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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 10-MAR-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS05685 [old locus tag: SPH_1173 ]
  • pan locus tag?: PNEUPAN002228000
  • symbol: SPH_RS05685
  • pan gene symbol?: murA-1
  • synonym:
  • product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS05685 [old locus tag: SPH_1173 ]
  • symbol: SPH_RS05685
  • product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase
  • replicon: chromosome
  • strand: +
  • coordinates: 1077173..1078432
  • length: 1260
  • essential: unknown other strains

⊟Accession numbers[edit | edit source]

  • Location: NC_010380 (1077173..1078432) NCBI
  • BioCyc: SPH_RS05685 BioCyc
  • MicrobesOnline: see SPH_1173
  • PneumoBrowse for strain D39V: SPV_0967 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    ATGAGAAAAATTGTTATCAATGGTGGATTACCACTGCAAGGTGAAATCACTATTAGTGGT
    GCTAAAAATAGTGTCGTTGCCTTAATTCCAGCTATTATCTTGGCTGATGATGTGGTGACT
    TTGGATTGCGTTCCAGATATTTCGGATGTAGCCAGTCTTGTCGAAATCATGGAATTGATG
    GGAGCTACTGTTAAGCGTTATGACGATGTATTGGAGATTGACCCAAGAGGTGTTCAAAAT
    ATTCCAATGCCTTATGGTAAAATTAACAGTCTTCGTGCATCTTACTATTTTTATGGGAGC
    CTCTTAGGCCGTTTTGGTGAAGCGACAGTTGGTCTACCGGGAGGATGTGATCTTGGTCCT
    CGTCCGATTGACTTACACCTTAAGGCGTTTGAAGCTATGGGTGCCACTGCTAGCTACGAG
    GGAGATAACATGAAGTTATCTGCTAAAGATACAGGACTTCATGGTGCAAGTATTTACATG
    GATACGGTTAGTGTGGGAGCAACGATTAATACGATGATTGCTGCGGTTAAAGCAAATGGT
    CGTACTATTATTGAAAATGCAGCCCGTGAACCTGAGATTATTGATGTAGCTACTCTCTTG
    AATAATATGGGTGCCCATATCCGTGGGGCAGGAACTAATATCATCATTATTGATGGTGTT
    GAAAGATTACATGGGACACGTCATCAGGTGATTCCAGACCGCATTGAAGCTGGAACATAT
    ATATCTTTAGCTGCTGCAGTTGGTAAAGGAATTCGTATAAATAATGTTCTTTACGAACAC
    CTGGAAGGGTTTATTGCTAAGTTGGAAGAAATGGGAGTGAGAATGACTGTATCTGAGGAC
    AGCATTTTTGTCGAGGAACAGTCTAATTTGAAAGCAATCAATATTAAGACAGCTCCTTAC
    CCAGGCTTTGCAACTGATTTGCAACAACCGCTTACCCCTCTTTTACTAAGAGCGAATGGT
    CGTGGTACAATTGTCGATACGATTTACGAAAAACGTGTAAATCATGTTTTTGAACTAGCA
    AAGATGGATGCGGATATTTCGACAACAAATGGTCATATTTTGTACACGGGTGGACGTGAT
    TTACGTGGGACCAGTGTTAAAGCGACCGACTTAAGAGCTGGGGCTGCACTAGTCATTGCT
    GGGCTTATGGCTGAAGGTAAAACTGAAATTACCAATATCGAGTTTATCTTACGTGGTTAT
    TCTGATATTATCGAAAAATTACGTAATTTAGGAGCGGATATTAGACTTGTTGAGGATTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_RS05685 [old locus tag: SPH_1173 ]
  • symbol: SPH_RS05685
  • description: UDP-N-acetylglucosamine 1-carboxyvinyltransferase
  • length: 419
  • theoretical pI: 5.06037
  • theoretical MW: 45054.6
  • GRAVY: 0.102148

⊟Function[edit | edit source]

  • reaction:
    EC 2.5.1.7?  ExPASy
    UDP-N-acetylglucosamine 1-carboxyvinyltransferase Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine
  • TIGRFAM:
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan UDP-N-acetylglucosamine 1-carboxyvinyltransferase (TIGR01072; EC 2.5.1.7; HMM-score: 497.6)
    and 1 more
    Metabolism Amino acid biosynthesis Aromatic amino acid family 3-phosphoshikimate 1-carboxyvinyltransferase (TIGR01356; EC 2.5.1.19; HMM-score: 76.5)
  • TheSEED: see SPH_1173
  • PFAM:
    EPT_RTPC (CL0290) EPSP_synthase; EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) (PF00275; HMM-score: 287.7)
    and 1 more
    NADP_Rossmann (CL0063) ADH_zinc_N; Zinc-binding dehydrogenase (PF00107; HMM-score: 17)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.075347
    • TAT(Tat/SPI): 0.000914
    • LIPO(Sec/SPII): 0.005153
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MRKIVINGGLPLQGEITISGAKNSVVALIPAIILADDVVTLDCVPDISDVASLVEIMELMGATVKRYDDVLEIDPRGVQNIPMPYGKINSLRASYYFYGSLLGRFGEATVGLPGGCDLGPRPIDLHLKAFEAMGATASYEGDNMKLSAKDTGLHGASIYMDTVSVGATINTMIAAVKANGRTIIENAAREPEIIDVATLLNNMGAHIRGAGTNIIIIDGVERLHGTRHQVIPDRIEAGTYISLAAAVGKGIRINNVLYEHLEGFIAKLEEMGVRMTVSEDSIFVEEQSNLKAINIKTAPYPGFATDLQQPLTPLLLRANGRGTIVDTIYEKRVNHVFELAKMDADISTTNGHILYTGGRDLRGTSVKATDLRAGAALVIAGLMAEGKTEITNIEFILRGYSDIIEKLRNLGADIRLVED

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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