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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 10-NOV-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae G54
  • locus tag: SPG_RS09725 [old locus tag: SPG_1943 ]
  • pan locus tag?: PNEUPAN003627000
  • symbol: tkt
  • pan gene symbol?: ulaH
  • synonym:
  • product: transketolase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPG_RS09725 [old locus tag: SPG_1943 ]
  • symbol: tkt
  • product: transketolase
  • replicon: chromosome
  • strand: -
  • coordinates: 1844975..1846951
  • length: 1977
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_011072 (1844975..1846951) NCBI
  • BioCyc: SPG_RS09725 BioCyc
  • MicrobesOnline: see SPG_1943
  • PneumoBrowse for strain D39V: SPV_1839 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    ATGTCAAATCTATCTGTTAATGCAATTCGTTTTCTAGGTATTGACGCCATTAATAAAGCC
    AACTCAGGTCATCCAGGTGTGGTTATGGGAGCGGCTCCGATGGCTTACAGCCTCTTTACA
    AAACAACTTCATATCAATCCAGCTCAACCAAATTGGATTAACCGCGACCGCTTTATTCTT
    TCAGCAGGTCATGGTTCAATGCTCCTTTATGCTCTTCTTCACCTTTCTGGTTTTGAAGAT
    GTCAGCATGAATGAGATTAAGAGCTTCCGTCAATGGGGTTCAAAAACACCAGGTCACCCA
    GAATTTGGTCATACGGCAGGGATTGATGCTACGACAGGTCCTCTAGGGCAAGGGATTTCA
    ACTGCTACTGGTTTTGCCCAAGCAGAACGTTTCTTGGCAGCCAAATATAACCGTGAAGGC
    TACAATATCTTTGACCACTATACTTACGTTATCTGTGGAGACGGAGACTTGATGGAAGGT
    GTCTCAAGCGAGGCAGCTTCATACGCAGGTTTGCAAAAACTTGATAAGTTGGTTGTTCTT
    TATGATTCAAATGATATCAACTTGGATGGTGAGACAAAGGATTCCTTTACAGAAAGTGTT
    CGTGACCGTTACAATGCCTACGGTTGGCATACTGCCTTGGTTGAAAATGGAACAGACTTG
    GAAGCCATCCATGCTGCTATCGAAACAGCAAAAGCTTCAGGCAAGCCATCTTTGATTGAA
    GTGAAGACGGTTATTGGATACGGTTCTCCAAACAAACAAGGAACTAATGCTGTACACGGC
    GCCCCTCTTGGAGCAGATGAAACTGCATCAACTCGCCAAGCCCTCGGTTGGGACTACGAA
    CCATTTGAAATTCCAGAACAAGTATATGCTGATTTCAAAGAACATGTTGCAGACCGTGGC
    GCATCAGCTTATCAAGCTTGGACTAAATTAGTTGCAGATTATAAAGAAGTTCATCCAGAA
    CTGGCTGCAGAAGTAGAAGCCATCATCGACGGACGTGATCCAGTCGAAGTGACTCCAGCA
    GACTTCCCAGCTTTAGAAAATGGTTTTTCTCAAGCAACTCGTAATTCAAGTCAAGATGCC
    TTGAATGTTGTGGCAGCTAAATTACCAACCTTCCTAGGTGGATCAGCTGACCTTGCTCAC
    TCAAACATGACTTATATCAAGACGGATGGACTTCAAGACGATGCCAATCGCTTGAATCGT
    AACATTCAGTTTGGTGTTCGTGAATTTGCAATGGGAACAATCTTGAACGGGATGGCCCTT
    CATGGTGGACTTCGTGTATACGGTGGAACTTTCTTCGTCTTCTCTGACTATGTGAAGGCA
    GCTGTCCGCTTGTCAGCCTTACAAGGACTTCCTGTGACTTATGTCTTTACCCATGATTCA
    ATCGCAGTTGGGGAAGATGGTCCGACTCACGAACCAGTTGAGCATTTAGCAGGTCTTCGT
    GCTATGCCAAATCTAAATGTTTTCCGTCCAGCAGATGCGCGTGAAACGCAAGCAGCTTGG
    TACCTTGCAGTGACAAGTGAGAAAACACCAACTGCCCTTGTCTTGACACGTCAAAACTTG
    ACTGTTGAAGATGGAACAGACTTCGACAAGGTTGCTAAAGGTGCTTATGTTGTATATGAA
    AATGCAGCCGACTTTGATACCATCTTGATTGCGACAGGTTCAGAGGTTAATCTTGCTGTC
    TCAGCTGCTAAAGAATTGGCTAGTCAAGGCGAAAAAATCCGCGTAGTCAGCATGCCATCT
    ACAGATGTCTTTGATAAACAAGATGCAGCTTACAAGGAAGAAATTCTTCCAAATGCAGTC
    CGCCGTCGTGTTGCAGTCGAAATGGGTGCAAGTCAAAACTGGTACAAATATGTTGGTCTC
    GATGGTGCCGTTCNAGGTATTGATACCTTCGGAGCCTCTGCCCCAGCACCAAAAGTATTG
    GCAGAATATGGCTTTACTGTCGAAAATCTTGTAAAAGTTGTTCGAAATTTGAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1977

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPG_RS09725 [old locus tag: SPG_1943 ]
  • symbol: Tkt
  • description: transketolase
  • length: 658
  • theoretical pI: 4.89141
  • theoretical MW: 71011.1
  • GRAVY: -0.181887

⊟Function[edit | edit source]

  • reaction:
    EC 2.2.1.1?  ExPASy
    Transketolase Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate
  • TIGRFAM:
    Metabolism Energy metabolism Pentose phosphate pathway transketolase (TIGR00232; EC 2.2.1.1; HMM-score: 926.3)
    and 7 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 57.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Thiamine 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 57.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Pyridoxine 1-deoxy-D-xylulose-5-phosphate synthase (TIGR00204; EC 2.2.1.7; HMM-score: 57.9)
    pyruvate dehydrogenase (acetyl-transferring), homodimeric type (TIGR00759; EC 1.2.4.1; HMM-score: 26.5)
    Metabolism Energy metabolism Pyruvate dehydrogenase pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit (TIGR03181; EC 1.2.4.1; HMM-score: 22.8)
    Metabolism Energy metabolism Pyruvate dehydrogenase pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit (TIGR03182; EC 1.2.4.1; HMM-score: 20.5)
    alpha-ketoglutarate dehydrogenase (TIGR03186; HMM-score: 20.5)
  • TheSEED: see SPG_1943
  • PFAM:
    THDP-binding (CL0254) Transketolase_N; Transketolase, thiamine diphosphate binding domain (PF00456; HMM-score: 521.6)
    and 5 more
    Transket_pyr; Transketolase, pyrimidine binding domain (PF02779; HMM-score: 153.4)
    TKC_like (CL0591) Transketolase_C; Transketolase, C-terminal domain (PF02780; HMM-score: 58.4)
    THDP-binding (CL0254) TPP_enzyme_C; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain (PF02775; HMM-score: 20.1)
    E1_dh; Dehydrogenase E1 component (PF00676; HMM-score: 16.4)
    DXP_synthase_N; 1-deoxy-D-xylulose-5-phosphate synthase (PF13292; HMM-score: 13.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.022159
    • TAT(Tat/SPI): 0.003847
    • LIPO(Sec/SPII): 0.002771
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000067876 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSNLSVNAIRFLGIDAINKANSGHPGVVMGAAPMAYSLFTKQLHINPAQPNWINRDRFILSAGHGSMLLYALLHLSGFEDVSMNEIKSFRQWGSKTPGHPEFGHTAGIDATTGPLGQGISTATGFAQAERFLAAKYNREGYNIFDHYTYVICGDGDLMEGVSSEAASYAGLQKLDKLVVLYDSNDINLDGETKDSFTESVRDRYNAYGWHTALVENGTDLEAIHAAIETAKASGKPSLIEVKTVIGYGSPNKQGTNAVHGAPLGADETASTRQALGWDYEPFEIPEQVYADFKEHVADRGASAYQAWTKLVADYKEVHPELAAEVEAIIDGRDPVEVTPADFPALENGFSQATRNSSQDALNVVAAKLPTFLGGSADLAHSNMTYIKTDGLQDDANRLNRNIQFGVREFAMGTILNGMALHGGLRVYGGTFFVFSDYVKAAVRLSALQGLPVTYVFTHDSIAVGEDGPTHEPVEHLAGLRAMPNLNVFRPADARETQAAWYLAVTSEKTPTALVLTRQNLTVEDGTDFDKVAKGAYVVYENAADFDTILIATGSEVNLAVSAAKELASQGEKIRVVSMPSTDVFDKQDAAYKEEILPNAVRRRVAVEMGASQNWYKYVGLDGAVXGIDTFGASAPAPKVLAEYGFTVENLVKVVRNLK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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