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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS04500 [old locus tag: SPH_0930 ]
  • pan locus tag?: PNEUPAN001779000
  • symbol: SPH_RS04500
  • pan gene symbol?: flaR
  • synonym:
  • product: lipase family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS04500 [old locus tag: SPH_0930 ]
  • symbol: SPH_RS04500
  • product: lipase family protein
  • replicon: chromosome
  • strand: +
  • coordinates: 860649..861044
  • length: 396
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_010380 (860649..861044) NCBI
  • BioCyc: SPH_RS04500 BioCyc
  • MicrobesOnline: see SPH_0930
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    GTGCTAGATTCTAAGGAGGAATTGAAAGAGTCAGAAAATGATGCTCCAAAACTAGAAACT
    CCTCTTAGAGAGGAGCCAAGACTAGCTCCTCAAACGCTTCCGGAAGCAAGTGAAGTTCTT
    GAAAACAAAAGGGAAGAGTCAAAAGTAGAGATAACAGAGCCAGCTCAAGCGGATGATATC
    CGCAAGGTTGTTGGGGAATTAGCCAAGGATATAAGTATTACTAAGTTGTATATGACAGGT
    CATTCTCTTGGAGGCTACCTAGCTCAGATTGCAGCGGTTGAAGATTACCAAAAATATCCT
    GATTTTTATAACCATGTATTGAGGAAAGTGACAACTTTCAGTGCTCCTAAAGTCATTACT
    TCCAGAACTGTTTGGGATGCTAAGAATGGTTTCTGA
    60
    120
    180
    240
    300
    360
    396

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS04500 [old locus tag: SPH_0930 ]
  • symbol: SPH_RS04500
  • description: lipase family protein
  • length: 131
  • theoretical pI: 4.74328
  • theoretical MW: 14808.6
  • GRAVY: -0.646565

⊟Function[edit | edit source]

  • reaction:
    EC 3.1.1.-?  ExPASy
  • TIGRFAM:
    proline-specific peptidase (TIGR01250; HMM-score: 15.7)
    glutaredoxin (TIGR02180; HMM-score: 14.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (TIGR03695; EC 4.2.99.20; HMM-score: 13.9)
    and 1 more
    Metabolism Energy metabolism Other 3-oxoadipate enol-lactonase (TIGR02427; EC 3.1.1.24; HMM-score: 11.2)
  • TheSEED: see SPH_0930
  • PFAM:
    AB_hydrolase (CL0028) Lipase_3; Lipase (class 3) (PF01764; HMM-score: 31.2)
    and 12 more
    Hydrolase_4; Serine aminopeptidase, S33 (PF12146; HMM-score: 18.3)
    Abhydrolase_6; Alpha/beta hydrolase family (PF12697; HMM-score: 16.6)
    DUF915; Alpha/beta hydrolase of unknown function (DUF915) (PF06028; HMM-score: 16.1)
    PGAP1; PGAP1-like protein (PF07819; HMM-score: 14.6)
    Peptidase_S9; Prolyl oligopeptidase family (PF00326; HMM-score: 14.4)
    Mbeg1-like; Mbeg1-like (PF11187; HMM-score: 14.3)
    Abhydrolase_3; alpha/beta hydrolase fold (PF07859; HMM-score: 13.7)
    LIDHydrolase; Lipid-droplet associated hydrolase (PF10230; HMM-score: 13.6)
    BD-FAE; BD-FAE (PF20434; HMM-score: 13.5)
    Abhydrolase_1; alpha/beta hydrolase fold (PF00561; HMM-score: 13.1)
    DUF676; Putative serine esterase (DUF676) (PF05057; HMM-score: 12.8)
    Esterase; Putative esterase (PF00756; HMM-score: 12.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Extracellular
    • Cytoplasmic Score: 0.0004
    • Cytoplasmic Membrane Score: 0.0053
    • Cell wall & surface Score: 0.0006
    • Extracellular Score: 0.9936
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006876
    • TAT(Tat/SPI): 0.001212
    • LIPO(Sec/SPII): 0.001485
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MLDSKEELKESENDAPKLETPLREEPRLAPQTLPEASEVLENKREESKVEITEPAQADDIRKVVGELAKDISITKLYMTGHSLGGYLAQIAAVEDYQKYPDFYNHVLRKVTTFSAPKVITSRTVWDAKNGF

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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