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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 24-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS04955 [old locus tag: SPH_1026 ]
  • pan locus tag?: PNEUPAN001895000
  • symbol: SPH_RS04955
  • pan gene symbol?: cad
  • synonym:
  • product: aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS04955 [old locus tag: SPH_1026 ]
  • symbol: SPH_RS04955
  • product: aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme
  • replicon: chromosome
  • strand: +
  • coordinates: 946806..948281
  • length: 1476
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    TTGAAAGAGTTAGATCAAAACCAAGCCCCAATTTATGAGGCCTTGGTGAAGTTACGCAAG
    AAAAGGATTGTTCCCTTTGATGTTCCAGGTCACAAGCGTGGACGGGGAAATCCAGAACTT
    GTCGAACTCTTAGGAGAAAAATGTGTAGGCATTGATGTCAATTCGATGAAACCCTTGGAT
    AATTTAGGCCATCCTATTTCGATTATTCGTGATGCAGAGGAGCTGGCTGCAGATGCTTTT
    GGAGCTAGCCATGCCTTTCTAATGATTGGTGGAACAACTTCATCGGTGCAGACTATGATT
    CTGGCAACCTGCAAGGCAGGAGATAAGATTATTCTGCCACGAAATGTCCATAAATCTGCT
    ATCAATGCGTTGGTTCTATGTGGTGCCATTCCCATCTATATCGAGATGAGTGTAGATCCT
    AAGATTGGTATCGCTTTAGGTCTTGAAAATGACCGAGTAGCACAGGCCATAAAGGACCAT
    CCAGATGCTAAGGCTATCCTAATCAACAATCCTACTTACTACGGCATCTGTTCAGACCTA
    AAGGGGTTGACAGAAATGGCTCATGAAGCTGGCATGATGGTTTTAGTAGATGAAGCCCAT
    GGAGCGCATTTGCATTTCACTGGTAAACTTCCAATTTCTGCTATGGATGCAGGAGCTGAT
    ATGGCAGCAGTTTCCATGCATAAGTCTGGTGGGAGTTTGACACAAAGTTCGCTTCTTTTA
    ATCGGGGAGCAGATGAATCCCGAGTACGTTCGTCAGATTATAAACCTGACACAGTCTACA
    TCTGCCTCTTACTTATTGATGGCTAGTTTGGATATTTCACGTCGCAACTTGGCCCTTCGT
    GGTAAAGAGTCGTTTGAGGAAGTCATTGAGCTATCCGAGTACGCTCGTCATGAAATCAAT
    GCCATTGGCGGTTACTATGCTTACTCAAAAGAGTTAATAGATGGTGTGTCGGTCTGTGAT
    TTTGATGTAACCAAGTTGTCAGTTTACACTCAGGGAATAGGCTTAACAGGTATCGAGGTT
    TATGACCTCTTGCGAGACGAATACGACATTCAGATCGAGTTTGGTGATATCGGCAATATC
    TTGGCCTATATTTCCATCGGCGACCGCATCCAAGACATCGAGCGCTTGGTTGGTGCTCTG
    GCTGATATTAAGAGACTCTATTCACGAGATGGGAAGGACTTAATAGCTGGAGAATATATT
    CAGCCCGAGTTGGTGCTGTCTCCACAAGAAGCCTTCTATTCAGAGAGAAAAAGTTTGACC
    TTAGATGAGTCTGTTGGACAGGTCTGTGGAGAATTTGTCATGTGCTATCCTCCAGGGATT
    CCTATCTTGGCTCCTGGTGAACGCATTACACGAGAAATTGTAGACTATATCCAATTCGCC
    AAGGAACGTGGTTGCTCCCTCCAAGGGACGGAAGATCCAGAGGTCAATCATATCAACGTT
    ATTAAGAGAAAGACAAACTATAAGAAAAGTCAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1476

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS04955 [old locus tag: SPH_1026 ]
  • symbol: SPH_RS04955
  • description: aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme
  • length: 491
  • theoretical pI: 4.99813
  • theoretical MW: 53885.6
  • GRAVY: -0.0672098

⊟Function[edit | edit source]

  • reaction:
    EC 4.1.1.-?  ExPASy
  • TIGRFAM:
    putative ornithine decarboxylase (TIGR04318; EC 4.1.1.-; HMM-score: 62.4)
    ornithine decarboxylase SpeF (TIGR04301; EC 4.1.1.17; HMM-score: 61.6)
    and 20 more
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides TDP-4-keto-6-deoxy-D-glucose transaminase (TIGR02379; HMM-score: 34.5)
    O-phospho-L-seryl-tRNA:Cys-tRNA synthase (TIGR02539; EC 2.5.1.73; HMM-score: 31.3)
    UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine transaminase (TIGR03588; EC 2.6.1.92; HMM-score: 28.6)
    Metabolism Amino acid biosynthesis Aspartate family O-succinylhomoserine sulfhydrylase (TIGR01325; EC 4.2.99.-; HMM-score: 26.2)
    dTDP-4-dehydro-6-deoxyglucose aminotransferase (TIGR04427; EC 2.-.-.-; HMM-score: 24.3)
    Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01977; HMM-score: 23.4)
    Unknown function Enzymes of unknown specificity pyridoxal phosphate enzyme, MJ0158 family (TIGR03576; HMM-score: 20.9)
    aminotransferase, LLPSF_NHT_00031 family (TIGR04181; HMM-score: 19.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other tyrosine decarboxylase MnfA (TIGR03812; EC 4.1.1.25; HMM-score: 18.6)
    tyrosine/nicotianamine family aminotransferase (TIGR01265; HMM-score: 17.4)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other cysteine desulfurase, SufS family (TIGR01979; HMM-score: 17.1)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin 8-amino-7-oxononanoate synthase (TIGR00858; EC 2.3.1.47; HMM-score: 16.9)
    Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01976; HMM-score: 16.8)
    cystathionine beta-lyase (TIGR01329; EC 4.4.1.8; HMM-score: 14.8)
    Metabolism Energy metabolism Amino acids and amines tyrosine aminotransferase (TIGR01264; EC 2.6.1.5; HMM-score: 14.1)
    cysteine desulfurase, NifS family (TIGR03403; EC 2.8.1.7; HMM-score: 12)
    2-aminoethylphosphonate aminotransferase (TIGR03301; EC 2.6.1.-; HMM-score: 11.8)
    Genetic information processing Protein synthesis tRNA and rRNA base modification cysteine desulfurase IscS (TIGR02006; EC 2.8.1.7; HMM-score: 11.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other cysteine desulfurase IscS (TIGR02006; EC 2.8.1.7; HMM-score: 11.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other cysteine desulfurase, catalytic subunit CsdA (TIGR03392; EC 2.8.1.7; HMM-score: 11.4)
  • TheSEED: see SPH_1026
  • PFAM:
    PLP_aminotran (CL0061) OKR_DC_1; Orn/Lys/Arg decarboxylase, major domain (PF01276; HMM-score: 231.4)
    and 8 more
    Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 42.9)
    Aminotran_5; Aminotransferase class-V (PF00266; HMM-score: 41.9)
    no clan defined OKR_DC_1_C; Orn/Lys/Arg decarboxylase, C-terminal domain (PF03711; HMM-score: 41.6)
    PLP_aminotran (CL0061) DegT_DnrJ_EryC1; DegT/DnrJ/EryC1/StrS aminotransferase family (PF01041; HMM-score: 40.2)
    Cys_Met_Meta_PP; Cys/Met metabolism PLP-dependent enzyme (PF01053; HMM-score: 21.9)
    Beta_elim_lyase; Beta-eliminating lyase (PF01212; HMM-score: 18.5)
    no clan defined PrmC_N; PrmC N-terminal domain (PF17827; HMM-score: 13.6)
    PLP_aminotran (CL0061) GDC-P; Glycine cleavage system P-protein (PF02347; HMM-score: 11.4)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.97
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9764
    • Cytoplasmic Membrane Score: 0.0073
    • Cell wall & surface Score: 0.0002
    • Extracellular Score: 0.0161
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006633
    • TAT(Tat/SPI): 0.00043
    • LIPO(Sec/SPII): 0.000678
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKELDQNQAPIYEALVKLRKKRIVPFDVPGHKRGRGNPELVELLGEKCVGIDVNSMKPLDNLGHPISIIRDAEELAADAFGASHAFLMIGGTTSSVQTMILATCKAGDKIILPRNVHKSAINALVLCGAIPIYIEMSVDPKIGIALGLENDRVAQAIKDHPDAKAILINNPTYYGICSDLKGLTEMAHEAGMMVLVDEAHGAHLHFTGKLPISAMDAGADMAAVSMHKSGGSLTQSSLLLIGEQMNPEYVRQIINLTQSTSASYLLMASLDISRRNLALRGKESFEEVIELSEYARHEINAIGGYYAYSKELIDGVSVCDFDVTKLSVYTQGIGLTGIEVYDLLRDEYDIQIEFGDIGNILAYISIGDRIQDIERLVGALADIKRLYSRDGKDLIAGEYIQPELVLSPQEAFYSERKSLTLDESVGQVCGEFVMCYPPGIPILAPGERITREIVDYIQFAKERGCSLQGTEDPEVNHINVIKRKTNYKKSQ

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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