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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 10-MAR-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS01040 [old locus tag: SPH_0216 ]
  • pan locus tag?: PNEUPAN000492000
  • symbol: argH
  • pan gene symbol?: argH
  • synonym:
  • product: argininosuccinate lyase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS01040 [old locus tag: SPH_0216 ]
  • symbol: argH
  • product: argininosuccinate lyase
  • replicon: chromosome
  • strand: +
  • coordinates: 189689..191080
  • length: 1392
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    ATGGCTAAGAATACAAAATTATGGGGTGGTCGCTTTGAAGGTACTGTCGAAGACTGGGTA
    GAGCGCTTTGGTGCGAGTATATCTTTTGACCAGAAATTAGCTAAATTTGATGTGATTGGT
    TCTTTAGCCCACGTTCAGATGTTGGGTCAGACGGGCATTTTGAGTTTGGAGGAGTCAGAA
    AAGATTCAAGTAGGCTTGAAAGAGCTTTTAGAAGAGCTAGAGGCAGGTCAACTTGACTTT
    GATATCGCAAACGAAGATATTCATATGAATATGGAAGTGTTGCTGACAGAAAAAATTGGT
    CCCCTTGCAGGGAAGTTACATACGGCTCGTTCTCGAAATGACCAAGTTGCGACAGATATG
    CACTTGTATCTCAAGGAACAACTAGGCTATGTCCTAGATAAACTGGCTCATCTTAAGGGT
    GTTTTATTAGACTTGGCGGAAAATCATGTGGCGACGATCATGCCGGGCTATACCCATCTG
    CAACATGCCCAGCCTATTAGTTTTGCCTACCACCTGATGGCTTACTACAATATGTTTCAA
    AGAGACAGTGAACGTTTTGAATTTAACCAGAAGCATACAGACCTATGCCCTTTAGGTGCG
    GCAGCTTTGGCAGGAACGACTTTCCCCATTGATCGCCAATTATCTAGCGATTTGCTGGAG
    TTTAAGCAACCTTATACAAATTCTTTGGATGCTGTTAGTGACCGCGATTTTATCTTAGAA
    TTTCTATCAAATGCCAGCATACTCATGATGCATATGAGTCGTTTTTGCGAAGAAATGATT
    AATTGGTGTAGTTTTGAGTACCAATTCATTACCTTGTCAGATACGTTTACAATAGGTTCC
    TCTATTATGCCCCAAAAGAAAAATCCAGATATGGCTGAGTTGATTCGAGGAAAGACTGGC
    AGAGTTTATGGGCATTTGTTTGGACTGTTGACAGTCATGAAGTCCTTGCCTTTAGCTTAT
    AATAAGGATTTGCAAGAAGATAAGGAAGGAATGTTTGATACGGTCGAAACGATTTTAAAT
    TCCCTCGATGTGTTGGCAGGTATGTTATCTAGTTTGCAGGTAAACAAGGAAAAAATGCAA
    GAATCAACAGAGAAGGACTTTTCAAATGCAACTGAGTTGGCAGATTATTTGGCAGGGAAA
    GGCTTGCCATTTAGAGAAGCTCATGAGGTTGTGGGAAGATTAGTGCTAGACTCTATCAAG
    TCTGCTAAAAATCTTCAAGATTGGACTTTGGAGGAATTACAAACCTATCATTCTCTCATT
    ACCGAGGATATCTATGTCTACTTGCAACCTAAAACTGCTGTTCAAAGACGAAATTCCTTG
    GGAGGCACAGGGTTTGACCAAGTCGAATACCAGATTGCAGTCGCTAAGAAAGCGAATGAA
    GCTAAAAAGTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1392

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS01040 [old locus tag: SPH_0216 ]
  • symbol: ArgH
  • description: argininosuccinate lyase
  • length: 463
  • theoretical pI: 4.92488
  • theoretical MW: 52323.4
  • GRAVY: -0.243844

⊟Function[edit | edit source]

  • reaction:
    EC 4.3.2.1?  ExPASy
    Argininosuccinate lyase 2-(N(omega)-L-arginino)succinate = fumarate + L-arginine
  • TIGRFAM:
    Metabolism Amino acid biosynthesis Glutamate family argininosuccinate lyase (TIGR00838; EC 4.3.2.1; HMM-score: 626.9)
    and 4 more
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis adenylosuccinate lyase (TIGR00928; EC 4.3.2.2; HMM-score: 85.2)
    Metabolism Energy metabolism Other 3-carboxy-cis,cis-muconate cycloisomerase (TIGR02426; EC 5.5.1.2; HMM-score: 66.1)
    Metabolism Energy metabolism Amino acids and amines aspartate ammonia-lyase (TIGR00839; EC 4.3.1.1; HMM-score: 47.8)
    Metabolism Energy metabolism TCA cycle fumarate hydratase, class II (TIGR00979; EC 4.2.1.2; HMM-score: 36.7)
  • TheSEED: see SPH_0216
  • PFAM:
    no clan defined Lyase_1; Lyase (PF00206; HMM-score: 221.2)
    and 2 more
    ASL_C2; Argininosuccinate lyase C-terminal (PF14698; HMM-score: 82)
    TPR (CL0020) SPO22; Meiosis protein SPO22/ZIP4 like (PF08631; HMM-score: 16.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002392
    • TAT(Tat/SPI): 0.000423
    • LIPO(Sec/SPII): 0.000219
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MAKNTKLWGGRFEGTVEDWVERFGASISFDQKLAKFDVIGSLAHVQMLGQTGILSLEESEKIQVGLKELLEELEAGQLDFDIANEDIHMNMEVLLTEKIGPLAGKLHTARSRNDQVATDMHLYLKEQLGYVLDKLAHLKGVLLDLAENHVATIMPGYTHLQHAQPISFAYHLMAYYNMFQRDSERFEFNQKHTDLCPLGAAALAGTTFPIDRQLSSDLLEFKQPYTNSLDAVSDRDFILEFLSNASILMMHMSRFCEEMINWCSFEYQFITLSDTFTIGSSIMPQKKNPDMAELIRGKTGRVYGHLFGLLTVMKSLPLAYNKDLQEDKEGMFDTVETILNSLDVLAGMLSSLQVNKEKMQESTEKDFSNATELADYLAGKGLPFREAHEVVGRLVLDSIKSAKNLQDWTLEELQTYHSLITEDIYVYLQPKTAVQRRNSLGGTGFDQVEYQIAVAKKANEAKK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: AhrC*, ArgR1*, ArgR2* see SPH_0216

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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