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serotype 4
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CGSP14
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serotype 19F
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Hu15
serotype 19A
Hu17
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serotype 14
JJA
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MDRSPN001
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NCTC7466
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NU83127
serotype 4
OXC141
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R6
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SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
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SPN994038
serotype 3
SPN994039
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SPNA45
serotype 3
ST556
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TCH8431/19A
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serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 10-NOV-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_RS05110 [old locus tag: SPG_1015 ]
  • pan locus tag?: PNEUPAN002243000
  • symbol: SPG_RS05110
  • pan gene symbol?: prs2
  • synonym:
  • product: ribose-phosphate diphosphokinase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_RS05110 [old locus tag: SPG_1015 ]
  • symbol: SPG_RS05110
  • product: ribose-phosphate diphosphokinase
  • replicon: chromosome
  • strand: -
  • coordinates: 975306..976265
  • length: 960
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGTCAGATAGAAAAAACATGAAACTTTTCGCACTCAACTCTAACCAAGAGATTGCACAA
    AAAATTGCCCAAGCTGTTGGTGTCCCACTTGGAAAACTATCATCACGTCAATTTTCAGAC
    GGAGAAATCCAAGTAAATATCGAAGAAAGTGTCCGTGGTTATGATGTTTACATCATCCAA
    TCAACAAGTTTCCCTGTCAACAACCACCTAATGGAATTGTTAATCATGGTCGATGCTTGT
    GTGCGTGCAAGTGCCCACAGTATCAACGTTGTCCTTCCATATTTTGGCTATGCACGTCAA
    GACCGCATTGCTTGTCCTCGTGAGCCACTTACAGCAAAACTAGTTGCCAATATGCTGGTT
    AAGGCTGGAGTTGATCGTATCCTGACTCTTGATTTGCATGCCGTTCAGGTTCAAGGTTTC
    TTTGATATTCCAGTGGATAATCTTTTCACTGTTCCCCTATTCGCAAAACATTACTGCGAT
    AAAGGATTGCTTGGTTCANATGTTGTTGTCGTTAGCCCTAAAAATTCAGGTGTCAAACGT
    GCGCGTAGCCTGGCTGAATATCTTGATGCTCCNATCGCCATTATCGACTACCCTCAAGAC
    GATGCAACTCGTAACGAAGGTTATATTATTGGTGATGTTGAAGGTAAGAAAGCTATCNTG
    ATTGATGATATTTTAAATACAGGACGTACCTTCTCTGAAGCTTCTAAAATCGTTGAACGT
    GAAGGAGCTACAGAAATTTATGCTGTTTCTAGCCACGGTCTCTTCGTCGAGGGAGCTGCT
    GAGCTTCTTGACAATACTAATATTAAAGAAATTCTTGTGACTGATTCAGTAGCAACAAAA
    GAAAAAACTCCTAAAAATGTATGCTACATCACTGCTAGTGAGTTAATTGGTGATGCTATC
    GTCCGTATTCACGAAAGAAAACCAGTCAGCCCACTCTTTGCCTACAATAAAAAGAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_RS05110 [old locus tag: SPG_1015 ]
  • symbol: SPG_RS05110
  • description: ribose-phosphate diphosphokinase
  • length: 319
  • theoretical pI: 6.51954
  • theoretical MW: 34896.9
  • GRAVY: -0.0236593

⊟Function[edit | edit source]

  • reaction:
    EC 2.7.6.1?  ExPASy
    Ribose-phosphate diphosphokinase ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate
  • TIGRFAM:
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis ribose-phosphate diphosphokinase (TIGR01251; EC 2.7.6.1; HMM-score: 336.8)
    and 4 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis orotate phosphoribosyltransferase (TIGR01367; EC 2.4.2.10; HMM-score: 20.4)
    Cellular processes Cellular processes DNA transformation comF family protein (TIGR00201; HMM-score: 19.9)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis orotate phosphoribosyltransferase (TIGR00336; EC 2.4.2.10; HMM-score: 16.7)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Salvage of nucleosides and nucleotides hypoxanthine phosphoribosyltransferase (TIGR01203; EC 2.4.2.8; HMM-score: 14.1)
  • TheSEED: see SPG_1015
  • PFAM:
    PRTase-like (CL0533) Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase (PF13793; HMM-score: 164.5)
    and 3 more
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain (PF14572; HMM-score: 81.1)
    Pribosyltran; Phosphoribosyl transferase domain (PF00156; HMM-score: 41.1)
    HAD (CL0137) Hydrolase_3; haloacid dehalogenase-like hydrolase (PF08282; HMM-score: 14.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.67
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 0.15
    • Extracellular Score: 0.17
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.01365
    • TAT(Tat/SPI): 0.005901
    • LIPO(Sec/SPII): 0.001647
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_001283815 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSDRKNMKLFALNSNQEIAQKIAQAVGVPLGKLSSRQFSDGEIQVNIEESVRGYDVYIIQSTSFPVNNHLMELLIMVDACVRASAHSINVVLPYFGYARQDRIACPREPLTAKLVANMLVKAGVDRILTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCDKGLLGSXVVVVSPKNSGVKRARSLAEYLDAPIAIIDYPQDDATRNEGYIIGDVEGKKAIXIDDILNTGRTFSEASKIVEREGATEIYAVSSHGLFVEGAAELLDNTNIKEILVTDSVATKEKTPKNVCYITASELIGDAIVRIHERKPVSPLFAYNKKK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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