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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 24-APR-2025
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae Hungary19A-6
- locus tag: SPH_RS05440 [old locus tag: SPH_1123 ]
- pan locus tag?: PNEUPAN002043000
- symbol: prfA
- pan gene symbol?: prfA
- synonym:
- product: peptide chain release factor 1
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SPH_RS05440 [old locus tag: SPH_1123 ]
- symbol: prfA
- product: peptide chain release factor 1
- replicon: chromosome
- strand: +
- coordinates: 1033629..1034708
- length: 1080
- essential: unknown other strains
⊟Accession numbers[edit | edit source]
- Location: NC_010380 (1033629..1034708) NCBI
- BioCyc: SPH_RS05440 BioCyc
- MicrobesOnline: see SPH_1123
- PneumoBrowse for strain D39V: SPV_0906 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
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1021ATGAACATCTATGATCAACTACAAGCTGTAGAAGACCGTTATGAAGAACTAGGAGAATTG
CTGAGTGACCCTGATGTCGTTTCAGACACCAGGCGTTTTATGGAGCTTTCAAAAGAAGAA
GCTTCCAATCGTGACACCGTAATAGCCTACCGTGAGTATAAACAAGTCCTTCAAAATATC
GTCGATGCCGAAGAGATGATTAAGGAATCAGGCGGAGATGCGGACTTGGAAGAAATGGCC
AAGCAAGAACTCAAAGATGCCAAGGCTGAAAAAGAAGAATATGAAGAAAAACTGAAAATT
TTGCTCCTTCCAAAGGATCCAAACGATGACAAGAATATCATCCTTGAAATCCGTGGAGCA
GCTGGTGGAGACGAAGCGGCACTTTTCGCTGGAGATTTGCTAACTATGTACCAAAAGTAT
GCGGAAGCCCAAGGTTGGCGCTTTGAAGTCATGGAAGCCTCTATGAATGGTGTCGGTGGT
TTTAAAGAAGTGGTTGCTATGGTTTCAGGTCAGTCTGTATACTCTAAGCTTAAGTATGAA
TCAGGTGCCCACCGTGTGCAACGTGTTCCTGTGACAGAAAGCCAAGGCCGTGTTCATACT
TCGACAGCGACAGTTCTTGTTATGCCAGAAGTTGAAGAGGTTGAATACGACATTGATCCA
AAAGACCTTCGTGTCGACATCTATCACGCCTCTGGTGCTGGTGGACAGAACGTCAATAAG
GTTGCGACTGCCGTTCGTATTGTTCACTTGCCAACCAATATCAAGGTTGAGATGCAGGAA
GAACGTACCCAGCAGAAGAACCGTGAGAAGGCTATGAAGATTATCCGTGCACGCGTCGCT
GACCACTTTGCTCAGATTGCTCAGGATGAACAAGACGCTGAGCGTAAGTCGACAATCGGT
ACTGGTGACCGTTCAGAACGGATCCGAACTTATAACTTCCCACAAAACCGTGTCACAGAC
CACCGTATCGGCTTGACCCTCCAAAAACTAGATACGATTTTGTCTGGTAAATTGGACGAA
GTTATGGATGCCTTGGTGCTTTATGACCAAACACAAAAACTAGAAGAATTAAACAAATAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPH_RS05440 [old locus tag: SPH_1123 ]
- symbol: PrfA
- description: peptide chain release factor 1
- length: 359
- theoretical pI: 4.58226
- theoretical MW: 40689.5
- GRAVY: -0.63649
⊟Function[edit | edit source]
- TIGRFAM: Protein synthesis Translation factors peptide chain release factor 1 (TIGR00019; HMM-score: 525.1)and 2 moreProtein synthesis Translation factors peptide chain release factor 2 (TIGR00020; HMM-score: 242.3)Protein synthesis Translation factors putative peptide chain release factor H (TIGR03072; HMM-score: 76.1)
- TheSEED: see SPH_1123
- PFAM: no clan defined PCRF; PCRF domain (PF03462; HMM-score: 234.2)and 3 moreRF (CL0337) RF-1; RF-1 domain (PF00472; HMM-score: 129)no clan defined ABC_tran_CTD; ABC transporter C-terminal domain (PF16326; HMM-score: 15)Occludin_ELL; Occludin homology domain (PF07303; HMM-score: 8.2)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9956
- Cytoplasmic Membrane Score: 0.0001
- Cell wall & surface Score: 0
- Extracellular Score: 0.0042
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.002507
- TAT(Tat/SPI): 0.00082
- LIPO(Sec/SPII): 0.000354
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MNIYDQLQAVEDRYEELGELLSDPDVVSDTRRFMELSKEEASNRDTVIAYREYKQVLQNIVDAEEMIKESGGDADLEEMAKQELKDAKAEKEEYEEKLKILLLPKDPNDDKNIILEIRGAAGGDEAALFAGDLLTMYQKYAEAQGWRFEVMEASMNGVGGFKEVVAMVSGQSVYSKLKYESGAHRVQRVPVTESQGRVHTSTATVLVMPEVEEVEYDIDPKDLRVDIYHASGAGGQNVNKVATAVRIVHLPTNIKVEMQEERTQQKNREKAMKIIRARVADHFAQIAQDEQDAERKSTIGTGDRSERIRTYNFPQNRVTDHRIGLTLQKLDTILSGKLDEVMDALVLYDQTQKLEELNK
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: SPH_RS05430 > SPH_RS05435 > prfA > prmC > SPH_RS05450 > SPH_RS05455 > glyA > SPH_RS05465 > pmp23 > SPH_RS05475 > rlmD
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription[edit | edit source]
- transcription start site:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0906 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]