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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_0494 [new locus tag: SPH_RS02405 ]
  • pan locus tag?: PNEUPAN001252000
  • symbol: SPH_0494
  • pan gene symbol?: vraR
  • synonym:
  • product: response regulator

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_0494 [new locus tag: SPH_RS02405 ]
  • symbol: SPH_0494
  • product: response regulator
  • replicon: chromosome
  • strand: +
  • coordinates: 449362..449994
  • length: 633
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGTTTGGGTTTGAAAAGCTACTTT
    GACCTCCAAGACGATGTAGAAGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGAC
    TTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATATTGTCATGCCTGAGATGAAT
    GGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
    ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTAT
    ATGCTCAAGACTTCTAGTGCAGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGC
    GAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAATACCACCGCAATCATATGGAA
    CTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
    GAAAATCAGCGCATCGCAGATGACCTCTTCATCTCTCTCAAGACGGTCAAGACCCACGTG
    TCCAACATTCTTGCCAAACTTGAAGTTAGCGATCGTACCCAGGCGGCTGTCTATGCCTTT
    CAGCACCATTTGGTCGGGCATGAGGAGTTTTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    633

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_0494 [new locus tag: SPH_RS02405 ]
  • symbol: SPH_0494
  • description: response regulator
  • length: 210
  • theoretical pI: 4.64916
  • theoretical MW: 23561.9
  • GRAVY: -0.077619

⊟Function[edit | edit source]

  • TIGRFAM:
    Cellular processes Cellular processes Sporulation and germination sporulation transcription factor Spo0A (TIGR02875; HMM-score: 69.1)
    and 13 more
    transcriptional regulator EpsA (TIGR03020; HMM-score: 46.6)
    Metabolism Central intermediary metabolism Nitrogen metabolism nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 43.4)
    Signal transduction Regulatory functions DNA interactions nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 43.4)
    Signal transduction Signal transduction Two-component systems nitrogen regulation protein NR(I) (TIGR01818; HMM-score: 43.4)
    Signal transduction Regulatory functions DNA interactions phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 37.8)
    Signal transduction Signal transduction Two-component systems phosphate regulon transcriptional regulatory protein PhoB (TIGR02154; HMM-score: 37.8)
    Signal transduction Regulatory functions DNA interactions heavy metal response regulator (TIGR01387; HMM-score: 36.8)
    LuxR family transcriptional regulatory, chaperone HchA-associated (TIGR03541; HMM-score: 35.3)
    Signal transduction Regulatory functions DNA interactions PEP-CTERM-box response regulator transcription factor (TIGR02915; HMM-score: 25.6)
    RNA polymerase sigma-70 factor, Bacteroides expansion family 1 (TIGR02985; HMM-score: 25.6)
    RNA polymerase sigma factor, sigma-70 family (TIGR02937; HMM-score: 25)
    Cellular processes Cellular processes Sporulation and germination RNA polymerase sigma-H factor (TIGR02859; HMM-score: 12.8)
    Genetic information processing Transcription Transcription factors RNA polymerase sigma-H factor (TIGR02859; HMM-score: 12.8)
  • TheSEED  :
    • Two component transcriptional regulator VraR
  • PFAM:
    CheY (CL0304) Response_reg; Response regulator receiver domain (PF00072; HMM-score: 90.6)
    HTH (CL0123) GerE; Bacterial regulatory proteins, luxR family (PF00196; HMM-score: 77.5)
    and 4 more
    Sigma70_r4_2; Sigma-70, region 4 (PF08281; HMM-score: 29.2)
    Sigma70_r4; Sigma-70, region 4 (PF04545; HMM-score: 21.3)
    no clan defined DUF3071; Protein of unknown function (DUF3071) (PF11268; HMM-score: 12.8)
    HTH (CL0123) HTH_23; Homeodomain-like domain (PF13384; HMM-score: 12.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002273
    • TAT(Tat/SPI): 0.000108
    • LIPO(Sec/SPII): 0.000274
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIVTSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGYENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGHEEF

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Vegard Eldholm, Beatrice Gutt, Ola Johnsborg, Reinhold Brückner, Patrick Maurer, Regine Hakenbeck, Thorsten Mascher, Leiv Sigve Håvarstein
The pneumococcal cell envelope stress-sensing system LiaFSR is activated by murein hydrolases and lipid II-interacting antibiotics.
J Bacteriol: 2010, 192(7);1761-73
[PubMed:20118250] [WorldCat.org] [DOI] (I p)

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