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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_2351 [new locus tag: SPH_RS11510 ]
  • pan locus tag?: PNEUPAN003820000
  • symbol: SPH_2351
  • pan gene symbol?: adh2
  • synonym:
  • product: NAD-dependent methanol dehydrogenase (medh)

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_2351 [new locus tag: SPH_RS11510 ]
  • symbol: SPH_2351
  • product: NAD-dependent methanol dehydrogenase (medh)
  • replicon: chromosome
  • strand: -
  • coordinates: 2156073..2157224
  • length: 1152
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGGCTACATTTTATGTTCCGGCAGTCAACCTTATTGGAAAAGGTGTTGTAAATGAAGTG
    GGTCCTTATATCAAGGAACTTGGCTATAAAAAGGCACTTTTGGTTACAGATAAGTACATC
    GAAGGCAGTGATATTTTACCTAAGACTTTAAAACCACTGGATACAGAAGGAATCGAATAT
    GTCATCTTTAGCGATGTAGAGCCAAACCCTACTTGTAAAAATGTCACAGATGGGGTAGCT
    GCTTTGCAAGAACATGGCTGTGACTTTATCATCAGTCTTGGCGGGGGTTCTCCACAGGAT
    GCAGCTAGTTGTATTTCTATCATGGCTACAAATGGTGGAAAACCACAGGATTATGAAGGG
    CTTCATAAGTCTGCTAAAAAAGGCTTGCCAGTTGTGGCTATCAATACAACGGCAGGTACA
    TCAGCAGAAATTACCATTAACTATGTGATTACTGATGAAGAACGCAAGGTTAAGATGGTA
    ATGGTTGACAAGAATAGCCTTGCTCTTATCTCTGTTAATGACCCTGAACTCATGCTTTCC
    AAACCTAAAGGCCTGACTGCTGCTACTGGTATGGATGCTCTGACTCATGCTGTTGAAGCT
    TTGGTAACACCTGGTGCTTATGATGTAACCAAGAAACTGTCTATTGGTGCTATTGAGCTT
    ATCAAGGAATATCTTCCTCGTGCTGTAGAAAATGGACATGATATTGAAGCGCGTGAAGGT
    ATGGTCAATGCCATCTTCCTTGGTGGTATGAGCTTTAATAATGCTGGTCTTGGGTATGTT
    CACTCAATGGCTCACCAACTCGGTGCAGTATATAATTTGCCACATGGCGTGTGCTGTGCC
    ATGTTGCTACCAGTTATAGAACGTGAAAATGCTAAACGTGTACCAGAAGCTTTCCGCAAT
    GTTGCCAAAGCCTTGGGACTTCATGTAGAAGGTAAATCAGATCAAGAATGTGCCGATTAT
    GCGATTGCTGAGATTGAGAAGCTTTCTGAGACAGTAGGTATTCCTAAGAAACTGACTGAA
    CTTGGTATTGAAGAAAAAGATTTCGACTTTGAATACCTTTCTAAGAATGCCTTGATTGAT
    GCCTGCGCACCAGGAAATCCATTTATGCCAACCTTAGAAGAAACGATTGCCTTTTATAAA
    GAGTTATTTTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1152

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_2351 [new locus tag: SPH_RS11510 ]
  • symbol: SPH_2351
  • description: NAD-dependent methanol dehydrogenase (medh)
  • length: 383
  • theoretical pI: 4.70971
  • theoretical MW: 41212.2
  • GRAVY: 0.00522193

⊟Function[edit | edit source]

  • reaction:
    EC 1.1.1.244?  ExPASy
    Methanol dehydrogenase Methanol + NAD+ = formaldehyde + NADH
  • TIGRFAM:
    Metabolism Energy metabolism Sugars lactaldehyde reductase (TIGR02638; EC 1.1.1.77; HMM-score: 448.9)
    and 2 more
    NDMA-dependent methanol dehydrogenase (TIGR04266; EC 1.1.99.37; HMM-score: 200.1)
    phosphonate metabolism-associated iron-containing alcohol dehydrogenase (TIGR03405; HMM-score: 147.6)
  • TheSEED  :
    • Lactaldehyde dehydrogenase involved in fucose or rhamnose utilization (EC 1.2.1.22)
    Carbohydrates Monosaccharides L-fucose utilization  Lactaldehyde dehydrogenase involved in fucose or rhamnose utilization (EC 1.2.1.22)
  • PFAM:
    DHQS (CL0224) Fe-ADH; Iron-containing alcohol dehydrogenase (PF00465; HMM-score: 386.5)
    and 2 more
    Fe-ADH_2; Iron-containing alcohol dehydrogenase (PF13685; HMM-score: 70.3)
    Periplas_BP (CL0144) Peripla_BP_6; Periplasmic binding protein (PF13458; HMM-score: 17.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004588
    • TAT(Tat/SPI): 0.000215
    • LIPO(Sec/SPII): 0.000539
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MATFYVPAVNLIGKGVVNEVGPYIKELGYKKALLVTDKYIEGSDILPKTLKPLDTEGIEYVIFSDVEPNPTCKNVTDGVAALQEHGCDFIISLGGGSPQDAASCISIMATNGGKPQDYEGLHKSAKKGLPVVAINTTAGTSAEITINYVITDEERKVKMVMVDKNSLALISVNDPELMLSKPKGLTAATGMDALTHAVEALVTPGAYDVTKKLSIGAIELIKEYLPRAVENGHDIEAREGMVNAIFLGGMSFNNAGLGYVHSMAHQLGAVYNLPHGVCCAMLLPVIERENAKRVPEAFRNVAKALGLHVEGKSDQECADYAIAEIEKLSETVGIPKKLTELGIEEKDFDFEYLSKNALIDACAPGNPFMPTLEETIAFYKELF

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CcpA regulon
    CcpA(TF)important in Global catabolite repression; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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