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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS02655 [old locus tag: SPH_0545 ]
  • pan locus tag?: PNEUPAN001284000
  • symbol: SPH_RS02655
  • pan gene symbol?: prfC
  • synonym:
  • product: peptide chain release factor 3

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS02655 [old locus tag: SPH_0545 ]
  • symbol: SPH_RS02655
  • product: peptide chain release factor 3
  • replicon: chromosome
  • strand: +
  • coordinates: 493410..494954
  • length: 1545
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    ATGAATATTCAAGAAGAAATTAAGAAACGTCGTACCTTTGCCATTATTTCCCACCCGGAC
    GCGGGGAAAACAACCATCACTGAGCAGTTACTCTACTTTGGGGGTGAGATTCGTGAGGCT
    GGTACGGTAAAAGGGAAGAAAACAGGGACTTTTGCTAAATCTGACTGGATGGATATCGAG
    AAGCAACGTGGGATTTCTGTTACTTCATCTGTTATGCAATTTGACTACGACGGCAAGCGC
    GTGAATATCTTAGACACGCCAGGGCACGAGGACTTCTCAGAAGATACCTATCGTACCTTG
    ATGGCGGTGGATGCTGCGGTCATGGTCGTGGACTCTGCCAAGGGGATCGAGGCTCAAACC
    AAGAAATTGTTTGAGGTTGTGAAACATCGTGGCATTCCAGTCTTTACCTTTATGAACAAG
    CTGGACCGTGACGGTCGTGAGCCTTTGGATCTGTTGCAAGAATTGGAAGAAATCTTGGGC
    ATTGCTAGCTACCCTATGAACTGGCCTATCGGGATGGGGAAAGCCTTTGAGGGCTTGTAT
    GACCTCTATAACCAACGTTTAGAGCTTTACAAAGGGGATGAGCGTTTTGCCAGTCTAGAA
    GACGGGGACAAACTCTTTGGTAGCAATCCTTTCTACGAGCAAGTCAAGGATGACATTGAG
    CTTTTAAATGAAGCCGGGAATGAGTTTTCAGAGGAAGCTATTTTGGCTGGAGAATTGACG
    CCTGTCTTTTTCGGTTCAGCCCTGACAAACTTTGGTGTGCAGACCTTCCTTGAAACCTTC
    CTCAAGTTTGCTCCAGAACCACATGGTCACAAGAAAACAGACGGTGAAATTGTGGATCCT
    TATGACAAGGATTTCTCAGGCTTTGTCTTTAAAATCCAAGCCAACATGGATCCTCGTCAC
    CGTGACCGTATTGCCTTTGTCCGTATCGTATCAGGCGAATTTGAGCGCGGCATGAGTGTC
    AATCTCCCTCGTACTGGTAAGGGGGCTAAACTATCTAATGTTACCCAGTTTATGGCGGAG
    AGTCGTGAGAATGTGACCAATGCCGTGGCAGGTGATATTATCGGGGTTTACGATACCGGT
    ACTTATCAGGTTGGGGATACCTTGACGGTTGGAAAAAACAAGTTTGAATTTGAACCACTG
    CCAACCTTTACTCCTGAAATTTTCATGAAAGTTTCTGCTAAGAATGTTATGAAGCAAAAA
    TCCTTCCACAAGGGGATTGAGCAATTGGTGCAAGAAGGAGCCGTTCAGCTTTATAAGAAT
    TACCAAACAAGTGAGTACATGCTAGGCGCTGTTGGTCAACTCCAGTTTGAAGTCTTTAAA
    CACCGTATGGAAGGCGAATACAATGCGGAAGTGGTCATGAGCCCAATGGGTAAAAAGACC
    GTTCGTTGGATCAAGCCTGAGGACTTGGATGAACGGATGTCGTCAAGTCGCAATATCTTA
    GCCAAAGACCGTTTTGACCAACCAGTCTTTCTCTTTGAAAATGACTTTGCCCTCCGCTGG
    TTTGCGGACAAGTATCCAGACGTAGAGTTAGAGGAGAAGATGTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1545

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS02655 [old locus tag: SPH_0545 ]
  • symbol: SPH_RS02655
  • description: peptide chain release factor 3
  • length: 514
  • theoretical pI: 4.83453
  • theoretical MW: 58488
  • GRAVY: -0.447276

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein synthesis Translation factors peptide chain release factor 3 (TIGR00503; HMM-score: 657.7)
    and 18 more
    Genetic information processing Protein synthesis Translation factors translation elongation factor G (TIGR00484; HMM-score: 232.5)
    Unknown function General elongation factor 4 (TIGR01393; EC 3.6.5.-; HMM-score: 127.3)
    Cellular processes Cellular processes Adaptations to atypical conditions GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 117.2)
    Genetic information processing Protein synthesis Translation factors GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 117.2)
    Signal transduction Regulatory functions Other GTP-binding protein TypA/BipA (TIGR01394; HMM-score: 117.2)
    Genetic information processing Protein synthesis Translation factors translation elongation factor aEF-2 (TIGR00490; HMM-score: 110.1)
    Unknown function General small GTP-binding protein domain (TIGR00231; HMM-score: 74.3)
    Genetic information processing Protein synthesis Translation factors translation elongation factor Tu (TIGR00485; HMM-score: 58.8)
    Genetic information processing Protein synthesis Translation factors selenocysteine-specific translation elongation factor (TIGR00475; HMM-score: 49.7)
    Genetic information processing Protein synthesis Translation factors translation elongation factor EF-1, subunit alpha (TIGR00483; HMM-score: 49.5)
    Genetic information processing Protein synthesis Translation factors translation initiation factor IF-2 (TIGR00487; HMM-score: 47.8)
    Metabolism Central intermediary metabolism Sulfur metabolism sulfate adenylyltransferase, large subunit (TIGR02034; EC 2.7.7.4; HMM-score: 35.7)
    Genetic information processing Protein synthesis Translation factors translation initiation factor aIF-2 (TIGR00491; HMM-score: 35.5)
    Genetic information processing Protein synthesis Other ribosome-associated GTPase EngA (TIGR03594; HMM-score: 27.3)
    Genetic information processing Protein fate Protein modification and repair [FeFe] hydrogenase H-cluster maturation GTPase HydF (TIGR03918; HMM-score: 21.6)
    translation initiation factor 2, gamma subunit (TIGR03680; HMM-score: 19.9)
    Metabolism Transport and binding proteins Cations and iron carrying compounds ferrous iron transport protein B (TIGR00437; HMM-score: 13)
    Genetic information processing Protein synthesis Other ribosome biogenesis GTP-binding protein YsxC (TIGR03598; HMM-score: 11.7)
  • TheSEED: see SPH_0545
  • PFAM:
    P-loop_NTPase (CL0023) GTP_EFTU; Elongation factor Tu GTP binding domain (PF00009; HMM-score: 171.3)
    EF-G_C (CL0437) RF3_C; Class II release factor RF3, C-terminal domain (PF16658; HMM-score: 146.6)
    and 6 more
    EFTPs (CL0575) GTP_EFTU_D2; Elongation factor Tu domain 2 (PF03144; HMM-score: 47.5)
    EF-G_C (CL0437) EFG_III; Elongation Factor G, domain III (PF14492; HMM-score: 31.2)
    P-loop_NTPase (CL0023) MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 29.1)
    SRPRB; Signal recognition particle receptor beta subunit (PF09439; HMM-score: 16.5)
    FeoB_N; Ferrous iron transport protein B (PF02421; HMM-score: 15.6)
    Roc; Ras of Complex, Roc, domain of DAPkinase (PF08477; HMM-score: 12.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.974
    • Cytoplasmic Membrane Score: 0.0007
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0253
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.011405
    • TAT(Tat/SPI): 0.002521
    • LIPO(Sec/SPII): 0.001918
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MNIQEEIKKRRTFAIISHPDAGKTTITEQLLYFGGEIREAGTVKGKKTGTFAKSDWMDIEKQRGISVTSSVMQFDYDGKRVNILDTPGHEDFSEDTYRTLMAVDAAVMVVDSAKGIEAQTKKLFEVVKHRGIPVFTFMNKLDRDGREPLDLLQELEEILGIASYPMNWPIGMGKAFEGLYDLYNQRLELYKGDERFASLEDGDKLFGSNPFYEQVKDDIELLNEAGNEFSEEAILAGELTPVFFGSALTNFGVQTFLETFLKFAPEPHGHKKTDGEIVDPYDKDFSGFVFKIQANMDPRHRDRIAFVRIVSGEFERGMSVNLPRTGKGAKLSNVTQFMAESRENVTNAVAGDIIGVYDTGTYQVGDTLTVGKNKFEFEPLPTFTPEIFMKVSAKNVMKQKSFHKGIEQLVQEGAVQLYKNYQTSEYMLGAVGQLQFEVFKHRMEGEYNAEVVMSPMGKKTVRWIKPEDLDERMSSSRNILAKDRFDQPVFLFENDFALRWFADKYPDVELEEKM

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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