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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_0535 [new locus tag: SPH_RS02605 ]
  • pan locus tag?: PNEUPAN001295000
  • symbol: accD
  • pan gene symbol?: accD
  • synonym:
  • product: acetyl-CoA carboxylase, carboxyl transferase, beta subunit

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_0535 [new locus tag: SPH_RS02605 ]
  • symbol: accD
  • product: acetyl-CoA carboxylase, carboxyl transferase, beta subunit
  • replicon: chromosome
  • strand: +
  • coordinates: 485605..486471
  • length: 867
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGGCTCTATTTAGTAAAAAAGATAAGTATATTCGAATCAATCCCAATCGTTCGGTTAGG
    GAAAAACCTCAAGCTAAGCCAGAGGTTCCAGATGAATTATTTTCCCAGTGTCCAGGCTGT
    AAGCATACCATCTATCAGAAGGATCTGGGAAGTGAACGTATCTGTCCGCACTGTAGCTAT
    ACCTTTCGTATTTCTGCCCAAGAACGCTTGGCTTTGACGATTGATATGGGAACCTTCAAA
    GAATTGTTTACAGGGATTGAAAGCAAGGATCCCTTGCATTTCCCTGGTTACCAAAAGAAA
    CTGGCATCTATGCGTGAAAAAACAGGTCTGCATGAAGCCGTTGTGACAGGAACTGCTCTT
    ATTAAAGGTCAGACTGTGGCTCTTGGGATTATGGATTCTAACTTTATCATGGCTTCTATG
    GGTACGGTTGTAGGTGAAAAAATCACTCGTTTGTTTGAGTATGCGACTGTCGAAAAATTG
    CCAGTTGTCCTATTCACAGCCTCTGGTGGAGCCCGTATGCAGGAAGGAATCATGAGTCTC
    ATGCAGATGGCTAAGATCTCTGCGGCGGTTAAACGCCATTCAAATGCTGGTCTCTTTTAC
    CTGACCATTTTGACAGATCCAACGACTGGTGGTGTGACAGCATCTTTCGCTATGGAAGGC
    GATATCATTCTGGCTGAACCACAGAGCTTGGTTGGTTTTGCTGGGCGTCGTGTGATTGAA
    AATACGGTTCGTGAAAGCTTGCCTGAGGATTTCCAAAAGGCAGAATTCCTATTAGAACAT
    GGCTTTGTGGATGCTATTGTCAAAAGAAGAGACTTACCAGATACGATTGCTAGCCTAGTC
    AGATTGCATGGAGGGAGTCCTAGATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    867

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_0535 [new locus tag: SPH_RS02605 ]
  • symbol: AccD
  • description: acetyl-CoA carboxylase, carboxyl transferase, beta subunit
  • length: 288
  • theoretical pI: 8.87461
  • theoretical MW: 31785.7
  • GRAVY: -0.110764

⊟Function[edit | edit source]

  • reaction:
    EC 6.4.1.2?  ExPASy
    Acetyl-CoA carboxylase ATP + acetyl-CoA + HCO3(-) = ADP + phosphate + malonyl-CoA
  • TIGRFAM:
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis acetyl-CoA carboxylase, carboxyl transferase, beta subunit (TIGR00515; EC 6.4.1.2; HMM-score: 347.8)
    and 7 more
    Metabolism Transport and binding proteins Cations and iron carrying compounds methylmalonyl-CoA decarboxylase alpha subunit (TIGR01117; EC 4.1.1.41; HMM-score: 54)
    Metabolism Energy metabolism Fermentation methylmalonyl-CoA decarboxylase alpha subunit (TIGR01117; EC 4.1.1.41; HMM-score: 54)
    Metabolism Energy metabolism ATP-proton motive force interconversion methylmalonyl-CoA decarboxylase alpha subunit (TIGR01117; EC 4.1.1.41; HMM-score: 54)
    biotin-independent malonate decarboxylase, beta subunit (TIGR03133; EC 4.1.1.88; HMM-score: 53.4)
    Unknown function General integral membrane protein, PqiA family (TIGR00155; HMM-score: 17.4)
    Metabolism Energy metabolism Glycolysis/gluconeogenesis phosphoglycerate mutase (2,3-diphosphoglycerate-independent), archaeal form (TIGR00306; EC 5.4.2.12; HMM-score: 11.5)
    MJ0042 family finger-like domain (TIGR02098; HMM-score: 11.1)
  • TheSEED  :
    • Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2)
    Fatty Acids, Lipids, and Isoprenoids Fatty acids Fatty Acid Biosynthesis FASII  Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2)
    and 1 more
    Virulence, Disease and Defense Bacteriocins, ribosomally synthesized antibacterial peptides Colicin V and Bacteriocin Production Cluster  Acetyl-coenzyme A carboxyl transferase beta chain (EC 6.4.1.2)
  • PFAM:
    ClpP_crotonase (CL0127) Carboxyl_trans; Carboxyl transferase domain (PF01039; HMM-score: 60.1)
    and 6 more
    TRAF (CL0389) zf-ACC; Acetyl-coA carboxylase zinc finger domain (PF17848; HMM-score: 23.9)
    RING (CL0229) IBR; IBR domain, a half RING-finger domain (PF01485; HMM-score: 14.2)
    no clan defined Cys_rich_CPCC; Cysteine-rich CPCC (PF14206; HMM-score: 13.5)
    Zn_Tnp_IS91; Transposase zinc-binding domain (PF14319; HMM-score: 12.3)
    Zn_Beta_Ribbon (CL0167) zinc_ribbon_4; zinc-ribbon domain (PF13717; HMM-score: 11.8)
    UPF0547; Uncharacterised protein family UPF0547 (PF10571; HMM-score: 9.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.025061
    • TAT(Tat/SPI): 0.001421
    • LIPO(Sec/SPII): 0.003462
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MALFSKKDKYIRINPNRSVREKPQAKPEVPDELFSQCPGCKHTIYQKDLGSERICPHCSYTFRISAQERLALTIDMGTFKELFTGIESKDPLHFPGYQKKLASMREKTGLHEAVVTGTALIKGQTVALGIMDSNFIMASMGTVVGEKITRLFEYATVEKLPVVLFTASGGARMQEGIMSLMQMAKISAAVKRHSNAGLFYLTILTDPTTGGVTASFAMEGDIILAEPQSLVGFAGRRVIENTVRESLPEDFQKAEFLLEHGFVDAIVKRRDLPDTIASLVRLHGGSPR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: FabT* (repression) regulon
    FabT*(TF)important in Fatty acid biosynthesis; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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