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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_1190 [new locus tag: SPH_RS05775 ]
  • pan locus tag?: PNEUPAN002247000
  • symbol: SPH_1190
  • pan gene symbol?: rluD3
  • synonym:
  • product: ribosomal large subunit pseudouridine synthase, RluD subfamily

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_1190 [new locus tag: SPH_RS05775 ]
  • symbol: SPH_1190
  • product: ribosomal large subunit pseudouridine synthase, RluD subfamily
  • replicon: chromosome
  • strand: +
  • coordinates: 1091902..1092798
  • length: 897
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGAGGTTTGAATTTATCGCAGATGAACATGTCAAGGTTAAGACCTTCTTAAAAAAGCAC
    GAGGTTTCTAAGGGATTGCTGGCCAAGATTAAGTTTCGAGGTGGAGCTATTCTGGTCAAT
    AATCAACCGCAAAATGCAACGTATCTATTGGACGTTGGAGACTACGTTACCATTGACATT
    CCCGCTGAGAAAGGCTTTGAAACCTTGGAGGCTATTGAGCTTCCATTAGATATTCTCTAT
    GAGGATGACCACTTTCTAGTCTTGAATAAACCCTATGGAGTGGCTTCTATTCCTAGTGTT
    AATCACTCTAATACCATTGCCAATTTTATCAAGGGTTACTATGTCAAGCAAAATTATGAA
    AATCAGCAGGTTCACATTGTTACCAGACTAGATAGGGACACTTCTGGCTTGATGCTCTTT
    GCCAAGCACGGTTATGCCCATGCACGATTAGACAAGCAGTTGCAGAAGAAATCTATCGAG
    AAACGCTACTTTGCTTTGGTTAAGGGAGATGGACATTTGGAACCAGAAGGGGAAATTATT
    GCTCCGATTGCGCGTGATGAAGATTCCATTATTACCAGACGAGTGGCTAAAGGCGGAAAG
    TATGCCCATACTTCATACAAGATTGTAGCTTCTTATGGAAATATTCACTTGGTCTATATT
    CACCTGCACACTGGTCGAACCCATCAAATCCGAGTCCATTTTTCTCATATCGGTTTTCCT
    TTGCTGGGAGATGATTTGTATGGTGGTAGTCTGGAAGATGGTATTCAACGTCAGGCTCTG
    CATTGCCATTACCTATCCTTTTATCATCCATTTTTAGAGCAAGACTTGCAGTTAGAAAGT
    CCCTTGCCGGATGATTTCAGTAACCTTATTACCCAGTTATCAACTAATACTCTATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    897

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_1190 [new locus tag: SPH_RS05775 ]
  • symbol: SPH_1190
  • description: ribosomal large subunit pseudouridine synthase, RluD subfamily
  • length: 298
  • theoretical pI: 7.03796
  • theoretical MW: 33893.3
  • GRAVY: -0.285906

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein synthesis tRNA and rRNA base modification pseudouridine synthase, RluA family (TIGR00005; EC 5.4.99.-; HMM-score: 239.8)
    and 3 more
    Genetic information processing Protein synthesis tRNA and rRNA base modification pseudouridine synthase Rlu family protein, TIGR01621 (TIGR01621; EC 5.4.99.-; HMM-score: 90)
    Genetic information processing Protein synthesis tRNA and rRNA base modification pseudouridine synthase (TIGR00093; EC 5.4.99.-; HMM-score: 39.4)
    Metabolism Energy metabolism TCA cycle isocitrate dehydrogenase, NADP-dependent (TIGR00127; EC 1.1.1.42; HMM-score: 10)
  • TheSEED  :
    • tRNA pseudouridine(32) synthase YjbO
    Protein Metabolism Protein biosynthesis Ribosome biogenesis bacterial  Similar to ribosomal large subunit pseudouridine synthase D, Bacillus subtilis YjbO type
  • PFAM:
    PseudoU_synth (CL0649) PseudoU_synth_2; RNA pseudouridylate synthase (PF00849; HMM-score: 113.7)
    and 1 more
    S4 (CL0492) S4_2; S4 domain (PF13275; HMM-score: 14.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002851
    • TAT(Tat/SPI): 0.000459
    • LIPO(Sec/SPII): 0.000475
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MRFEFIADEHVKVKTFLKKHEVSKGLLAKIKFRGGAILVNNQPQNATYLLDVGDYVTIDIPAEKGFETLEAIELPLDILYEDDHFLVLNKPYGVASIPSVNHSNTIANFIKGYYVKQNYENQQVHIVTRLDRDTSGLMLFAKHGYAHARLDKQLQKKSIEKRYFALVKGDGHLEPEGEIIAPIARDEDSIITRRVAKGGKYAHTSYKIVASYGNIHLVYIHLHTGRTHQIRVHFSHIGFPLLGDDLYGGSLEDGIQRQALHCHYLSFYHPFLEQDLQLESPLPDDFSNLITQLSTNTL

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CcpA regulon
    CcpA(TF)important in Global catabolite repression; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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