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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_2228 [new locus tag: SPH_RS10915 ]
  • pan locus tag?: PNEUPAN000124000
  • symbol: SPH_2228
  • pan gene symbol?: ftsK_2
  • synonym:
  • product: putative otitis media-associated H10

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_2228 [new locus tag: SPH_RS10915 ]
  • symbol: SPH_2228
  • product: putative otitis media-associated H10
  • replicon: chromosome
  • strand: +
  • coordinates: 2046445..2047764
  • length: 1320
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGTTTAAATTAAGACAAAGTGCTGATTTAACCAAAACTTATATTATTACTAGCAGTAAA
    TTGAAGACAGTACATTTTTCAATAATAGCACTCACTATCTGCATTATATGTGCTATTATT
    GCCAATATAAGGGCTCCAACTTTTGTTCAAATTCTCTTCATATTTTTAGGTGGATTTATT
    ATCTATAAAATTCATCTGAAAATAAAAATTTTTCGATATAACTTAGAGTATTACCTTATT
    ATACGTGAGAGCTTACTTTATGTACTACACACAAACAGACTTTATACCACATCTAAAGAT
    AGTTCAGGCTATGAAAAAATCATCAGAAGTGCAGCATTAGAATACGAGATAGATAGACAA
    AAAGGTCATGTTCTTATCAAAGCTCTTATAACGGGCGATGAATTTACAAAAAAACTTCAA
    GCTCTTGATGATTTGCTTTGTGGCGCGCTTGGACTAGAGCTTGACGAGAAGATTCTTCGG
    GCTAGTGTTGCAGAGTATCATTTCTATTACATAAAACCAAAAAGGTTAGTTCTACAATCT
    CACAACCAAAGACGAGAGATAGATAGCCTTGATATAGATTTAGGATATGGTGTAAATTAT
    AACCCAATAAAATGCCCACATATTTTAGTATCAGGAGGAACAGGGAGCGGAAAGTCTGTC
    TTCATATCTTTCCTGATTTTAGAACTTCTCAAACGGCAATCAACAGTCTATATTGCTGAC
    CCTAAAAATAGTGATTTAGGCAGTTTGTCACACTATATTGGAGATAAATATGTATCTACA
    AACCCTAACAATATCGCACGAGTTGTTCGACTAGTCGTCGAGGCAATGACGGCACGCTAT
    CAAATTATGCGTGATAACTTTCAATACGCTTCAAATTTTTCAGAGCACGGCTTTAAGCCG
    ATATGGTTGATATTAGATGAAATGGGAGCATTTCAAGCTTCAGGAACGGATAAAAAATCA
    AAAGAAGTTATAGTTGAAGTTATGGACGGTATCAAGCAAATCATTCTACTTGGGCGACAA
    GCTGGGGTATTTATCCTAATTTCAGCTCAACAAATGAGAGCCGAAACCTTAAATACCGAC
    CTTAGAGATAACCTAGGCTTGAGAATTGCTCTTGGTGCAAATTCTAGCGAGGGTTATCGA
    ATGGTCTTTGGTTCTGCTACCCCTGATAAATTAAAGCCAATTGAGGTAAAAGGGGCTGGC
    TATCTTTACATGCAAGGTTCAGGAAAAGAAACGGCTCAATATTGGGAAAGTCCTTATCTT
    GATACAACACAATTCGATTTTATAAAAGAACTACAATTATATATAACAAAGTTAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_2228 [new locus tag: SPH_RS10915 ]
  • symbol: SPH_2228
  • description: putative otitis media-associated H10
  • length: 439
  • theoretical pI: 9.41293
  • theoretical MW: 49829.6
  • GRAVY: 0.0102506

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VII secretion protein EssC (TIGR03928; HMM-score: 41)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VII secretion protein EccCa (TIGR03924; HMM-score: 40.4)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VII secretion protein EccCb (TIGR03925; HMM-score: 37.1)
    and 6 more
    type IV secretion/conjugal transfer ATPase, VirB4 family (TIGR00929; HMM-score: 21.5)
    Genetic information processing Mobile and extrachromosomal element functions Other conjugative coupling factor TraD, SXT/TOL subfamily (TIGR03743; HMM-score: 20.7)
    type IV conjugative transfer system coupling protein TraD (TIGR02759; HMM-score: 14.7)
    type-IV secretion system protein TraC (TIGR02746; HMM-score: 13.6)
    helicase/secretion neighborhood ATPase (TIGR03819; HMM-score: 12)
    P-type DNA transfer ATPase VirB11 (TIGR02788; HMM-score: 11.1)
  • TheSEED  :
    • FtsK/SpoIIIE family
  • PFAM:
    P-loop_NTPase (CL0023) FtsK_SpoIIIE; FtsK/SpoIIIE family (PF01580; HMM-score: 52.4)
    and 15 more
    DUF87; Helicase HerA, central domain (PF01935; HMM-score: 24.2)
    T2SSE; Type II/IV secretion system protein (PF00437; HMM-score: 20.7)
    AAA_22; AAA domain (PF13401; HMM-score: 20.1)
    AAA_10; AAA-like domain (PF12846; HMM-score: 18.1)
    TrwB_AAD_bind; Type IV secretion-system coupling protein DNA-binding domain (PF10412; HMM-score: 17.9)
    T4SS-DNA_transf; Type IV secretory system Conjugative DNA transfer (PF02534; HMM-score: 17.4)
    Pox_A32; Poxvirus A32 protein (PF04665; HMM-score: 15.9)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 14.5)
    CLP1_P; mRNA cleavage and polyadenylation factor CLP1 P-loop (PF16575; HMM-score: 14)
    P-loop_TraG; TraG P-loop domain (PF19044; HMM-score: 13.4)
    RNA_helicase; RNA helicase (PF00910; HMM-score: 13)
    DUF2075; Schlafen group 3, DNA/RNA helicase domain (PF09848; HMM-score: 12.7)
    DEAD; DEAD/DEAH box helicase (PF00270; HMM-score: 12.2)
    CobU; Cobinamide kinase / cobinamide phosphate guanyltransferase (PF02283; HMM-score: 11.7)
    Zeta_toxin; Zeta toxin (PF06414; HMM-score: 11.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 1.05
    • Cytoplasmic Membrane Score: 8.78
    • Cellwall Score: 0.08
    • Extracellular Score: 0.09
    • Internal Helices: 2
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0038
    • Cytoplasmic Membrane Score: 0.8905
    • Cell wall & surface Score: 0.001
    • Extracellular Score: 0.1047
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.003449
    • TAT(Tat/SPI): 0.00018
    • LIPO(Sec/SPII): 0.023357
  • predicted transmembrane helices (TMHMM): 2

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MFKLRQSADLTKTYIITSSKLKTVHFSIIALTICIICAIIANIRAPTFVQILFIFLGGFIIYKIHLKIKIFRYNLEYYLIIRESLLYVLHTNRLYTTSKDSSGYEKIIRSAALEYEIDRQKGHVLIKALITGDEFTKKLQALDDLLCGALGLELDEKILRASVAEYHFYYIKPKRLVLQSHNQRREIDSLDIDLGYGVNYNPIKCPHILVSGGTGSGKSVFISFLILELLKRQSTVYIADPKNSDLGSLSHYIGDKYVSTNPNNIARVVRLVVEAMTARYQIMRDNFQYASNFSEHGFKPIWLILDEMGAFQASGTDKKSKEVIVEVMDGIKQIILLGRQAGVFILISAQQMRAETLNTDLRDNLGLRIALGANSSEGYRMVFGSATPDKLKPIEVKGAGYLYMQGSGKETAQYWESPYLDTTQFDFIKELQLYITKLK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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