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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_2382 [new locus tag: SPH_RS11655 ]
  • pan locus tag?: PNEUPAN003851000
  • symbol: SPH_2382
  • pan gene symbol?: —
  • synonym:
  • product: M protein trans-acting positive regulator (MGA)

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_2382 [new locus tag: SPH_RS11655 ]
  • symbol: SPH_2382
  • product: M protein trans-acting positive regulator (MGA)
  • replicon: chromosome
  • strand: -
  • coordinates: 2189715..2191124
  • length: 1410
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    ATGGAGAAAGCCGAGTGTGGTCAATTTTCAATCCTTTCCTTTCTATTACAAGAGTCTCAG
    ACGACCGTCAAGGCTGTAATGGAAGAAACAGGATTTTCAAAAGCAACCCTAACCAAATAT
    GTCACCCTGCTCAATGACAAGGCTTTGGATAGTGGCTTAGAACTGACTATTCACTCAGAA
    GATGAAAATCTGCGTCTGTCTATCGGTGCAGCTACCAAGGGGAGAGATATTCGGAGCTTG
    TTTTTGGAGAGTGCTGTTAAATACCAGATTTTGGTTTATCTTTTCTACCACCAACAGTTT
    TTAGCCCATCAGCTGGCTCAAGAATTGGTGATTAGCGAGGCTACGCTTGGTCGTCACTTG
    GCTGGTTTAAATCAGATTTTGTCAGAATTTGATTTATCCATCCAAAATGGACGTTGGCGA
    GGTCCAGAGCATCAGATTCGCTATTTCTATTTCTGTCTTTTCCGAAAGGTCTGGTCGAGT
    CAGGAATGGGAAGGTCACATGCAGAAACCAGAGAGAAAACAGGAGATTGCCAATTTAGAG
    GAAATCTGCGGTGCAAGTTTGTCTGTGGGGCAGAAATTGGACTTGGTTCTCTGGGCTCAC
    ATCAGTCAACAACGTCTTCGGGGCAATGCTTGTCAGTTTCAAGTCATAGAAGAGAAAATG
    CGAGGGTATTTTGACAATATCTTCTATCTTCGTTTGCTGAGAAAGGTTCCGTCCTTTTTT
    GCTGGGCAACATATTCCACTAGGAGTTGAGGATGGTGAGATGATGATATTCTTCTCTTTT
    CTCCTATCTCATCGCATTCTTCCTCTTCATACTATGGAGTATATTCTTGGTTTTGGAGGG
    CAGTTGGCAGATTTACTGACGCAATTGATTCAAGAAATGAAGAAGGAGGAACTATTGGGG
    GATTATACAGAGGACCATGTCACCTATGAACTCAGTCAGCTTTGTGCTCAAGTCTATCTC
    TATAAGGGCTATATTTTACAGGATCGCTACAAGTACCAGTTAGAGAATCGTCATCCATAT
    TTACTGATGGAACATGATTTTAAAGAGACAGCAGAGGAGATTTTTCATGCTCTACCTGCT
    TTTCAACAGGGGACAGATTTAGATAAGAAGATTCTCTGGGAATGGCTCCAGTTAATCGAA
    TATATGGCTGAAAACGGTGGCCAGCATATGCGGATTGGTCTGGATTTGACATCTGGTTTT
    CTTGTCTTTTCAAGGATGGCAGCCATTTTGAAACGGTATTTGGAATACAATCGTTTTATT
    ACCATTGAAGCTTATGACCCTAGTCGGCATTATGATTTGCTGGTTACCAATAACCCGATT
    CATAAGAAGGAACAGACACCAGTCTATTATTTAAAAAATGACTTGGATATGGAGGATTTG
    GCAGGGATTCGTCAGTTATTATTCACTTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1410

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_2382 [new locus tag: SPH_RS11655 ]
  • symbol: SPH_2382
  • description: M protein trans-acting positive regulator (MGA)
  • length: 469
  • theoretical pI: 5.82883
  • theoretical MW: 54824.6
  • GRAVY: -0.22516

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other iron-sulfur cluster biosynthesis transcriptional regulator SufR (TIGR02702; HMM-score: 19.3)
    Signal transduction Regulatory functions DNA interactions iron-sulfur cluster biosynthesis transcriptional regulator SufR (TIGR02702; HMM-score: 19.3)
  • TheSEED  :
    • Trans-acting positive regulator
  • PFAM:
    HTH (CL0123) Mga; Mga helix-turn-helix domain (PF05043; HMM-score: 97.8)
    and 10 more
    HTH_11; HTH domain (PF08279; HMM-score: 25.5)
    HTH_5; Bacterial regulatory protein, arsR family (PF01022; HMM-score: 20.4)
    MarR_2; MarR family (PF12802; HMM-score: 18.9)
    HTH_Mga; M protein trans-acting positive regulator (MGA) HTH domain (PF08280; HMM-score: 16.2)
    HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 15.7)
    HTH_DeoR; DeoR-like helix-turn-helix domain (PF08220; HMM-score: 15)
    MarR; MarR family (PF01047; HMM-score: 14.6)
    HTH_26; Cro/C1-type HTH DNA-binding domain (PF13443; HMM-score: 12.7)
    HTH_20; Helix-turn-helix domain (PF12840; HMM-score: 12.5)
    HTH_34; Winged helix DNA-binding domain (PF13601; HMM-score: 12)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.029731
    • TAT(Tat/SPI): 0.001203
    • LIPO(Sec/SPII): 0.001181
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MEKAECGQFSILSFLLQESQTTVKAVMEETGFSKATLTKYVTLLNDKALDSGLELTIHSEDENLRLSIGAATKGRDIRSLFLESAVKYQILVYLFYHQQFLAHQLAQELVISEATLGRHLAGLNQILSEFDLSIQNGRWRGPEHQIRYFYFCLFRKVWSSQEWEGHMQKPERKQEIANLEEICGASLSVGQKLDLVLWAHISQQRLRGNACQFQVIEEKMRGYFDNIFYLRLLRKVPSFFAGQHIPLGVEDGEMMIFFSFLLSHRILPLHTMEYILGFGGQLADLLTQLIQEMKKEELLGDYTEDHVTYELSQLCAQVYLYKGYILQDRYKYQLENRHPYLLMEHDFKETAEEIFHALPAFQQGTDLDKKILWEWLQLIEYMAENGGQHMRIGLDLTSGFLVFSRMAAILKRYLEYNRFITIEAYDPSRHYDLLVTNNPIHKKEQTPVYYLKNDLDMEDLAGIRQLLFT

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: CcpA regulon
    CcpA(TF)important in Global catabolite repression; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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