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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 10-MAR-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS05350 [old locus tag: SPH_1104 ]
  • pan locus tag?: PNEUPAN002032000
  • symbol: phtD
  • pan gene symbol?: phtD
  • synonym: phtB
  • product: pneumococcal histidine triad protein PhtD

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS05350 [old locus tag: SPH_1104 ]
  • symbol: phtD
  • product: pneumococcal histidine triad protein PhtD
  • replicon: chromosome
  • strand: +
  • coordinates: 1015515..1018064
  • length: 2550
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_010380 (1015515..1018064) NCBI
  • BioCyc: SPH_RS05350 BioCyc
  • MicrobesOnline: see SPH_1104
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    ATGAAAATCAATAAAAAATATCTAGCAGGTTCAGTGGCAGTCCTTGCCCTAAGTGTTTGT
    TCCTATGAACTTGGTCGTCACCAAGCTGGTCAGGTTAAGAAAGAGTCTAATCGAGTTTCT
    TATATAGATGGTGATCAGGCTGGTCAAAAGGCAGAAAATTTGACACCAGATGAAGTCAGT
    AAGAGAGAGGGGATCAACGCCGAACAAATCGTCATCAAGATTACGGATCAAGGTTATGTG
    ACCTCTCATGGAGACCATTATCATTACTATAATGGCAAGGTCCCTTATGATGCCATCATC
    AGTGAAGAGCTCCTCATGAAAGATCCGAATTATCAGTTGAAGGATTCAGACATTGTCAAT
    GAAATCAAGGGTGGTTATGTCATTAAGGTAAACGGTAAATACTATGTTTACCTTAAGGAT
    GCAGCTCATGCGGATAATATTCGGACAAAAGAAGAGATTAAACGTCAGAAGCAGGAACAC
    AGTCATAATCACGGGGGTGGTTCTAACGATCAAGCAGTAGTTGCAGCCAGAGCCCAAGGA
    CGCTATACAACGGATGATGGTTATATCTTCAATGCATCTGATATCATCGAAGATACGGGC
    GATGCCTATATCGTTCCTCATGGCAATCACTTCCACTATATTCCTAAGAGTGATTTATCT
    GCCAGTGAATTAGCTGCTGCCCAAGCCTATTGGAATGGGAAGCAGGGATCTCGTCCTTCT
    TCAAGTTCTAGTCATAATGCAAATCCAGCTCAACCAAGATTGTCAGAGAACCACAATCTG
    ACTGTCACTCCAACTTATCATCAAAATCAAGGGGAAAACATTTCAAGCCTTTTACGTGAA
    TTGTATGCTAAACCCTTATCAGAACGCCATGTGGAATCGGATGGCCTTATTTTCGACCCA
    GCGCAAATCACAAGTCGAACCGCCAGAGGTGTAGCTGTCCCTCATGGTAACCATTACCAC
    TTTATCCCTTATGAACAAATGTCTGAATTGGAAGAACGAATTGCTCGTATTATTCCCCTT
    CGTTATCGTTCAAACCATTGGGTACCAGATTCAAGACCAGAACAACCCAGTCCACAACCG
    ACTCCGGAACCTAGTCCAAGTCCGCAACCTGCACCAAATCCTCAACCAGCTCCAAGCAAT
    CCAATTGATGAGAAATTGGTCAAAGAAGCTGTTCGAAAAGTAGGCGATGGTTATGTCTTT
    GAGGAGAATGGAGTTTCTCGTTATATCCCAGCCAAGGATCTTTCAGCAGAAACAGCAGCA
    GGCATTGATAGCAAACTGGCCAAGCAGGAAAGTTTATCTCATAAGCTAGGAGCTAAGAAA
    ACTGACCTCCCATCTAGTGATAGAGAATTTTACAATAAGGCTTATGACTTACTAGCAAGA
    ATTCACCAAGATTTACTTGATAATAAAGGTCGACAAGTTGATTTTGAGGCTTTGGATAAC
    CTGTTGGAACGACTCAAGGATGTCTCAAGTGATAAAGTCAAGTTAGTGGATGATATTCTT
    GCCTTCTTAGCTCCGATTCGTCATCCAGAACGTTTAGGAAAACCAAATTCGCAAATTACC
    TACACTGATGATGAGATTCAAGTAGCCAAGTTGGCAGGCAAGTACACAACAGAAGACGGT
    TATATCTTTGATCCTCGTGATATAACCAGTGATGAGGGGGATGCCTATGTAACTCCACAT
    ATGACCCATAGCCACTGGATTAAAAAAGATAGTTTGTCTGAAGCTGAGAGAGCGGCAGCC
    CAGGCTTATGCTAAAGAGAAAGGTTTGACCCCTCCTTCGACAGACCATCAGGATTCAGGA
    AATACTGAGGCAAAAGGAGCAGAAGCTATCTACAACCGCGTGAAAGCAGCTAAGAAGGTG
    CCACTTGATCGTATGCCTTACAATCTTCAATATACTGTAGAAGTCAAAAACGGTAGTTTA
    ATCATACCTCATTATGACCATTACCATAACATCAAATTTGAGTGGTTTGACGAAGGCCTT
    TATGAGGCACCTAAGGGGTATACTCTTGAGGATCTTTTGGCGACTGTCAAGTACTATGTC
    GAACATCCAAACGAACGTCCGCATTCAGATAATGGTTTTGGTAACGCTAGCGACCATGTT
    CAAAGAAACAAAAATGGTCAAGCTGATACCAATCAAACGGAGAAACCTCAGACAGAAAAA
    CCTGAGGAAGATAAGGAACATGATGAAGTAAGTGAGCCAACTCACCCTGAATCTGATGAA
    AAAGAGAATCACGCTGGTTTAAATCCTTCAGCAGATAATCTTTATAAACCAAGCACTGAT
    ACGGAAGAGACAGAGGAAGAAGCTGAAGATACTACAGATGAGGCTGAAATTCCTCAAGTA
    GAGCATTCTGTTATTAACGCTAAGATAGCAGAGGCGGAGGCCTTGCTAGAAAAAGTAACA
    GATTCTAGTATTAGACAAAATGCTATGGAGACATTGACTGGTCTAAAAAGTAGTCTTCTT
    CTCGGAACGAAAGATAATAATACTATTTCAGCAGAAGTAGATAGTCTCTTGGCTTTGTTA
    AAAGAAAGTCAACCGGCTCCTATACAGTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2550

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS05350 [old locus tag: SPH_1104 ]
  • symbol: PhtD
  • description: pneumococcal histidine triad protein PhtD
  • length: 849
  • theoretical pI: 5.14904
  • theoretical MW: 94741.6
  • GRAVY: -0.851355

⊟Function[edit | edit source]

  • TIGRFAM:
    Cellular processes Cellular processes Pathogenesis streptococcal histidine triad protein (TIGR01363; HMM-score: 700.4)
    and 1 more
    heme uptake protein IsdC (TIGR03656; HMM-score: 14.3)
  • TheSEED: see SPH_1104
  • PFAM:
    no clan defined Strep_his_triad; Streptococcal histidine triad protein (PF04270; HMM-score: 254.3)
    and 2 more
    PHtD_u1; Unstructured region on Pneumococcal histidine triad protein (PF16645; HMM-score: 73.7)
    MID_MedPIWI; MID domain of medPIWI (PF18296; HMM-score: 8.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: Signal peptide LIPO(Sec/SPII) length 19 aa
    • SP(Sec/SPI): 0.077151
    • TAT(Tat/SPI): 0.000335
    • LIPO(Sec/SPII): 0.913577
    • Cleavage Site: CS pos: 19-20. LSV-CS. Pr: 0.9048
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKINKKYLAGSVAVLALSVCSYELGRHQAGQVKKESNRVSYIDGDQAGQKAENLTPDEVSKREGINAEQIVIKITDQGYVTSHGDHYHYYNGKVPYDAIISEELLMKDPNYQLKDSDIVNEIKGGYVIKVNGKYYVYLKDAAHADNIRTKEEIKRQKQEHSHNHGGGSNDQAVVAARAQGRYTTDDGYIFNASDIIEDTGDAYIVPHGNHFHYIPKSDLSASELAAAQAYWNGKQGSRPSSSSSHNANPAQPRLSENHNLTVTPTYHQNQGENISSLLRELYAKPLSERHVESDGLIFDPAQITSRTARGVAVPHGNHYHFIPYEQMSELEERIARIIPLRYRSNHWVPDSRPEQPSPQPTPEPSPSPQPAPNPQPAPSNPIDEKLVKEAVRKVGDGYVFEENGVSRYIPAKDLSAETAAGIDSKLAKQESLSHKLGAKKTDLPSSDREFYNKAYDLLARIHQDLLDNKGRQVDFEALDNLLERLKDVSSDKVKLVDDILAFLAPIRHPERLGKPNSQITYTDDEIQVAKLAGKYTTEDGYIFDPRDITSDEGDAYVTPHMTHSHWIKKDSLSEAERAAAQAYAKEKGLTPPSTDHQDSGNTEAKGAEAIYNRVKAAKKVPLDRMPYNLQYTVEVKNGSLIIPHYDHYHNIKFEWFDEGLYEAPKGYTLEDLLATVKYYVEHPNERPHSDNGFGNASDHVQRNKNGQADTNQTEKPQTEKPEEDKEHDEVSEPTHPESDEKENHAGLNPSADNLYKPSTDTEETEEEAEDTTDEAEIPQVEHSVINAKIAEAEALLEKVTDSSIRQNAMETLTGLKSSLLLGTKDNNTISAEVDSLLALLKESQPAPIQ

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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