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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS02280 [old locus tag: SPH_0469 ]
  • pan locus tag?: PNEUPAN001178000
  • symbol: rfbD
  • pan gene symbol?: cps2O
  • synonym:
  • product: dTDP-4-dehydrorhamnose reductase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS02280 [old locus tag: SPH_0469 ]
  • symbol: rfbD
  • product: dTDP-4-dehydrorhamnose reductase
  • replicon: chromosome
  • strand: +
  • coordinates: 418998..419849
  • length: 852
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGATTTTAATTACAGGGGCAAATGGCCAATTAGGAACGGAACTTCGCTATTTATTGGAT
    GAACGTAATGAAGAATACGTGGCAGTAGATGTGGCTGAGATGGACATTACCGATGCAGAA
    ATGGTTGAGAAAGTTTTTGAAGAGGTGAAACCGACTTTAGTCTACCACTGTGCAGCCTAC
    ACCGCTGTTGATGCAGCAGAGGATGAAGGAAGAGAGTTGGACTTCGCCATCAATGTGACG
    GGGACAAAAAATGTCGCAAAAGCATCTGAAAAGCATGGTGCAACTCTAGTTTATATTTCT
    ACGGACTATGTCTTTGATGGTAAGAAACCAGTTGGACAAGAGTGGGAAGTTGATGACCGA
    CCAGATCCACAGACAGAATATGGCCGTACTAAGCGTATGGGGGAAGAGTTAGTTGAGAAG
    CATGTGTCTAATTTCTATATTATCCGTACTGCCTGGGTATTTGGAAATTATGGCAAAAAC
    TTCGTTTTTACCATGCAAAATCTTGCGAAAACTCATAAGACTTTAACAGTTGTAAATGAC
    CAGTACGGTCGTCCGACTTGGACTCGTACCTTGGCTGAGTTCATGACCTACCTAGCTGAA
    AATCGTAAGGAATTTGGTTATTATCATTTGTCAAATGATGCGACAGAAGACACAACATGG
    TATGATTTTGCAGTTGAAATTTTGAAAGATACAGATGTCGAAGTCAAGCCAGTAGATTCC
    AGTCAATTTCCAGCCAAAGCTAAACGTCCGCTAAACTCAACGATGAGCCTGGCCAAAGCC
    AAAGCTACTGGATTTGTTATTCCAACTTGGCAAGATGCATTGCAAGAATTTTACAAACAA
    GAAGTGAGATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    852

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS02280 [old locus tag: SPH_0469 ]
  • symbol: RfbD
  • description: dTDP-4-dehydrorhamnose reductase
  • length: 283
  • theoretical pI: 4.59129
  • theoretical MW: 32331
  • GRAVY: -0.496113

⊟Function[edit | edit source]

  • reaction:
    EC 1.1.1.133?  ExPASy
    dTDP-4-dehydrorhamnose reductase dTDP-beta-L-rhamnose + NADP+ = dTDP-4-dehydro-beta-L-rhamnose + NADPH
  • TIGRFAM:
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides dTDP-4-dehydrorhamnose reductase (TIGR01214; EC 1.1.1.133; HMM-score: 281.2)
    and 10 more
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides dTDP-glucose 4,6-dehydratase (TIGR01181; EC 4.2.1.46; HMM-score: 44)
    Metabolism Energy metabolism Sugars UDP-glucose 4-epimerase GalE (TIGR01179; EC 5.1.3.2; HMM-score: 38)
    thioester reductase domain (TIGR01746; HMM-score: 36)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides CDP-glucose 4,6-dehydratase (TIGR02622; EC 4.2.1.45; HMM-score: 34)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides ADP-glyceromanno-heptose 6-epimerase (TIGR02197; EC 5.1.3.20; HMM-score: 23.7)
    NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family (TIGR04180; HMM-score: 23.3)
    hopanoid-associated sugar epimerase (TIGR03466; HMM-score: 22)
    Metabolism Energy metabolism Biosynthesis and degradation of polysaccharides 2-deoxy-D-gluconate 3-dehydrogenase (TIGR01832; EC 1.1.1.125; HMM-score: 14.8)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides GDP-mannose 4,6-dehydratase (TIGR01472; EC 4.2.1.47; HMM-score: 14.5)
    Metabolism Amino acid biosynthesis Glutamate family N-acetyl-gamma-glutamyl-phosphate reductase (TIGR01850; EC 1.2.1.38; HMM-score: 12.2)
  • TheSEED: see SPH_0469
  • PFAM:
    NADP_Rossmann (CL0063) RmlD_sub_bind; RmlD substrate binding domain (PF04321; HMM-score: 361.2)
    and 8 more
    Epimerase; NAD dependent epimerase/dehydratase family (PF01370; HMM-score: 92.3)
    3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family (PF01073; HMM-score: 52)
    GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase (PF16363; HMM-score: 51.2)
    Polysacc_synt_2; Polysaccharide biosynthesis protein (PF02719; HMM-score: 48.7)
    NAD_binding_4; Male sterility protein (PF07993; HMM-score: 43.6)
    KR; KR domain (PF08659; HMM-score: 15.3)
    Semialdhyde_dh; Semialdehyde dehydrogenase, NAD binding domain (PF01118; HMM-score: 14.4)
    adh_short_C2; Enoyl-(Acyl carrier protein) reductase (PF13561; HMM-score: 13.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9966
    • Cytoplasmic Membrane Score: 0.0009
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0023
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001954
    • TAT(Tat/SPI): 0.000208
    • LIPO(Sec/SPII): 0.000297
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MILITGANGQLGTELRYLLDERNEEYVAVDVAEMDITDAEMVEKVFEEVKPTLVYHCAAYTAVDAAEDEGRELDFAINVTGTKNVAKASEKHGATLVYISTDYVFDGKKPVGQEWEVDDRPDPQTEYGRTKRMGEELVEKHVSNFYIIRTAWVFGNYGKNFVFTMQNLAKTHKTLTVVNDQYGRPTWTRTLAEFMTYLAENRKEFGYYHLSNDATEDTTWYDFAVEILKDTDVEVKPVDSSQFPAKAKRPLNSTMSLAKAKATGFVIPTWQDALQEFYKQEVR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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