGR01208; EC 2.7.7.24; HMM-score: 86)
    sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family (TIGR03570; HMM-score: 65.1)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD (TIGR01853; EC 2.3.1.191; HMM-score: 47.9)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase (TIGR01852; EC 2.3.1.129; HMM-score: 47.3)
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides glucose-1-phosphate adenylyltransferase (TIGR02091; EC 2.7.7.27; HMM-score: 45.2)
    2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase (TIGR03532; EC 2.3.1.89; HMM-score: 41.8)
    molybdenum cofactor cytidylyltransferase (TIGR03310; EC 2.7.7.76; HMM-score: 36.4)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR03991; EC 2.3.1.157,2.7.7.23; HMM-score: 32.8)
    Metabolism Central intermediary metabolism Amino sugars UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase (TIGR03991; EC 2.3.1.157,2.7.7.23; HMM-score: 32.8)
    Metabolism Amino acid biosynthesis Serine family serine O-acetyltransferase (TIGR01172; EC 2.3.1.30; HMM-score: 31.9)
    phosphonate metabolim protein, transferase hexapeptide repeat family (TIGR03308; HMM-score: 31.7)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (TIGR00453; EC 2.7.7.60; HMM-score: 31.1)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides UTP--glucose-1-phosphate uridylyltransferase (TIGR01099; EC 2.7.7.9; HMM-score: 29.2)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides glucose-1-phosphate thymidylyltransferase (TIGR01207; EC 2.7.7.24; HMM-score: 27.7)
    colanic acid biosynthesis acetyltransferase WcaB (TIGR04016; EC 2.3.1.-; HMM-score: 26.8)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Molybdopterin molybdenum cofactor guanylyltransferase (TIGR02665; EC 2.7.7.77; HMM-score: 21.5)
    Metabolism Energy metabolism Other phenylacetic acid degradation protein PaaY (TIGR02287; HMM-score: 20.2)
    colanic acid biosynthesis acetyltransferase WcaF (TIGR04008; EC 2.3.1.-; HMM-score: 20)
    non-ribosomal peptide synthetase terminal domain of unknown function (TIGR02353; HMM-score: 15.8)
    Metabolism Amino acid biosynthesis Aspartate family 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (TIGR00965; EC 2.3.1.117; HMM-score: 13.8)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other 2-phospho-L-lactate guanylyltransferase (TIGR03552; EC 2.7.7.68; HMM-score: 12.1)
  • TheSEED: see SPG_0913
  • PFAM:
    HEXAPEP (CL0536) Hexapep; Bacterial transferase hexapeptide (six repeats) (PF00132; HMM-score: 85.1)
    and 6 more
    GT-A (CL0110) NTP_transf_3; MobA-like NTP transferase domain (PF12804; HMM-score: 60.8)
    NTP_transferase; Nucleotidyl transferase (PF00483; HMM-score: 53.9)
    HEXAPEP (CL0536) Hexapep_2; Hexapeptide repeat of succinyl-transferase (PF14602; HMM-score: 44.5)
    GT-A (CL0110) IspD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (PF01128; HMM-score: 27.1)
    HEXAPEP (CL0536) Fucokinase; L-fucokinase (PF07959; HMM-score: 13.9)
    GT-A (CL0110) CTP_transf_3; Cytidylyltransferase (PF02348; HMM-score: 13.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9953
    • Cytoplasmic Membrane Score: 0.0001
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0046
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007594
    • TAT(Tat/SPI): 0.000935
    • LIPO(Sec/SPII): 0.000738
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MSNFAIXLAAGKGTRMKSDLPKVLHKVAGIPMLEYVXRSVGAIXPXKTVTVVGHKAELVEEVLTGQTEFVTQSEQLGTGHAVMMTEPILEGLSGHTLVIAGDTPLITGESLKNLIDFHINHKNVATILTAETDNPFGYGRIVRNDNAEXLRIVEQKDATDFEKQIKEINTGTYVFDNERLFEALKNINTNNAQGEYYITDVIGIFRETGEKVGAYTLKDFDESLGVNDRVALATAESVMRRRINHKHMVNGVSFVNPEATYIDIDVEIAPEVQIEANVTLKGQTKIGAETVLTNGTYVVDSTIGAGAVITNSMIEESSVADGVTVGPYAHIRPNSSLGAQVHIGNFVEVKGSSIGENTKAGHLTYIGNCEVGSNVNFGAGTITVNYDGKNKYKTVIGDNVFVGSNSTIIAPVXLGDNSLVGAGSTITKDVPADAIAIGRGRQINKDEYATRLPHHPKNQ

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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